CA2108265A1 - Methods and compositions for isolating taxanes - Google Patents

Methods and compositions for isolating taxanes

Info

Publication number
CA2108265A1
CA2108265A1 CA002108265A CA2108265A CA2108265A1 CA 2108265 A1 CA2108265 A1 CA 2108265A1 CA 002108265 A CA002108265 A CA 002108265A CA 2108265 A CA2108265 A CA 2108265A CA 2108265 A1 CA2108265 A1 CA 2108265A1
Authority
CA
Canada
Prior art keywords
taxanes
methods
disclosed
compositions
taxol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002108265A
Other languages
French (fr)
Other versions
CA2108265C (en
Inventor
Hala N. Eisohly
Edward M. Croom, Jr.
Mahmoud A. Eisohly
James D. Mcchesney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Mississippi
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1992/003088 external-priority patent/WO1992018492A1/en
Publication of CA2108265A1 publication Critical patent/CA2108265A1/en
Application granted granted Critical
Publication of CA2108265C publication Critical patent/CA2108265C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of drying plant matter to preserve their taxane content and facilitate their extraction is disclosed. In addition, methods of extracting and purifying taxol and other taxanes from ornamental cultivars using a series of organic and aqueous solvents and normal phase chromatography columns are also disclosed.
CA002108265A 1991-04-19 1992-04-14 Methods and compositions for isolating taxanes Expired - Fee Related CA2108265C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69080591A 1991-04-19 1991-04-19
US07/690,805 1991-04-19
PCT/US1992/003088 WO1992018492A1 (en) 1991-04-19 1992-04-14 Methods and compositions for isolating taxanes

Publications (2)

Publication Number Publication Date
CA2108265A1 true CA2108265A1 (en) 1992-10-20
CA2108265C CA2108265C (en) 2006-12-05

Family

ID=37558502

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108265A Expired - Fee Related CA2108265C (en) 1991-04-19 1992-04-14 Methods and compositions for isolating taxanes

Country Status (1)

Country Link
CA (1) CA2108265C (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878832B2 (en) 2000-11-13 2005-04-12 Lahu Saiji Isolation of taxanes
WO2007045093A1 (en) * 2005-10-21 2007-04-26 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service Preparation of taxanes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878832B2 (en) 2000-11-13 2005-04-12 Lahu Saiji Isolation of taxanes
WO2007045093A1 (en) * 2005-10-21 2007-04-26 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service Preparation of taxanes

Also Published As

Publication number Publication date
CA2108265C (en) 2006-12-05

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