ATE288891T1 - Verfahren zur herstellung von amid-derivaten und ihren zwischenverbindungen - Google Patents
Verfahren zur herstellung von amid-derivaten und ihren zwischenverbindungenInfo
- Publication number
- ATE288891T1 ATE288891T1 AT96931296T AT96931296T ATE288891T1 AT E288891 T1 ATE288891 T1 AT E288891T1 AT 96931296 T AT96931296 T AT 96931296T AT 96931296 T AT96931296 T AT 96931296T AT E288891 T1 ATE288891 T1 AT E288891T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- compound
- äxvü
- äxviü
- intermediate compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 150000001408 amides Chemical class 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 3
- 108010010369 HIV Protease Proteins 0.000 abstract 1
- 229940039231 contrast media Drugs 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/04—Seven-membered rings not condensed with other rings
- C07D321/06—1,3-Dioxepines; Hydrogenated 1,3-dioxepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24818395 | 1995-09-26 | ||
| PCT/JP1996/002756 WO1997011937A1 (en) | 1995-09-26 | 1996-09-24 | Process for producing amide derivatives and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288891T1 true ATE288891T1 (de) | 2005-02-15 |
Family
ID=17174443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96931296T ATE288891T1 (de) | 1995-09-26 | 1996-09-24 | Verfahren zur herstellung von amid-derivaten und ihren zwischenverbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US6133461A (de) |
| EP (1) | EP0983999B8 (de) |
| JP (1) | JP3566968B2 (de) |
| AT (1) | ATE288891T1 (de) |
| AU (1) | AU717637B2 (de) |
| DE (1) | DE69634345T2 (de) |
| ES (1) | ES2233976T3 (de) |
| PT (1) | PT983999E (de) |
| WO (1) | WO1997011937A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962725A (en) | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| UA67727C2 (uk) * | 1996-09-05 | 2004-07-15 | Агурон Фармасевтікелс, Інк. | Проміжні сполуки для одержання інгібіторів віл-протеази і способи одержання інгібіторів віл-протеази |
| DE19730602A1 (de) * | 1997-07-17 | 1999-01-21 | Clariant Gmbh | 3-Acetoxy-2-methylbenzoesäurechlorid und ein Verfahren zu seiner Herstellung |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| IN188157B (de) | 1998-01-16 | 2002-08-24 | Japan Tobacco Inc | |
| US6403799B1 (en) | 1999-10-21 | 2002-06-11 | Agouron Pharmaceuticals, Inc. | Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors |
| SG145573A1 (en) | 2003-05-08 | 2008-09-29 | Pfizer | Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same |
| JPWO2005040099A1 (ja) * | 2003-10-23 | 2007-03-08 | 小野薬品工業株式会社 | ３−置換−（２ｒ，３ｒ）−２−保護されたアミノ−３−ヒドロキシプロピオン酸誘導体の製造方法およびその中間体 |
| CN112409370B (zh) * | 2020-12-10 | 2021-12-24 | 四川新迪医药化工有限公司 | 环氧侧链中间体的制备方法及环氧侧链中间体、钆布醇 |
| CN115724849B (zh) * | 2022-11-28 | 2025-01-24 | 安庆朗坤药业有限公司 | 一种4,4-二甲基-3,5,8-三氧杂双环[5.1.0]辛烷的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110101A (en) * | 1977-04-06 | 1978-08-29 | Velsicol Chemical Corporation | Dioxepane substituted amides |
| US4341756A (en) * | 1980-01-31 | 1982-07-27 | The Regents Of The University Of California | Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media |
| JPS56127373A (en) * | 1980-01-31 | 1981-10-06 | Univ California | Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent |
| MX9308016A (es) * | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
-
1996
- 1996-09-24 US US09/043,668 patent/US6133461A/en not_active Expired - Fee Related
- 1996-09-24 DE DE69634345T patent/DE69634345T2/de not_active Expired - Fee Related
- 1996-09-24 JP JP51328297A patent/JP3566968B2/ja not_active Expired - Fee Related
- 1996-09-24 EP EP96931296A patent/EP0983999B8/de not_active Expired - Lifetime
- 1996-09-24 ES ES96931296T patent/ES2233976T3/es not_active Expired - Lifetime
- 1996-09-24 AT AT96931296T patent/ATE288891T1/de not_active IP Right Cessation
- 1996-09-24 AU AU70020/96A patent/AU717637B2/en not_active Expired
- 1996-09-24 WO PCT/JP1996/002756 patent/WO1997011937A1/ja not_active Ceased
- 1996-09-24 PT PT96931296T patent/PT983999E/pt unknown
-
2000
- 2000-05-30 US US09/580,831 patent/US6252085B1/en not_active Expired - Fee Related
-
2001
- 2001-04-17 US US09/835,487 patent/US6333416B2/en not_active Expired - Fee Related
- 2001-10-26 US US09/983,978 patent/US6476232B2/en not_active Expired - Fee Related
-
2002
- 2002-09-13 US US10/242,392 patent/US6596903B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6476232B2 (en) | 2002-11-05 |
| WO1997011937A1 (en) | 1997-04-03 |
| US6596903B2 (en) | 2003-07-22 |
| JP3566968B2 (ja) | 2004-09-15 |
| US6333416B2 (en) | 2001-12-25 |
| EP0983999A1 (de) | 2000-03-08 |
| AU717637B2 (en) | 2000-03-30 |
| US20020049337A1 (en) | 2002-04-25 |
| ES2233976T3 (es) | 2005-06-16 |
| DE69634345D1 (de) | 2005-03-17 |
| DE69634345T2 (de) | 2006-03-02 |
| US6252085B1 (en) | 2001-06-26 |
| US20030040633A1 (en) | 2003-02-27 |
| EP0983999B1 (de) | 2005-02-09 |
| EP0983999B8 (de) | 2005-06-08 |
| EP0983999A4 (de) | 2002-09-11 |
| AU7002096A (en) | 1997-04-17 |
| PT983999E (pt) | 2005-05-31 |
| US6133461A (en) | 2000-10-17 |
| US20010021782A1 (en) | 2001-09-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0983999 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |