RU95112573A - Способ получения 9-аминокамптотецина, промежуточные продукты, способ их получения и фармкомпозиция - Google Patents
Способ получения 9-аминокамптотецина, промежуточные продукты, способ их получения и фармкомпозицияInfo
- Publication number
- RU95112573A RU95112573A RU95112573/04A RU95112573A RU95112573A RU 95112573 A RU95112573 A RU 95112573A RU 95112573/04 A RU95112573/04 A RU 95112573/04A RU 95112573 A RU95112573 A RU 95112573A RU 95112573 A RU95112573 A RU 95112573A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- compound
- camptothecine
- synthesis
- amino
- Prior art date
Links
- 0 CC[C@](C1C=C2c3nc(c(I)ccc4)c4cc3C*22)(C(O)OCC1C2=O)O Chemical compound CC[C@](C1C=C2c3nc(c(I)ccc4)c4cc3C*22)(C(O)OCC1C2=O)O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
9-амино-20 (S) -камптотецин формулы I получают восстановлением 12-нитро-20(S)-камптотецина формулы II, превращением, получающегося 12-амино-20 (S) -камптотецина формулы III в соединение формулы IV. Формулы I-IV приведены в описании.
Claims (1)
- 9-амино-20 (S) -камптотецин формулы I получают восстановлением 12-нитро-20(S)-камптотецина формулы II, превращением, получающегося 12-амино-20 (S) -камптотецина формулы III в соединение формулы IV. Формулы I-IV приведены в описании.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9316352.5 | 1993-08-06 | ||
GB939316352A GB9316352D0 (en) | 1993-08-06 | 1993-08-06 | Process for the preparation of 9-amino camptothecin |
PCT/EP1994/002370 WO1995004736A1 (en) | 1993-08-06 | 1994-07-18 | Process for the preparation of 9-amino camptothecin |
Publications (2)
Publication Number | Publication Date |
---|---|
RU95112573A true RU95112573A (ru) | 1997-02-20 |
RU2145325C1 RU2145325C1 (ru) | 2000-02-10 |
Family
ID=10740090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95112573A RU2145325C1 (ru) | 1993-08-06 | 1994-07-18 | Способы получения 9-аминокамптотецина, промежуточные продукты и способ их получения |
Country Status (15)
Country | Link |
---|---|
US (1) | US6403603B1 (ru) |
EP (1) | EP0663914A1 (ru) |
JP (2) | JP3556223B2 (ru) |
KR (1) | KR950703565A (ru) |
CN (1) | CN1048296C (ru) |
AU (1) | AU678587B2 (ru) |
CA (1) | CA2145514C (ru) |
FI (1) | FI951581A (ru) |
GB (1) | GB9316352D0 (ru) |
HU (1) | HUT71240A (ru) |
IL (1) | IL110553A (ru) |
RU (1) | RU2145325C1 (ru) |
TW (1) | TW269691B (ru) |
WO (1) | WO1995004736A1 (ru) |
ZA (1) | ZA945878B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9319944D0 (en) * | 1993-09-28 | 1993-11-17 | Erba Carlo Spa | Process for the preparation of 9-amino camptothecin |
GB9410388D0 (en) * | 1994-05-24 | 1994-07-13 | Erba Carlo Spa | Method for the preparation of 9-amino camptothecin |
CN1324032C (zh) * | 2004-01-07 | 2007-07-04 | 重庆医药工业研究院有限责任公司 | 一种新的9-硝基喜树碱晶型和药物组合物 |
CN1312155C (zh) * | 2005-01-21 | 2007-04-25 | 华东理工大学 | 一种分离纯化9-硝基喜树碱的方法 |
CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2150234A1 (de) * | 1971-10-08 | 1973-04-12 | Basf Ag | Verfahren zur herstellung von camptothecin und camptothecin-derivaten |
US4894456A (en) * | 1987-03-31 | 1990-01-16 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
US5180722A (en) * | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
US5225404A (en) * | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
DE4134885C2 (de) * | 1991-10-23 | 1994-04-07 | Praezisions Ventil Gmbh | Betätigungsaufsatz für einen Sprühbehälter |
-
1993
- 1993-08-06 GB GB939316352A patent/GB9316352D0/en active Pending
-
1994
- 1994-07-18 KR KR1019950701312A patent/KR950703565A/ko not_active Application Discontinuation
- 1994-07-18 JP JP50617895A patent/JP3556223B2/ja not_active Expired - Fee Related
- 1994-07-18 AU AU72290/94A patent/AU678587B2/en not_active Ceased
- 1994-07-18 EP EP94921656A patent/EP0663914A1/en not_active Withdrawn
- 1994-07-18 RU RU95112573A patent/RU2145325C1/ru active
- 1994-07-18 WO PCT/EP1994/002370 patent/WO1995004736A1/en not_active Application Discontinuation
- 1994-07-18 HU HU9501319A patent/HUT71240A/hu unknown
- 1994-07-18 CA CA002145514A patent/CA2145514C/en not_active Expired - Fee Related
- 1994-07-18 CN CN94190581A patent/CN1048296C/zh not_active Expired - Fee Related
- 1994-08-02 US US08/284,129 patent/US6403603B1/en not_active Expired - Fee Related
- 1994-08-03 TW TW083107096A patent/TW269691B/zh active
- 1994-08-03 IL IL110553A patent/IL110553A/xx not_active IP Right Cessation
- 1994-08-05 ZA ZA945878A patent/ZA945878B/xx unknown
-
1995
- 1995-04-03 FI FI951581A patent/FI951581A/fi unknown
-
2004
- 2004-03-01 JP JP2004055749A patent/JP2004217665A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CN1113384A (zh) | 1995-12-13 |
FI951581A0 (fi) | 1995-04-03 |
JPH08506597A (ja) | 1996-07-16 |
IL110553A0 (en) | 1994-11-11 |
RU2145325C1 (ru) | 2000-02-10 |
GB9316352D0 (en) | 1993-09-22 |
HUT71240A (en) | 1995-11-28 |
KR950703565A (ko) | 1995-09-20 |
TW269691B (ru) | 1996-02-01 |
AU678587B2 (en) | 1997-06-05 |
CA2145514C (en) | 2006-06-06 |
CA2145514A1 (en) | 1995-02-16 |
CN1048296C (zh) | 2000-01-12 |
FI951581A (fi) | 1995-04-03 |
AU7229094A (en) | 1995-02-28 |
JP2004217665A (ja) | 2004-08-05 |
EP0663914A1 (en) | 1995-07-26 |
US6403603B1 (en) | 2002-06-11 |
IL110553A (en) | 1997-03-18 |
WO1995004736A1 (en) | 1995-02-16 |
JP3556223B2 (ja) | 2004-08-18 |
ZA945878B (en) | 1995-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL109526A0 (en) | Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them | |
RU92016313A (ru) | Новые аналоги витамина d, способ их получения, промежуточное соединение, формкомпозиция и способ лечения | |
CA2046126A1 (en) | 2-thienylglycidic derivative, process for its preparation and its use as synthesis intermediate | |
ES8103088A1 (es) | Metodo para preparar nuevas espiro(dihidrobenzofuran-piperi-dinas y -pirrolidinas) | |
CA2035038A1 (en) | Synthetic intermediates of 2-alkynyladenosines, processes for preparing the synthetic intermediates, processes for preparing 2-alkynyladenosines utilizing the synthetic intermediates, and stable 2-alkynyladenosine derivatives | |
CA2199128A1 (en) | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | |
BR0109048A (pt) | Processo para a sìntese de citalopram | |
IL112020A0 (en) | Arylacetic acid derivatives, their preparation and their use as fungicides | |
CA2080249A1 (en) | Preparation of substituted piperidines | |
CA2133885A1 (en) | Crystalline inclusion complex of diclofenac with beta-cyclodextrin | |
CA2155323A1 (en) | Novel use as anti-inflammatory agents for bis-heterocyclic compounds and pharmaceutical compositions thereof | |
AU628521B2 (en) | Improvements in or relating to organic compounds | |
ES2144885T3 (es) | Empleo como un fungicida de derivados de acido beta-amino-propionico. | |
CA2226406A1 (en) | Novel pyridone carboxylic acid derivatives | |
CA2256718A1 (en) | Dihydrobenzopyran and related compounds useful as anti-inflammatory agents | |
CA2191874A1 (en) | Novel processes and intermediates for the preparation of piperazine derivatives | |
RU95112573A (ru) | Способ получения 9-аминокамптотецина, промежуточные продукты, способ их получения и фармкомпозиция | |
CA2076886A1 (en) | Method for production of 2-amino-6-halogenopurine and synthesis intermediate therefor | |
DK0601191T3 (da) | Hidtil ukendt tetracyklisk forbindelse | |
DE3781879T2 (de) | Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
CA2258539A1 (en) | Ring-fused dihydropyranes, process for the preparation and use thereof | |
EG20562A (en) | Process for preparing glutaramide derivatives | |
JPS57192340A (en) | Isoprenylamine derivative | |
TW430658B (en) | A process for producing an acridine carboxamide via a tetrafluoroborate salt | |
AU7206898A (en) | Method for producing 1,3-di-substituted 2-nitroguanidines |