SK284137B6 - Spôsob prípravy simvastatínu a jeho derivátov - Google Patents
Spôsob prípravy simvastatínu a jeho derivátov Download PDFInfo
- Publication number
- SK284137B6 SK284137B6 SK1258-2000A SK12582000A SK284137B6 SK 284137 B6 SK284137 B6 SK 284137B6 SK 12582000 A SK12582000 A SK 12582000A SK 284137 B6 SK284137 B6 SK 284137B6
- Authority
- SK
- Slovakia
- Prior art keywords
- process according
- lactone
- formula
- group
- protecting group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800057A SI9800057A (sl) | 1998-02-26 | 1998-02-26 | Postopek za pripravo simvastatina in njegovih derivatov |
| PCT/SI1999/000006 WO1999043665A1 (en) | 1998-02-26 | 1999-02-24 | Process for the preparation of simvastatin and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK12582000A3 SK12582000A3 (sk) | 2002-01-07 |
| SK284137B6 true SK284137B6 (sk) | 2004-09-08 |
Family
ID=20432210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1258-2000A SK284137B6 (sk) | 1998-02-26 | 1999-02-24 | Spôsob prípravy simvastatínu a jeho derivátov |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6252091B1 (et) |
| EP (1) | EP1056737B1 (et) |
| AT (1) | ATE243207T1 (et) |
| AU (1) | AU3284699A (et) |
| BG (1) | BG64826B1 (et) |
| CZ (1) | CZ297405B6 (et) |
| DE (1) | DE69908909T2 (et) |
| EA (1) | EA002370B1 (et) |
| EE (1) | EE04345B1 (et) |
| HR (1) | HRP20000467B1 (et) |
| HU (1) | HU227916B1 (et) |
| NO (1) | NO326301B1 (et) |
| PL (1) | PL194713B1 (et) |
| RS (1) | RS49712B (et) |
| SI (1) | SI9800057A (et) |
| SK (1) | SK284137B6 (et) |
| UA (1) | UA56303C2 (et) |
| WO (1) | WO1999043665A1 (et) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20116A (sl) * | 1998-12-02 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Nov postopek za pripravo simvastatina in njegovih analogov |
| EP1055671B1 (en) * | 1998-12-10 | 2004-12-01 | Kaneka Corporation | A process for producing a simvastatin precursor |
| AU2127500A (en) | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
| US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
| IL154068A0 (en) | 2000-07-27 | 2003-07-31 | Teva Pharma | Highly purified simvastatin compositions |
| US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
| SK285772B6 (sk) * | 2002-11-20 | 2007-08-02 | Zentiva, A. S. | Spôsob prípravy simvastatínu |
| CN102070587B (zh) * | 2011-01-13 | 2015-10-14 | 广东东阳光药业有限公司 | 一锅法制备辛伐他汀的方法 |
| WO2014168933A1 (en) | 2013-04-08 | 2014-10-16 | Cytodyn Inc. | Felinized antibodies and methods of treating retroviral infections in felines |
| CN104356120B (zh) * | 2014-10-17 | 2017-05-03 | 上海应用技术学院 | 多取代喹啉类他汀内酯脱水化合物及其用途 |
| CN104311517B (zh) * | 2014-10-17 | 2017-06-06 | 上海应用技术学院 | 他汀内酯脱水化合物及其用途 |
| CN105111173B (zh) * | 2015-06-26 | 2017-06-23 | 上海应用技术学院 | 他汀含氟衍生物及其用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU535944B2 (en) | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| EP0137445B1 (en) * | 1983-10-11 | 1990-01-03 | Merck & Co. Inc. | Process for c-methylation of 2-methylbutyrates |
