SI9800057A - Postopek za pripravo simvastatina in njegovih derivatov - Google Patents

Postopek za pripravo simvastatina in njegovih derivatov Download PDF

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Publication number
SI9800057A
SI9800057A SI9800057A SI9800057A SI9800057A SI 9800057 A SI9800057 A SI 9800057A SI 9800057 A SI9800057 A SI 9800057A SI 9800057 A SI9800057 A SI 9800057A SI 9800057 A SI9800057 A SI 9800057A
Authority
SI
Slovenia
Prior art keywords
process according
formula
protecting group
reaction
diol lactone
Prior art date
Application number
SI9800057A
Other languages
English (en)
Slovenian (sl)
Inventor
Silvo ZUPAN�I�
Anton Timac
Jo�e Gnidovec
Original Assignee
Krka, Tovarna Zdravil, D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka, Tovarna Zdravil, D.D. filed Critical Krka, Tovarna Zdravil, D.D.
Priority to SI9800057A priority Critical patent/SI9800057A/sl
Priority to PL99342511A priority patent/PL194713B1/pl
Priority to EP99936072A priority patent/EP1056737B1/en
Priority to CZ20002857A priority patent/CZ297405B6/cs
Priority to UA2000095504A priority patent/UA56303C2/uk
Priority to HU0100743A priority patent/HU227916B1/hu
Priority to AU32846/99A priority patent/AU3284699A/en
Priority to YUP-466/00A priority patent/RS49712B/sr
Priority to EA200000881A priority patent/EA002370B1/ru
Priority to EEP200000479A priority patent/EE04345B1/et
Priority to PCT/SI1999/000006 priority patent/WO1999043665A1/en
Priority to SI9930345T priority patent/SI1056737T1/xx
Priority to SK1258-2000A priority patent/SK284137B6/sk
Priority to AT99936072T priority patent/ATE243207T1/de
Priority to DE69908909T priority patent/DE69908909T2/de
Publication of SI9800057A publication Critical patent/SI9800057A/sl
Priority to HR20000467A priority patent/HRP20000467B1/xx
Priority to NO20004221A priority patent/NO326301B1/no
Priority to BG104749A priority patent/BG64826B1/bg
Priority to US09/668,101 priority patent/US6252091B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI9800057A 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov SI9800057A (sl)

Priority Applications (19)

Application Number Priority Date Filing Date Title
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov
EEP200000479A EE04345B1 (et) 1998-02-26 1999-02-24 Simvastatiini ja selle derivaatide valmistamise protsess
PCT/SI1999/000006 WO1999043665A1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof
CZ20002857A CZ297405B6 (cs) 1998-02-26 1999-02-24 Zpusob prípravy simvastatinu a jeho derivátu
UA2000095504A UA56303C2 (uk) 1998-02-26 1999-02-24 Спосіб одержання симвастатину та його похідних
HU0100743A HU227916B1 (en) 1998-02-26 1999-02-24 Process for preparation of simvastatin and derivatives thereof
AU32846/99A AU3284699A (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof
YUP-466/00A RS49712B (sr) 1998-02-26 1999-02-24 Postupak za dobijanje simvastatina i njegovih derivata
EA200000881A EA002370B1 (ru) 1998-02-26 1999-02-24 Способ получения симвастатина и его производных
PL99342511A PL194713B1 (pl) 1998-02-26 1999-02-24 Sposób otrzymywania symwastatyny i jej pochodnych
EP99936072A EP1056737B1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof
SI9930345T SI1056737T1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof
SK1258-2000A SK284137B6 (sk) 1998-02-26 1999-02-24 Spôsob prípravy simvastatínu a jeho derivátov
AT99936072T ATE243207T1 (de) 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten
DE69908909T DE69908909T2 (de) 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten
HR20000467A HRP20000467B1 (en) 1998-02-26 2000-07-07 Process for the preparation of simvastatin and derivatives thereof
NO20004221A NO326301B1 (no) 1998-02-26 2000-08-23 Fremgangsmate for fremstilling av simvastatin og derivater derav
BG104749A BG64826B1 (bg) 1998-02-26 2000-09-05 Метод за получаване на симвастатин и негови производни
US09/668,101 US6252091B1 (en) 1998-02-26 2000-09-22 Process for the preparation of simvastatin and derivatives thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov

