ATE393151T1 - Laktonisierung im verfahren zur herstellung von statinen - Google Patents
Laktonisierung im verfahren zur herstellung von statinenInfo
- Publication number
- ATE393151T1 ATE393151T1 AT02015509T AT02015509T ATE393151T1 AT E393151 T1 ATE393151 T1 AT E393151T1 AT 02015509 T AT02015509 T AT 02015509T AT 02015509 T AT02015509 T AT 02015509T AT E393151 T1 ATE393151 T1 AT E393151T1
- Authority
- AT
- Austria
- Prior art keywords
- lactonization
- present
- simvastatin
- lovastatin
- statins
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000007273 lactonization reaction Methods 0.000 title abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract 2
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 abstract 2
- 229960004844 lovastatin Drugs 0.000 abstract 2
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract 2
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract 2
- 229960002855 simvastatin Drugs 0.000 abstract 2
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 abstract 2
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- BOZILQFLQYBIIY-INTXDZFKSA-N mevinic acid Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)CCC=C21 BOZILQFLQYBIIY-INTXDZFKSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2001-0051796A KR100407758B1 (ko) | 2001-08-27 | 2001-08-27 | 스타틴의 제조에 있어서 락톤화 방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE393151T1 true ATE393151T1 (de) | 2008-05-15 |
Family
ID=19713589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02015509T ATE393151T1 (de) | 2001-08-27 | 2002-07-10 | Laktonisierung im verfahren zur herstellung von statinen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6649775B2 (de) |
| EP (1) | EP1288212B1 (de) |
| JP (1) | JP2003096071A (de) |
| KR (1) | KR100407758B1 (de) |
| CN (1) | CN1193022C (de) |
| AT (1) | ATE393151T1 (de) |
| DE (1) | DE60226203T2 (de) |
| WO (1) | WO2003018570A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI21234A (sl) * | 2001-05-18 | 2003-12-31 | Aurobindo Pharma Limited | Postopek laktonizacije za proizvodnjo izredno čistega simvastatina |
| CA2515179A1 (en) | 2003-02-11 | 2004-08-26 | Ferenc Korodi | Process for preparing simvastatin having controlled ranges of simvastatin dimer content |
| CA2521095A1 (en) * | 2003-04-01 | 2004-10-21 | Plus Chemicals, B.V. | Amorphous simvastatin calcium and methods for the preparation thereof |
| WO2005095374A1 (en) * | 2004-03-30 | 2005-10-13 | Lupin Ltd. | An improved method for manufacture of 4-hydroxy pyran-2-one derivatives |
| US20060084817A1 (en) * | 2004-06-30 | 2006-04-20 | Chenault Henry K | Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging |
| EP1773838A1 (de) * | 2004-06-30 | 2007-04-18 | E.I.Du pont de nemours and company | Synthese von aldonolaktonen, aldarolaktonen und aldarodilakotonen durch durchperlen von gas |
| US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
| SG155189A1 (en) * | 2004-08-06 | 2009-09-30 | Transform Pharmaceuticals Inc | Novel fenofibrate formulations and related methods of treatment |
| KR20070038553A (ko) * | 2004-08-06 | 2007-04-10 | 트렌스폼 파마수티컬스 인코퍼레이티드 | 신규한 스타틴 약제학적 조성물 및 관련된 치료방법 |
| JO2897B1 (en) | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
| JP2009534459A (ja) * | 2006-04-26 | 2009-09-24 | ローズモント・フアーマシユーテイカルズ・リミテツド | 液体経口組成物 |
| JP2009114121A (ja) * | 2007-11-06 | 2009-05-28 | Kaneka Corp | シンバスタチンの製造方法 |
| CN101704808A (zh) * | 2009-11-20 | 2010-05-12 | 西南合成制药股份有限公司 | 制备他汀类化合物的内酯化方法 |
| CN103172603B (zh) * | 2011-12-22 | 2014-12-17 | 北大方正集团有限公司 | 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法 |
| CN103172602B (zh) * | 2011-12-22 | 2015-04-29 | 北大方正集团有限公司 | 一种纯化洛伐他汀的方法 |
| CN102875505B (zh) * | 2012-08-02 | 2015-08-05 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588820A (en) | 1984-06-11 | 1986-05-13 | Merck & Co., Inc. | Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
| US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
| IN186880B (de) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| ZA9810764B (en) * | 1998-04-22 | 1999-08-13 | Ranbaxy Lab Ltd | An improved process of lactonization in the preparation of statins. |
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| JP2000106835A (ja) * | 1998-09-30 | 2000-04-18 | Gunze Ltd | 紅麹及びその製造法 |
| SI20527A (sl) * | 1999-06-29 | 2001-10-31 | Kaneka Corporation | Postopek za selektivno laktonizacijo |
-
2001
- 2001-08-27 KR KR10-2001-0051796A patent/KR100407758B1/ko not_active Expired - Fee Related
-
2002
- 2002-07-06 WO PCT/KR2002/001281 patent/WO2003018570A1/en not_active Ceased
- 2002-07-10 DE DE60226203T patent/DE60226203T2/de not_active Expired - Lifetime
- 2002-07-10 EP EP02015509A patent/EP1288212B1/de not_active Expired - Lifetime
- 2002-07-10 AT AT02015509T patent/ATE393151T1/de not_active IP Right Cessation
- 2002-07-23 US US10/200,174 patent/US6649775B2/en not_active Expired - Fee Related
- 2002-07-29 CN CNB021270864A patent/CN1193022C/zh not_active Expired - Fee Related
- 2002-08-26 JP JP2002245931A patent/JP2003096071A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE60226203D1 (de) | 2008-06-05 |
| WO2003018570A1 (en) | 2003-03-06 |
| KR20030018202A (ko) | 2003-03-06 |
| EP1288212A1 (de) | 2003-03-05 |
| KR100407758B1 (ko) | 2003-12-01 |
| CN1406938A (zh) | 2003-04-02 |
| EP1288212B1 (de) | 2008-04-23 |
| JP2003096071A (ja) | 2003-04-03 |
| CN1193022C (zh) | 2005-03-16 |
| DE60226203T2 (de) | 2009-05-14 |
| US6649775B2 (en) | 2003-11-18 |
| US20030050482A1 (en) | 2003-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE393151T1 (de) | Laktonisierung im verfahren zur herstellung von statinen | |
| CY1112350T1 (el) | Διαδικασια παραγωγης ενος οπτικα ενεργου οξοεπτενοϊκου οξινου εστερα | |
| ATE353081T1 (de) | Verfahren zur herstellung von duloxetin und deren verwendeten zwischenprodukten | |
| DE60229267D1 (de) | Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen | |
| ATE543793T1 (de) | Verfahren zur herstellung von benzoesäureestern | |
| ATE521600T1 (de) | Verfahren zur herstellung von statinen | |
| HUP9901526A2 (hu) | Atorvastatin szintézis, közbenső termékei és eljárás ezek előállítására | |
| ATE359272T1 (de) | Verfahren zur herstellung von 3-hydroxy-n-1,6- | |
| DE69908909D1 (de) | Verfahren zur herstellung von simvastatin und ihren derivaten | |
| BR0208999A (pt) | Processo para a preparação de ácido de cefpodoxima | |
| DE69622862D1 (de) | Verfahren zur herstellung von zyklischen verbindungen | |
| DE50007399D1 (de) | Verfahren zur kontinuierlichen herstellung von glutaraldehyd | |
| DE60209289D1 (de) | Laktonisierungsverfahren bei der Herstellung von Statinen | |
| ATE314377T1 (de) | Verfahren zur herstellung von cephalosporin- verbindungen und zwischenprodukte für die synthese dieser verbindungen | |
| ATE390400T1 (de) | Verfahren zur herstellung von alpha'-chlorketonen | |
| RU2003128953A (ru) | Деградация эпотилонов | |
| ATE159016T1 (de) | Verfahren zur herstellung von 5-amino-2,2-dialkyl-1,3-dioxan | |
| ATE401298T1 (de) | Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin | |
| ATE296793T1 (de) | Verfahren zur herstellung von aliphatischen, zykloaliphatischen oder araliphatischen chlorameisensäureestern | |
| DE60040592D1 (de) | Verfahren zur herstellung von alpha-aminoketonen | |
| ATE156819T1 (de) | Verfahren zur herstellung einer oxazolidincarbon säure nützlich für die herstellung von therapeutischen taxoiden | |
| ATE387421T1 (de) | Verfahren zur herstellung von michael-addukten | |
| ATE267167T1 (de) | Verfahren zur herstellung von 7-azabicyclo (4.1.0)-hept-3-ene-3-carbonsäureestern | |
| ATE319722T1 (de) | Verfahren zur herstellung von vitamin-d analogen | |
| ATE197949T1 (de) | Verfahren zur herstellung von optisch aktivem (s)-(-)- und (r)-(+)- deoxyspergualin und zwischenprodukte dafür |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |