CN102070587B - 一锅法制备辛伐他汀的方法 - Google Patents
一锅法制备辛伐他汀的方法 Download PDFInfo
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- CN102070587B CN102070587B CN201110007231.1A CN201110007231A CN102070587B CN 102070587 B CN102070587 B CN 102070587B CN 201110007231 A CN201110007231 A CN 201110007231A CN 102070587 B CN102070587 B CN 102070587B
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- reaction
- acid
- alkali
- simvastatin
- hydroxyl
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- UILCPTPCECEDKM-UHFFFAOYSA-N CCC(C)(C)C(C=N)=O Chemical compound CCC(C)(C)C(C=N)=O UILCPTPCECEDKM-UHFFFAOYSA-N 0.000 description 1
Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
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Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201110007231.1A CN102070587B (zh) | 2011-01-13 | 2011-01-13 | 一锅法制备辛伐他汀的方法 |
Applications Claiming Priority (1)
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CN201110007231.1A CN102070587B (zh) | 2011-01-13 | 2011-01-13 | 一锅法制备辛伐他汀的方法 |
Publications (2)
Publication Number | Publication Date |
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CN102070587A CN102070587A (zh) | 2011-05-25 |
CN102070587B true CN102070587B (zh) | 2015-10-14 |
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Family Applications (1)
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CN201110007231.1A Active CN102070587B (zh) | 2011-01-13 | 2011-01-13 | 一锅法制备辛伐他汀的方法 |
Country Status (1)
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CN (1) | CN102070587B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2018013334A (es) * | 2016-05-04 | 2019-05-09 | Bayer Cropscience Ag | Metodo para producir derivados de espirociclicos cis-alcoxi-sustituidos 1-h-pirrolidina-2,4-diona. |
CN108558805A (zh) * | 2018-05-30 | 2018-09-21 | 日照市普达医药科技有限公司 | 一类血脂调节剂及其在防治心肌缺血中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI9800057A (sl) * | 1998-02-26 | 1999-08-31 | Krka, Tovarna Zdravil, D.D. | Postopek za pripravo simvastatina in njegovih derivatov |
WO2007096753A2 (en) * | 2006-02-21 | 2007-08-30 | Cadila Healthcare Limited | Process for preparing highly pure simvastatin |
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2011
- 2011-01-13 CN CN201110007231.1A patent/CN102070587B/zh active Active
Non-Patent Citations (1)
Title |
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《辛伐他汀的半合成》;任素梅等;《中国药物化学杂志》;20030228;第13卷(第1期);28-40 * |
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Publication number | Publication date |
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CN102070587A (zh) | 2011-05-25 |
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Address after: 523000 Songshan Industrial Zone, Songshan, Guangdong, Dongguan, Hubei Applicant after: Dongyangguang Pharmaceutical Co., Ltd., Guangdong Applicant after: YICHANG HEC CHANGJIANG PHARMACEUTICAL CO., LTD. Address before: 523000 Songshan Industrial Zone, Songshan, Guangdong, Dongguan, Hubei Applicant before: Dongyangguang Pharmaceutical Co., Ltd., Guangdong Applicant before: HEC Pharmaceutical Company |
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COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: YICHANG CHANGJIANG PHARMACEUTICAL CO., LTD. TO: YICHANG DONGYANGGUANG CHANGJIANG PHARMACEUTICAL CO., LTD. |
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C14 | Grant of patent or utility model | ||
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TR01 | Transfer of patent right |
Effective date of registration: 20200927 Address after: 443300, No. 38, Binjiang Road, Yidu, Hubei, Yichang Patentee after: YICHANG HEC CHANGJIANG PHARMACEUTICAL Co.,Ltd. Address before: 523000 Songshan Industrial Zone, Songshan, Guangdong, Dongguan, Hubei Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. Patentee before: YICHANG HEC CHANGJIANG PHARMACEUTICAL Co.,Ltd. |