Publications (1)

Publication Number Publication Date
SI9800057A true SI9800057A (sl) 1999-08-31

Family

ID=20432210

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov

Country Status (18)

Country Link
US (1) US6252091B1 (et)
EP (1) EP1056737B1 (et)
AT (1) ATE243207T1 (et)
AU (1) AU3284699A (et)
BG (1) BG64826B1 (et)
CZ (1) CZ297405B6 (et)
DE (1) DE69908909T2 (et)
EA (1) EA002370B1 (et)
EE (1) EE04345B1 (et)
HR (1) HRP20000467B1 (et)
HU (1) HU227916B1 (et)
NO (1) NO326301B1 (et)
PL (1) PL194713B1 (et)
RS (1) RS49712B (et)
SI (1) SI9800057A (et)
SK (1) SK284137B6 (et)
UA (1) UA56303C2 (et)
WO (1) WO1999043665A1 (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
AU1683000A (en) * 1998-12-10 2000-06-26 Kaneka Corporation Process for producing simvastatin
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
US6573392B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
CN1446088A (zh) 2000-07-27 2003-10-01 普拉斯化学品有限公司 高度纯化的辛伐他汀组合物
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
SK285772B6 (sk) * 2002-11-20 2007-08-02 Zentiva, A. S. Spôsob prípravy simvastatínu
CN102070587B (zh) * 2011-01-13 2015-10-14 广东东阳光药业有限公司 一锅法制备辛伐他汀的方法
WO2014168933A1 (en) 2013-04-08 2014-10-16 Cytodyn Inc. Felinized antibodies and methods of treating retroviral infections in felines
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途
CN104356120B (zh) * 2014-10-17 2017-05-03 上海应用技术学院 多取代喹啉类他汀内酯脱水化合物及其用途
CN105111173B (zh) * 2015-06-26 2017-06-23 上海应用技术学院 他汀含氟衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69216B (et) 1979-06-15 1982-05-07 Merck & Co Inc
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4845237A (en) * 1987-04-15 1989-07-04 Merck & Co., Inc. Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
CA2036962C (en) 1990-02-26 1998-09-15 Ann E. Decamp Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI9500238A (en) 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin

Also Published As

Publication number Publication date
NO20004221D0 (no) 2000-08-23
HRP20000467B1 (en) 2009-02-28
AU3284699A (en) 1999-09-15
RS49712B (sr) 2007-12-31
CZ297405B6 (cs) 2006-12-13
EA200000881A1 (ru) 2001-02-26
UA56303C2 (uk) 2003-05-15
SK284137B6 (sk) 2004-09-08
DE69908909D1 (de) 2003-07-24
PL342511A1 (en) 2001-06-18
US6252091B1 (en) 2001-06-26
HRP20000467A2 (en) 2001-02-28
HUP0100743A2 (hu) 2001-11-28
SK12582000A3 (sk) 2002-01-07
EP1056737B1 (en) 2003-06-18
DE69908909T2 (de) 2003-12-04
NO20004221L (no) 2000-08-23
BG64826B1 (bg) 2006-05-31
WO1999043665A1 (en) 1999-09-02
EA002370B1 (ru) 2002-04-25
HUP0100743A3 (en) 2002-04-29
HU227916B1 (en) 2012-06-28
YU46600A (sh) 2003-12-31
PL194713B1 (pl) 2007-06-29
CZ20002857A3 (cs) 2000-11-15
BG104749A (en) 2001-04-30
ATE243207T1 (de) 2003-07-15
EE04345B1 (et) 2004-08-16
EP1056737A1 (en) 2000-12-06
EE200000479A (et) 2002-02-15
NO326301B1 (no) 2008-11-03

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