IN186880B - - Google Patents

Info

Publication number
IN186880B
IN186880B IN3102DE1997A IN186880B IN 186880 B IN186880 B IN 186880B IN 3102DE1997 A IN3102DE1997 A IN 3102DE1997A IN 186880 B IN186880 B IN 186880B
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Yatendra Kumar
Rajesh Kumar Thaper
S M Dileep Kumar
Jag Mohan Khanna
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Priority to IN3102DE1997 priority Critical patent/IN186880B/en
Priority to US09/064,285 priority patent/US5917058A/en
Publication of IN186880B publication Critical patent/IN186880B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IN3102DE1997 1997-10-28 1997-10-28 IN186880B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN3102DE1997 IN186880B (zh) 1997-10-28 1997-10-28
US09/064,285 US5917058A (en) 1997-10-28 1998-04-22 Process of lactonization in the preparation of statins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3102DE1997 IN186880B (zh) 1997-10-28 1997-10-28

Publications (1)

Publication Number Publication Date
IN186880B true IN186880B (zh) 2001-12-01

Family

ID=11092798

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3102DE1997 IN186880B (zh) 1997-10-28 1997-10-28

Country Status (2)

Country Link
US (1) US5917058A (zh)
IN (1) IN186880B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
DE01913139T1 (de) 2000-03-03 2005-03-31 Plus Chemical S.A. Ein verfahren zur reinigung von lovastatin und simvastatin mit verringertem gehalt an dimeren verunreinigungen
NL1017548C2 (nl) 2001-03-09 2002-09-10 Synthon Bv Een lactonisatie proces.
SI21234A (sl) * 2001-05-18 2003-12-31 Aurobindo Pharma Limited Postopek laktonizacije za proizvodnjo izredno čistega simvastatina
US6797831B2 (en) * 2001-05-18 2004-09-28 Aurobindo Pharma Limited Process for lactonization to produce simvastatin
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
KR100423892B1 (ko) * 2001-12-03 2004-03-22 씨제이 주식회사 스타틴의 제조에 있어서 새로운 락톤화 방법
KR100502833B1 (ko) * 2002-03-25 2005-07-25 보령제약 주식회사 심바스타틴 및 이의 중간체 화합물들의 개선된 제조방법
KR100502834B1 (ko) * 2002-03-25 2005-07-20 보령제약 주식회사 개선된 락톤화 반응에 의한 심바스타틴의 제조방법 및이의 정제방법
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
BRPI0418644A (pt) * 2004-03-30 2007-05-29 Lupin Ltd processo para a preparação de um composto
US20050239885A1 (en) * 2004-04-22 2005-10-27 Glenmark Pharmaceuticals Limited Processes for the preparation of simvastatin
CA2571379C (en) * 2004-09-08 2012-08-07 Jubilant Organosys Limited An improved process for lactonization in the preparation of statins
WO2006059346A2 (en) * 2004-12-01 2006-06-08 Morepen Laboratories Limited An improved process for lactonization to produce highly pure statins
WO2007020079A2 (en) * 2005-08-17 2007-02-22 Synthon B.V. Orally disintegratable simvastatin tablets
US20090048335A1 (en) * 2007-08-17 2009-02-19 Venkata Naga Mandava Process for preparing simvastatin
ES2614804T3 (es) 2009-09-30 2017-06-02 Codexis, Inc. Acilación mejorada mediada por LovD aciltransferasa

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof

Also Published As

Publication number Publication date
US5917058A (en) 1999-06-29

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