HUP9901526A2 - Atorvastatin szintézis, közbenső termékei és eljárás ezek előállítására - Google Patents

Atorvastatin szintézis, közbenső termékei és eljárás ezek előállítására

Info

Publication number
HUP9901526A2
HUP9901526A2 HU9901526A HUP9901526A HUP9901526A2 HU P9901526 A2 HUP9901526 A2 HU P9901526A2 HU 9901526 A HU9901526 A HU 9901526A HU P9901526 A HUP9901526 A HU P9901526A HU P9901526 A2 HUP9901526 A2 HU P9901526A2
Authority
HU
Hungary
Prior art keywords
intermediates
salts
producing
atorvastatin
formula
Prior art date
Application number
HU9901526A
Other languages
English (en)
Inventor
József Barkóczy
Zoltán Greff
Nagy Péter Kótay
Gyula Simig
Ferenc Bartha
Kálmán Nagy
Donáth Györgyi Vereczkeyné
László Balázs
Imre Domán
Zoltán Rátkai
Péter Seres
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9901526A priority Critical patent/HU227840B1/hu
Publication of HU9901526D0 publication Critical patent/HU9901526D0/hu
Priority to EP00927612A priority patent/EP1178980A1/en
Priority to JP2000617201A priority patent/JP2002544207A/ja
Priority to CA002373077A priority patent/CA2373077A1/en
Priority to CN00807159A priority patent/CN1349522A/zh
Priority to PCT/HU2000/000042 priority patent/WO2000068221A1/en
Priority to PL00351145A priority patent/PL351145A1/xx
Priority to KR1020017014104A priority patent/KR20020033617A/ko
Priority to SK1584-2001A priority patent/SK15842001A3/sk
Priority to CZ20013965A priority patent/CZ20013965A3/cs
Priority to RU2001133066/04A priority patent/RU2001133066A/ru
Priority to AU46002/00A priority patent/AU4600200A/en
Publication of HUP9901526A2 publication Critical patent/HUP9901526A2/hu
Priority to HR20010846A priority patent/HRP20010846A2/hr
Priority to HK02105736.6A priority patent/HK1046271A1/zh
Publication of HU227840B1 publication Critical patent/HU227840B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány az (I) képletű (4R-cisz)-(1,1- dimetil-etil)-6-(2-amino-etil)-2,2-dimetil-1,3-dioxán-4-acetát szerves savakkal képezett sóiravonatkozik. A találmány szerinti új sók stabil, átkristályosítássalkönnyen tisztítható új vegyületek. A találmány szerinti új sók értékesgyógyászati közbenső termékek, amelyek pl. az atorvastatin nemzetköziszabadnevű hipolipidémiás gyógyászati hatóanyag előállításánálalkalmazhatók. Találmányunk továbbá az (I) képletű vegyület sóinak újelőállítására vonatkozik. Ó
HU9901526A 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them HU227840B1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them
AU46002/00A AU4600200A (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
PL00351145A PL351145A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
SK1584-2001A SK15842001A3 (sk) 1999-05-06 2000-05-05 Soli 2,2-dimetyl-1,3-dioxánových medziproduktov a spôsob ich prípravy
CA002373077A CA2373077A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
CN00807159A CN1349522A (zh) 1999-05-06 2000-05-05 2,2－二甲基－1,3－二氧杂环己烷中间体的盐及其制备方法
PCT/HU2000/000042 WO2000068221A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
EP00927612A EP1178980A1 (en) 1999-05-06 2000-05-05 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
KR1020017014104A KR20020033617A (ko) 1999-05-06 2000-05-05 2,2-디메틸-1,3-디옥산 중간체의 염 및 그것의 제조방법
JP2000617201A JP2002544207A (ja) 1999-05-06 2000-05-05 ２，２−ジメチル−１，３−ジオキサン中間体の塩及びその製法
CZ20013965A CZ20013965A3 (cs) 1999-05-06 2000-05-05 Soli 2,2-dimethyl-1,3-dioxanových meziproduktů a způsob jejich přípravy
RU2001133066/04A RU2001133066A (ru) 1999-05-06 2000-05-05 Соли полупродуктов 2,2-диметил-1,3-диоксана и способ их получения
HR20010846A HRP20010846A2 (en) 1999-05-06 2001-11-16 Salts of 2,2-dimethyl-1,3-dioxane intermediates and process for the preparation thereof
HK02105736.6A HK1046271A1 (zh) 1999-05-06 2002-08-06 2，2-二甲基-1，3-二氧雜環乙烷半成品的鹽及有關製劑加工

