DE69908909D1 - Verfahren zur herstellung von simvastatin und ihren derivaten - Google Patents
Verfahren zur herstellung von simvastatin und ihren derivatenInfo
- Publication number
- DE69908909D1 DE69908909D1 DE69908909T DE69908909T DE69908909D1 DE 69908909 D1 DE69908909 D1 DE 69908909D1 DE 69908909 T DE69908909 T DE 69908909T DE 69908909 T DE69908909 T DE 69908909T DE 69908909 D1 DE69908909 D1 DE 69908909D1
- Authority
- DE
- Germany
- Prior art keywords
- protecting group
- formula
- derivatives
- diol lactone
- iia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9800057A SI9800057A (sl) | 1998-02-26 | 1998-02-26 | Postopek za pripravo simvastatina in njegovih derivatov |
PCT/SI1999/000006 WO1999043665A1 (en) | 1998-02-26 | 1999-02-24 | Process for the preparation of simvastatin and derivatives thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69908909D1 true DE69908909D1 (de) | 2003-07-24 |
DE69908909T2 DE69908909T2 (de) | 2003-12-04 |
Family
ID=20432210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69908909T Expired - Lifetime DE69908909T2 (de) | 1998-02-26 | 1999-02-24 | Verfahren zur herstellung von simvastatin und ihren derivaten |
Country Status (18)
Country | Link |
---|---|
US (1) | US6252091B1 (de) |
EP (1) | EP1056737B1 (de) |
AT (1) | ATE243207T1 (de) |
AU (1) | AU3284699A (de) |
BG (1) | BG64826B1 (de) |
CZ (1) | CZ297405B6 (de) |
DE (1) | DE69908909T2 (de) |
EA (1) | EA002370B1 (de) |
EE (1) | EE04345B1 (de) |
HR (1) | HRP20000467B1 (de) |
HU (1) | HU227916B1 (de) |
NO (1) | NO326301B1 (de) |
PL (1) | PL194713B1 (de) |
RS (1) | RS49712B (de) |
SI (1) | SI9800057A (de) |
SK (1) | SK284137B6 (de) |
UA (1) | UA56303C2 (de) |
WO (1) | WO1999043665A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20116A (sl) * | 1998-12-02 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov postopek za pripravo simvastatina in njegovih analogov |
EP1533308B1 (de) * | 1998-12-10 | 2014-01-15 | Kaneka Corporation | Verfahren zur Herstellung eines Simvastatin Precursors |
US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
WO2001034590A1 (en) | 1999-11-11 | 2001-05-17 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
AU2001282981B2 (en) | 2000-07-27 | 2004-08-05 | Plus Chemicals, B.V. | Highly purified simvastatin compositions |
US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
SK285772B6 (sk) * | 2002-11-20 | 2007-08-02 | Zentiva, A. S. | Spôsob prípravy simvastatínu |
CN102070587B (zh) * | 2011-01-13 | 2015-10-14 | 广东东阳光药业有限公司 | 一锅法制备辛伐他汀的方法 |
US9499621B2 (en) | 2013-04-08 | 2016-11-22 | Cytodyn, Inc. | Felinized antibodies and methods of treating retroviral infections in felines |
CN104311517B (zh) * | 2014-10-17 | 2017-06-06 | 上海应用技术学院 | 他汀内酯脱水化合物及其用途 |
CN104356120B (zh) * | 2014-10-17 | 2017-05-03 | 上海应用技术学院 | 多取代喹啉类他汀内酯脱水化合物及其用途 |
CN105111173B (zh) * | 2015-06-26 | 2017-06-23 | 上海应用技术学院 | 他汀含氟衍生物及其用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR69216B (de) | 1979-06-15 | 1982-05-07 | Merck & Co Inc | |
US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
EP0137445B1 (de) * | 1983-10-11 | 1990-01-03 | Merck & Co. Inc. | Verfahren zur C-Methylierung von 2-Methylbutyraten |
US4845237A (en) * | 1987-04-15 | 1989-07-04 | Merck & Co., Inc. | Acylation process for the synthesis of HMG-CoA reductase inhibitors |
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
CA2036962C (en) | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
US5223415A (en) * | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
SI9500238A (en) | 1995-07-27 | 1997-02-28 | Krka Tovarna Zdravil | Procedure for the production of lovastatin |
-
1998
- 1998-02-26 SI SI9800057A patent/SI9800057A/sl unknown
-
1999
- 1999-02-24 RS YUP-466/00A patent/RS49712B/sr unknown
- 1999-02-24 CZ CZ20002857A patent/CZ297405B6/cs not_active IP Right Cessation
- 1999-02-24 WO PCT/SI1999/000006 patent/WO1999043665A1/en active IP Right Grant
- 1999-02-24 PL PL99342511A patent/PL194713B1/pl unknown
- 1999-02-24 UA UA2000095504A patent/UA56303C2/uk unknown
- 1999-02-24 EE EEP200000479A patent/EE04345B1/xx not_active IP Right Cessation
- 1999-02-24 AT AT99936072T patent/ATE243207T1/de not_active IP Right Cessation
- 1999-02-24 AU AU32846/99A patent/AU3284699A/en not_active Abandoned
- 1999-02-24 SK SK1258-2000A patent/SK284137B6/sk not_active IP Right Cessation
- 1999-02-24 EP EP99936072A patent/EP1056737B1/de not_active Expired - Lifetime
- 1999-02-24 HU HU0100743A patent/HU227916B1/hu not_active IP Right Cessation
- 1999-02-24 DE DE69908909T patent/DE69908909T2/de not_active Expired - Lifetime
- 1999-02-24 EA EA200000881A patent/EA002370B1/ru not_active IP Right Cessation
-
2000
- 2000-07-07 HR HR20000467A patent/HRP20000467B1/xx not_active IP Right Cessation
- 2000-08-23 NO NO20004221A patent/NO326301B1/no not_active IP Right Cessation
- 2000-09-05 BG BG104749A patent/BG64826B1/bg unknown
- 2000-09-22 US US09/668,101 patent/US6252091B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HU227916B1 (en) | 2012-06-28 |
CZ20002857A3 (cs) | 2000-11-15 |
CZ297405B6 (cs) | 2006-12-13 |
EP1056737A1 (de) | 2000-12-06 |
NO326301B1 (no) | 2008-11-03 |
BG64826B1 (bg) | 2006-05-31 |
PL342511A1 (en) | 2001-06-18 |
HRP20000467B1 (en) | 2009-02-28 |
HUP0100743A2 (hu) | 2001-11-28 |
EE200000479A (et) | 2002-02-15 |
SK284137B6 (sk) | 2004-09-08 |
EA002370B1 (ru) | 2002-04-25 |
SI9800057A (sl) | 1999-08-31 |
HRP20000467A2 (en) | 2001-02-28 |
UA56303C2 (uk) | 2003-05-15 |
WO1999043665A1 (en) | 1999-09-02 |
NO20004221D0 (no) | 2000-08-23 |
ATE243207T1 (de) | 2003-07-15 |
EA200000881A1 (ru) | 2001-02-26 |
RS49712B (sr) | 2007-12-31 |
BG104749A (en) | 2001-04-30 |
NO20004221L (no) | 2000-08-23 |
US6252091B1 (en) | 2001-06-26 |
YU46600A (sh) | 2003-12-31 |
EE04345B1 (et) | 2004-08-16 |
EP1056737B1 (de) | 2003-06-18 |
DE69908909T2 (de) | 2003-12-04 |
AU3284699A (en) | 1999-09-15 |
HUP0100743A3 (en) | 2002-04-29 |
PL194713B1 (pl) | 2007-06-29 |
SK12582000A3 (sk) | 2002-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |