EE04345B1 - Simvastatiini ja selle derivaatide valmistamise protsess - Google Patents

Simvastatiini ja selle derivaatide valmistamise protsess

Info

Publication number
EE04345B1
EE04345B1 EEP200000479A EEP200000479A EE04345B1 EE 04345 B1 EE04345 B1 EE 04345B1 EE P200000479 A EEP200000479 A EE P200000479A EE P200000479 A EEP200000479 A EE P200000479A EE 04345 B1 EE04345 B1 EE 04345B1
Authority
EE
Estonia
Prior art keywords
protecting group
formula
preparation
simvastatin
derivatives
Prior art date
Application number
EEP200000479A
Other languages
English (en)
Inventor
Zupancic Silvo
�timac Anton
Gnidovec Joze
Original Assignee
Krka, Tovarna Zdravil, D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, Tovarna Zdravil, D.D. filed Critical Krka, Tovarna Zdravil, D.D.
Publication of EE200000479A publication Critical patent/EE200000479A/et
Publication of EE04345B1 publication Critical patent/EE04345B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
EEP200000479A 1998-02-26 1999-02-24 Simvastatiini ja selle derivaatide valmistamise protsess EE04345B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov
PCT/SI1999/000006 WO1999043665A1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof

Publications (2)

Publication Number Publication Date
EE200000479A EE200000479A (et) 2002-02-15
EE04345B1 true EE04345B1 (et) 2004-08-16

Family

ID=20432210

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000479A EE04345B1 (et) 1998-02-26 1999-02-24 Simvastatiini ja selle derivaatide valmistamise protsess

Country Status (18)

Country Link
US (1) US6252091B1 (et)
EP (1) EP1056737B1 (et)
AT (1) ATE243207T1 (et)
AU (1) AU3284699A (et)
BG (1) BG64826B1 (et)
CZ (1) CZ297405B6 (et)
DE (1) DE69908909T2 (et)
EA (1) EA002370B1 (et)
EE (1) EE04345B1 (et)
HR (1) HRP20000467B1 (et)
HU (1) HU227916B1 (et)
NO (1) NO326301B1 (et)
PL (1) PL194713B1 (et)
RS (1) RS49712B (et)
SI (1) SI9800057A (et)
SK (1) SK284137B6 (et)
UA (1) UA56303C2 (et)
WO (1) WO1999043665A1 (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
EP1055671B1 (en) * 1998-12-10 2004-12-01 Kaneka Corporation A process for producing a simvastatin precursor
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
IL154068A0 (en) 2000-07-27 2003-07-31 Teva Pharma Highly purified simvastatin compositions
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
SK285772B6 (sk) * 2002-11-20 2007-08-02 Zentiva, A. S. Spôsob prípravy simvastatínu
CN102070587B (zh) * 2011-01-13 2015-10-14 广东东阳光药业有限公司 一锅法制备辛伐他汀的方法
EP2983711A4 (en) 2013-04-08 2016-11-23 Cytodyn Inc FELLINED ANTIBODIES AND METHODS OF TREATING RETROVIRAL INFECTIONS IN FELINES
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途
CN104356120B (zh) * 2014-10-17 2017-05-03 上海应用技术学院 多取代喹啉类他汀内酯脱水化合物及其用途
CN105111173B (zh) * 2015-06-26 2017-06-23 上海应用技术学院 他汀含氟衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60219A (en) 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
EP0137445B1 (en) * 1983-10-11 1990-01-03 Merck & Co. Inc. Process for c-methylation of 2-methylbutyrates
US4845237A (en) * 1987-04-15 1989-07-04 Merck & Co., Inc. Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
CA2036962C (en) 1990-02-26 1998-09-15 Ann E. Decamp Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI9500238A (en) 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin

Also Published As

Publication number Publication date
WO1999043665A1 (en) 1999-09-02
HUP0100743A3 (en) 2002-04-29
BG104749A (en) 2001-04-30
NO326301B1 (no) 2008-11-03
CZ297405B6 (cs) 2006-12-13
EE200000479A (et) 2002-02-15
EP1056737B1 (en) 2003-06-18
DE69908909T2 (de) 2003-12-04
US6252091B1 (en) 2001-06-26
NO20004221D0 (no) 2000-08-23
EP1056737A1 (en) 2000-12-06
PL194713B1 (pl) 2007-06-29
PL342511A1 (en) 2001-06-18
HU227916B1 (en) 2012-06-28
EA002370B1 (ru) 2002-04-25
HUP0100743A2 (hu) 2001-11-28
HRP20000467B1 (en) 2009-02-28
DE69908909D1 (de) 2003-07-24
BG64826B1 (bg) 2006-05-31
CZ20002857A3 (cs) 2000-11-15
UA56303C2 (uk) 2003-05-15
RS49712B (sr) 2007-12-31
EA200000881A1 (ru) 2001-02-26
NO20004221L (no) 2000-08-23
SI9800057A (sl) 1999-08-31
SK284137B6 (sk) 2004-09-08
YU46600A (sh) 2003-12-31
ATE243207T1 (de) 2003-07-15
AU3284699A (en) 1999-09-15
SK12582000A3 (sk) 2002-01-07
HRP20000467A2 (en) 2001-02-28

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110224