DE60141994D1 - 13-substituierte Methacyclinverbindungen - Google Patents

13-substituierte Methacyclinverbindungen

Info

Publication number
DE60141994D1
DE60141994D1 DE60141994T DE60141994T DE60141994D1 DE 60141994 D1 DE60141994 D1 DE 60141994D1 DE 60141994 T DE60141994 T DE 60141994T DE 60141994 T DE60141994 T DE 60141994T DE 60141994 D1 DE60141994 D1 DE 60141994D1
Authority
DE
Germany
Prior art keywords
compounds
substituted
methacyclin
substituted methacycline
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141994T
Other languages
English (en)
Inventor
Mark L Nelson
Laura Roslindale Mcintyre
Glen Rennie
Beena Bhatia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Tufts University
Original Assignee
Paratek Pharmaceuticals Inc
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc, Tufts University filed Critical Paratek Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60141994D1 publication Critical patent/DE60141994D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
DE60141994T 2000-07-07 2001-06-29 13-substituierte Methacyclinverbindungen Expired - Lifetime DE60141994D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21658000P 2000-07-07 2000-07-07

Publications (1)

Publication Number Publication Date
DE60141994D1 true DE60141994D1 (de) 2010-06-10

Family

ID=22807633

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60141994T Expired - Lifetime DE60141994D1 (de) 2000-07-07 2001-06-29 13-substituierte Methacyclinverbindungen

Country Status (16)

Country Link
EP (3) EP1661883B1 (de)
JP (1) JP2004502751A (de)
KR (1) KR20030017609A (de)
CN (1) CN1452611A (de)
AT (2) ATE465989T1 (de)
AU (1) AU2001271616A1 (de)
BR (1) BR0112268A (de)
CA (1) CA2415172A1 (de)
CZ (1) CZ2003332A3 (de)
DE (1) DE60141994D1 (de)
EA (1) EA200300136A1 (de)
HR (1) HRP20030092A2 (de)
HU (1) HUP0301429A2 (de)
IL (1) IL153674A0 (de)
MX (1) MXPA03000036A (de)
WO (1) WO2002004405A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332904A3 (de) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivate von Tetracyclin-Verbindungen
EP2301916A3 (de) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-Aminotetracycline und Verfahren zu ihrer Verwendung
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3183267A (en) * 1962-09-06 1965-05-11 Pfizer & Co C 6-methylenetetracycline derivatives
GB1108310A (en) 1964-04-30 1968-04-03 Pfizer & Co C Derivatives of 6-methylene-tetracycline and process for their preparation
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (de) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
EP2327686A3 (de) 1999-09-14 2012-08-22 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Übergangschemien auf Metallbasis

Also Published As

Publication number Publication date
HUP0301429A2 (hu) 2003-09-29
EP1661883B1 (de) 2010-04-28
MXPA03000036A (es) 2003-07-14
EP1301465A2 (de) 2003-04-16
EP1661883A1 (de) 2006-05-31
KR20030017609A (ko) 2003-03-03
BR0112268A (pt) 2003-05-27
WO2002004405A3 (en) 2002-03-14
WO2002004405A2 (en) 2002-01-17
IL153674A0 (en) 2003-07-06
CA2415172A1 (en) 2002-01-17
HRP20030092A2 (en) 2004-06-30
AU2001271616A1 (en) 2002-01-21
EA200300136A1 (ru) 2003-06-26
JP2004502751A (ja) 2004-01-29
CZ2003332A3 (cs) 2003-05-14
ATE526308T1 (de) 2011-10-15
EP2204361B1 (de) 2011-09-28
EP2204361A1 (de) 2010-07-07
ATE465989T1 (de) 2010-05-15
CN1452611A (zh) 2003-10-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition