CN1406938A - 在制备他汀类的过程中的内酯化方法 - Google Patents
在制备他汀类的过程中的内酯化方法 Download PDFInfo
- Publication number
- CN1406938A CN1406938A CN02127086A CN02127086A CN1406938A CN 1406938 A CN1406938 A CN 1406938A CN 02127086 A CN02127086 A CN 02127086A CN 02127086 A CN02127086 A CN 02127086A CN 1406938 A CN1406938 A CN 1406938A
- Authority
- CN
- China
- Prior art keywords
- formula
- preparation
- compound according
- solvent
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0051796A KR100407758B1 (ko) | 2001-08-27 | 2001-08-27 | 스타틴의 제조에 있어서 락톤화 방법 |
KR0051796/2001 | 2001-08-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1406938A true CN1406938A (zh) | 2003-04-02 |
CN1193022C CN1193022C (zh) | 2005-03-16 |
Family
ID=19713589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021270864A Expired - Fee Related CN1193022C (zh) | 2001-08-27 | 2002-07-29 | 在制备他汀类的过程中的内酯化方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6649775B2 (zh) |
EP (1) | EP1288212B1 (zh) |
JP (1) | JP2003096071A (zh) |
KR (1) | KR100407758B1 (zh) |
CN (1) | CN1193022C (zh) |
AT (1) | ATE393151T1 (zh) |
DE (1) | DE60226203T2 (zh) |
WO (1) | WO2003018570A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011060742A1 (zh) * | 2009-11-20 | 2011-05-26 | 北大方正集团有限公司 | 制备他汀类化合物的内酯化方法 |
CN102875505A (zh) * | 2012-08-02 | 2013-01-16 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
CN103172603A (zh) * | 2011-12-22 | 2013-06-26 | 北大方正集团有限公司 | 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法 |
CN103172602A (zh) * | 2011-12-22 | 2013-06-26 | 北大方正集团有限公司 | 一种纯化洛伐他汀的方法 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI21234A (sl) * | 2001-05-18 | 2003-12-31 | Aurobindo Pharma Limited | Postopek laktonizacije za proizvodnjo izredno čistega simvastatina |
US6995277B2 (en) | 2003-02-11 | 2006-02-07 | Plus Chemicals, B.V. | Process for preparing simvastatin having controlled ranges of simvastatin dimer content |
KR20050111629A (ko) * | 2003-04-01 | 2005-11-25 | 플러스 케미칼스 비.브이. | 무정형 심바스타틴 칼슘 및 그의 제조방법 |
BRPI0418644A (pt) * | 2004-03-30 | 2007-05-29 | Lupin Ltd | processo para a preparação de um composto |
CN1993365A (zh) * | 2004-06-30 | 2007-07-04 | 纳幕尔杜邦公司 | 利用共沸蒸馏进行的醛糖内酯、醛糖二酸内酯和醛糖二酸双内酯的合成 |
JP2008515769A (ja) * | 2004-06-30 | 2008-05-15 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 共沸蒸留を用いた、アルドノラクトン、アルダロラクトン、およびアルダロジラクトンの合成 |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
SG155189A1 (en) * | 2004-08-06 | 2009-09-30 | Transform Pharmaceuticals Inc | Novel fenofibrate formulations and related methods of treatment |
NZ552389A (en) * | 2004-08-06 | 2009-05-31 | Transform Pharmaceuticals Inc | Statin pharmaceutical compositions and related methods of treatment |
JO2897B1 (en) | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
ATE552825T1 (de) | 2006-04-26 | 2012-04-15 | Rosemont Pharmaceuticals Ltd | Flüssige orale zusammensetzungen |
JP2009114121A (ja) * | 2007-11-06 | 2009-05-28 | Kaneka Corp | シンバスタチンの製造方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588820A (en) | 1984-06-11 | 1986-05-13 | Merck & Co., Inc. | Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one |
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
IN186880B (zh) * | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
ZA9810764B (en) * | 1998-04-22 | 1999-08-13 | Ranbaxy Lab Ltd | An improved process of lactonization in the preparation of statins. |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
JP2000106835A (ja) * | 1998-09-30 | 2000-04-18 | Gunze Ltd | 紅麹及びその製造法 |
PL346392A1 (en) * | 1999-06-29 | 2002-02-11 | Kaneka Corp | Process for selective lactonization |
-
2001
- 2001-08-27 KR KR10-2001-0051796A patent/KR100407758B1/ko not_active IP Right Cessation
-
2002
- 2002-07-06 WO PCT/KR2002/001281 patent/WO2003018570A1/en active Search and Examination
- 2002-07-10 EP EP02015509A patent/EP1288212B1/en not_active Expired - Lifetime
- 2002-07-10 AT AT02015509T patent/ATE393151T1/de not_active IP Right Cessation
- 2002-07-10 DE DE60226203T patent/DE60226203T2/de not_active Expired - Lifetime
- 2002-07-23 US US10/200,174 patent/US6649775B2/en not_active Expired - Fee Related
- 2002-07-29 CN CNB021270864A patent/CN1193022C/zh not_active Expired - Fee Related
- 2002-08-26 JP JP2002245931A patent/JP2003096071A/ja active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011060742A1 (zh) * | 2009-11-20 | 2011-05-26 | 北大方正集团有限公司 | 制备他汀类化合物的内酯化方法 |
US8779167B2 (en) | 2009-11-20 | 2014-07-15 | Peking University Founder Group Co., Ltd. | Method for preparing a statin compound by lactonization |
CN103172603A (zh) * | 2011-12-22 | 2013-06-26 | 北大方正集团有限公司 | 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法 |
CN103172602A (zh) * | 2011-12-22 | 2013-06-26 | 北大方正集团有限公司 | 一种纯化洛伐他汀的方法 |
CN103172603B (zh) * | 2011-12-22 | 2014-12-17 | 北大方正集团有限公司 | 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法 |
CN102875505A (zh) * | 2012-08-02 | 2013-01-16 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
CN102875505B (zh) * | 2012-08-02 | 2015-08-05 | 丽珠集团新北江制药股份有限公司 | 一种美伐他汀的提取精制工艺 |
Also Published As
Publication number | Publication date |
---|---|
ATE393151T1 (de) | 2008-05-15 |
US20030050482A1 (en) | 2003-03-13 |
KR20030018202A (ko) | 2003-03-06 |
DE60226203T2 (de) | 2009-05-14 |
DE60226203D1 (de) | 2008-06-05 |
US6649775B2 (en) | 2003-11-18 |
KR100407758B1 (ko) | 2003-12-01 |
JP2003096071A (ja) | 2003-04-03 |
WO2003018570A1 (en) | 2003-03-06 |
EP1288212A1 (en) | 2003-03-05 |
CN1193022C (zh) | 2005-03-16 |
EP1288212B1 (en) | 2008-04-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1193022C (zh) | 在制备他汀类的过程中的内酯化方法 | |
US6525205B2 (en) | Lactonization process | |
CN1443182A (zh) | 一种可降低二聚体杂质水平的提纯洛伐他汀和辛伐他汀的方法 | |
CN113943286B (zh) | 一种胆碱受体拮抗剂的制备方法 | |
CN1197854C (zh) | 他汀类化合物制备中的内酯化处理方法 | |
CN1476440A (zh) | 一种内酯化方法 | |
WO2018067805A1 (en) | Solid state forms of sotagliflozin | |
US6995277B2 (en) | Process for preparing simvastatin having controlled ranges of simvastatin dimer content | |
EP1673361B1 (en) | A method for the manufacture of lovastatin | |
BG107477A (bg) | Лактонизационен метод за получаване на симвастатин с висока чистота | |
JP2003528869A (ja) | シンバスタチンの製造方法 | |
JP2004520444A5 (zh) | ||
JPH0374384A (ja) | 3r‐(3‐カルボキシベンジル)‐6‐(5‐フルオロ‐2‐ベンゾチアゾリル)メトキシ‐4r‐クロマノールの光学分割方法 | |
CN1173488A (zh) | 制备辛伐他汀中关键的中间体 | |
CN1277826C (zh) | 辉伐他汀及其合成方法和以辉伐他汀为原料药的制剂 | |
KR19980035249A (ko) | 세팔로스포린 유도체의 에스테르 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: CJ CHEIL JEDANG CORP. Free format text: FORMER OWNER: CHEIL JEDANG CORP. Effective date: 20081024 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081024 Address after: Seoul, South Kerean Patentee after: CJ Corp. Address before: Seoul Patentee before: First sugar refining Corporation |
|
ASS | Succession or assignment of patent right |
Owner name: CJ HEALTHCARE CO., LTD. Free format text: FORMER OWNER: CJ CORP. Effective date: 20150114 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150114 Address after: Seoul, South Kerean Patentee after: CJ CHEILJEDANG CORPORATION Address before: Seoul, South Kerean Patentee before: CJ Corp. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050316 Termination date: 20150729 |
|
EXPY | Termination of patent right or utility model |