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them

Publications (3)

Publication Number Publication Date
HU9901526D0 HU9901526D0 (en) 1999-07-28
HUP9901526A2 true HUP9901526A2 (hu) 2001-04-28
HU227840B1 HU227840B1 (en) 2012-05-02

Family

ID=89998261

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901526A HU227840B1 (en) 1999-05-06 1999-05-06 Intermediates of atorvastatin synthesis and process for producing them

Country Status (14)

Country Link
EP (1) EP1178980A1 (hu)
JP (1) JP2002544207A (hu)
KR (1) KR20020033617A (hu)
CN (1) CN1349522A (hu)
AU (1) AU4600200A (hu)
CA (1) CA2373077A1 (hu)
CZ (1) CZ20013965A3 (hu)
HK (1) HK1046271A1 (hu)
HR (1) HRP20010846A2 (hu)
HU (1) HU227840B1 (hu)
PL (1) PL351145A1 (hu)
RU (1) RU2001133066A (hu)
SK (1) SK15842001A3 (hu)
WO (1) WO2000068221A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
WO2003004456A1 (en) 2001-07-06 2003-01-16 Teva Pharmaceutical Industries Ltd. Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
EP1323717A1 (en) 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
EP1375493A1 (en) 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
IE20060197A1 (en) 2005-03-14 2006-10-18 Pfizer Science & Tech Ltd Preparation of an atorvastatin intermediate
WO2007034909A1 (ja) * 2005-09-22 2007-03-29 Kaneka Corporation （３ｒ，５ｒ）－７－アミノ－３，５－ジヒドロキシヘプタン酸誘導体の製造法
SI2614057T1 (sl) 2010-09-09 2016-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Soli estrov 7-amino-3,5-dihidroksi heptanojske kisline
WO2017022846A1 (ja) 2015-08-05 2017-02-09 株式会社エーピーアイ コーポレーション ピタバスタチンカルシウムの製造方法
CN108191813B (zh) * 2017-12-20 2020-01-17 帕潘纳(北京)科技有限公司 一种缩酮的制备方法
CN109232353A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种阿托伐他汀钙缩合物的制备方法
CN109232354A (zh) * 2018-10-09 2019-01-18 河南师范大学 一种高纯度阿托伐他汀钙原料药的制备方法
CN110940764B (zh) * 2019-12-31 2022-06-28 湖南九典制药股份有限公司 一种他汀类药物光学异构体的分离方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
US5103024A (en) * 1990-10-17 1992-04-07 Warner-Lambert Company Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
JP3652394B2 (ja) * 1995-01-27 2005-05-25 高砂香料工業株式会社 Ｎ−置換−７−アミノ−５−ヒドロキシ−３−オキソヘプタン酸誘導体およびその製造法
TR199900191T2 (xx) * 1996-07-29 1999-04-21 Warner-Lambert Company (S)-3,4-Dihidroksibutirik asitin korumal� esterlerinin sentezi i�in geli�tirilmi� proses.
HUP0103659A3 (en) * 1998-04-30 2003-01-28 Kaneka Corp Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives

Also Published As

Publication number Publication date
AU4600200A (en) 2000-11-21
CN1349522A (zh) 2002-05-15
WO2000068221A1 (en) 2000-11-16
CZ20013965A3 (cs) 2002-04-17
PL351145A1 (en) 2003-03-24
JP2002544207A (ja) 2002-12-24
SK15842001A3 (sk) 2002-04-04
HRP20010846A2 (en) 2003-02-28
CA2373077A1 (en) 2000-11-16
EP1178980A1 (en) 2002-02-13
HU9901526D0 (en) 1999-07-28
HU227840B1 (en) 2012-05-02
KR20020033617A (ko) 2002-05-07
HK1046271A1 (zh) 2003-01-03
RU2001133066A (ru) 2004-02-27

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: EGIS GYOGYSZERGYAR NYILVANOSAN MUEKOEDOE RESZV, HU

Free format text: FORMER OWNER(S): EGIS GYOGYSZERGYAR RT., HU

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished
MM4A Lapse of definitive patent protection due to non-payment of fees