ATE264849T1 - Ein verbessertes verfahren zur herstellung von statinen - Google Patents

Ein verbessertes verfahren zur herstellung von statinen

Info

Publication number
ATE264849T1
ATE264849T1 AT98123252T AT98123252T ATE264849T1 AT E264849 T1 ATE264849 T1 AT E264849T1 AT 98123252 T AT98123252 T AT 98123252T AT 98123252 T AT98123252 T AT 98123252T AT E264849 T1 ATE264849 T1 AT E264849T1
Authority
AT
Austria
Prior art keywords
statins
solvent
lactonization
reaction
improved process
Prior art date
Application number
AT98123252T
Other languages
English (en)
Inventor
Yatendra Kumar
Rajest Kumar Thaper
S M Dileep Kumar
Jag Mohan Khanna
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/064,285 external-priority patent/US5917058A/en
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of ATE264849T1 publication Critical patent/ATE264849T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Glass Compositions (AREA)
AT98123252T 1998-04-22 1998-12-07 Ein verbessertes verfahren zur herstellung von statinen ATE264849T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/064,285 US5917058A (en) 1997-10-28 1998-04-22 Process of lactonization in the preparation of statins

Publications (1)

Publication Number Publication Date
ATE264849T1 true ATE264849T1 (de) 2004-05-15

Family

ID=22054869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98123252T ATE264849T1 (de) 1998-04-22 1998-12-07 Ein verbessertes verfahren zur herstellung von statinen

Country Status (10)

Country Link
EP (1) EP0955297B9 (de)
AT (1) ATE264849T1 (de)
DE (1) DE69823333T2 (de)
DK (1) DK0955297T3 (de)
ES (1) ES2217485T3 (de)
HK (1) HK1023572A1 (de)
HU (1) HUP9802936A3 (de)
PT (1) PT955297E (de)
RU (1) RU2214407C2 (de)
ZA (1) ZA9810764B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2127500A (en) 1999-11-11 2001-06-06 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
SK702003A3 (en) * 2001-05-18 2003-12-02 Aurobindo Pharma Ltd A process for lactonization to produce simvastatin
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4916239A (en) * 1988-07-19 1990-04-10 Merck & Co., Inc. Process for the lactonization of mevinic acids and analogs thereof
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof

Also Published As

Publication number Publication date
DE69823333T2 (de) 2005-04-07
ZA9810764B (en) 1999-08-13
HUP9802936A3 (en) 2000-04-28
EP0955297B1 (de) 2004-04-21
EP0955297B9 (de) 2004-12-15
PT955297E (pt) 2004-08-31
HU9802936D0 (en) 1999-02-01
ES2217485T3 (es) 2004-11-01
DK0955297T3 (da) 2004-08-16
DE69823333D1 (de) 2004-05-27
RU2214407C2 (ru) 2003-10-20
HK1023572A1 (en) 2000-09-15
HUP9802936A2 (hu) 1999-11-29
EP0955297A1 (de) 1999-11-10

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