| US4845237A (en) * | 1987-04-15 | 1989-07-04 | Merck & Co., Inc. | Acylation process for the synthesis of HMG-CoA reductase inhibitors |
| US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| CA2036962C (en) | 1990-02-26 | 1998-09-15 | Ann E. Decamp | Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one |
| US5223415A (en) * | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
| SI9500238A (en) | 1995-07-27 | 1997-02-28 | Krka Tovarna Zdravil | Procedure for the production of lovastatin |
-
1998
- 1998-02-26 SI SI9800057A patent/SI9800057A/sl unknown
-
1999
- 1999-02-24 UA UA2000095504A patent/UA56303C2/uk unknown
- 1999-02-24 PL PL99342511A patent/PL194713B1/pl unknown
- 1999-02-24 SK SK1258-2000A patent/SK284137B6/sk not_active IP Right Cessation
- 1999-02-24 HU HU0100743A patent/HU227916B1/hu not_active IP Right Cessation
- 1999-02-24 DE DE69908909T patent/DE69908909T2/de not_active Expired - Lifetime
- 1999-02-24 EA EA200000881A patent/EA002370B1/ru not_active IP Right Cessation
- 1999-02-24 WO PCT/SI1999/000006 patent/WO1999043665A1/en active IP Right Grant
- 1999-02-24 CZ CZ20002857A patent/CZ297405B6/cs not_active IP Right Cessation
- 1999-02-24 EE EEP200000479A patent/EE04345B1/et not_active IP Right Cessation
- 1999-02-24 AU AU32846/99A patent/AU3284699A/en not_active Abandoned
- 1999-02-24 EP EP99936072A patent/EP1056737B1/en not_active Expired - Lifetime
- 1999-02-24 AT AT99936072T patent/ATE243207T1/de not_active IP Right Cessation
- 1999-02-24 RS YUP-466/00A patent/RS49712B/sr unknown
-
2000
- 2000-07-07 HR HR20000467A patent/HRP20000467B1/xx not_active IP Right Cessation
- 2000-08-23 NO NO20004221A patent/NO326301B1/no not_active IP Right Cessation
- 2000-09-05 BG BG104749A patent/BG64826B1/bg unknown
- 2000-09-22 US US09/668,101 patent/US6252091B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1056737B1 (en) | 2003-06-18 |
| EA002370B1 (ru) | 2002-04-25 |
| UA56303C2 (uk) | 2003-05-15 |
| BG104749A (en) | 2001-04-30 |
| CZ20002857A3 (cs) | 2000-11-15 |
| EP1056737A1 (en) | 2000-12-06 |
| HUP0100743A2 (hu) | 2001-11-28 |
| HRP20000467A2 (en) | 2001-02-28 |
| HUP0100743A3 (en) | 2002-04-29 |
| SI9800057A (sl) | 1999-08-31 |
| CZ297405B6 (cs) | 2006-12-13 |
| HRP20000467B1 (en) | 2009-02-28 |
| BG64826B1 (bg) | 2006-05-31 |
| US6252091B1 (en) | 2001-06-26 |
| EE04345B1 (et) | 2004-08-16 |
| NO20004221D0 (no) | 2000-08-23 |
| AU3284699A (en) | 1999-09-15 |
| HU227916B1 (en) | 2012-06-28 |
| DE69908909T2 (de) | 2003-12-04 |
| NO20004221L (no) | 2000-08-23 |
| WO1999043665A1 (en) | 1999-09-02 |
| SK12582000A3 (sk) | 2002-01-07 |
| PL342511A1 (en) | 2001-06-18 |
| ATE243207T1 (de) | 2003-07-15 |
| EE200000479A (et) | 2002-02-15 |
| NO326301B1 (no) | 2008-11-03 |
| YU46600A (sh) | 2003-12-31 |
| DE69908909D1 (de) | 2003-07-24 |
| RS49712B (sr) | 2007-12-31 |
| EA200000881A1 (ru) | 2001-02-26 |
| PL194713B1 (pl) | 2007-06-29 |
Similar Documents
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| US5393893A (en) | Process for producing simvastatin and analogs thereof | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of maintenance fees |
Effective date: 20140224 |