ATE264849T1 - Ein verbessertes verfahren zur herstellung von statinen - Google Patents
Ein verbessertes verfahren zur herstellung von statinenInfo
- Publication number
- ATE264849T1 ATE264849T1 AT98123252T AT98123252T ATE264849T1 AT E264849 T1 ATE264849 T1 AT E264849T1 AT 98123252 T AT98123252 T AT 98123252T AT 98123252 T AT98123252 T AT 98123252T AT E264849 T1 ATE264849 T1 AT E264849T1
- Authority
- AT
- Austria
- Prior art keywords
- statins
- solvent
- lactonization
- reaction
- improved process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Glass Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/064,285 US5917058A (en) | 1997-10-28 | 1998-04-22 | Process of lactonization in the preparation of statins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE264849T1 true ATE264849T1 (de) | 2004-05-15 |
Family
ID=22054869
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98123252T ATE264849T1 (de) | 1998-04-22 | 1998-12-07 | Ein verbessertes verfahren zur herstellung von statinen |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0955297B9 (de) |
AT (1) | ATE264849T1 (de) |
DE (1) | DE69823333T2 (de) |
DK (1) | DK0955297T3 (de) |
ES (1) | ES2217485T3 (de) |
HK (1) | HK1023572A1 (de) |
HU (1) | HUP9802936A3 (de) |
PT (1) | PT955297E (de) |
RU (1) | RU2214407C2 (de) |
ZA (1) | ZA9810764B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2127500A (en) | 1999-11-11 | 2001-06-06 | Biocon India Limited | Process for manufacturing simvastatin and the novel intermediates |
US6573385B1 (en) | 1999-11-11 | 2003-06-03 | Biocon India Limited | Process for manufacturing simvastatin and novel intermediates thereof |
SK702003A3 (en) * | 2001-05-18 | 2003-12-02 | Aurobindo Pharma Ltd | A process for lactonization to produce simvastatin |
KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
US6603022B1 (en) | 2002-05-10 | 2003-08-05 | Biocon India Limited | Process for manufacturing Simvastatin and novel intermediates thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4820850A (en) * | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
US4916239A (en) * | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
US5393893A (en) * | 1993-11-08 | 1995-02-28 | Apotex, Inc. | Process for producing simvastatin and analogs thereof |
-
1998
- 1998-11-25 ZA ZA9810764A patent/ZA9810764B/xx unknown
- 1998-12-07 PT PT98123252T patent/PT955297E/pt unknown
- 1998-12-07 AT AT98123252T patent/ATE264849T1/de not_active IP Right Cessation
- 1998-12-07 EP EP98123252A patent/EP0955297B9/de not_active Expired - Lifetime
- 1998-12-07 ES ES98123252T patent/ES2217485T3/es not_active Expired - Lifetime
- 1998-12-07 DE DE69823333T patent/DE69823333T2/de not_active Expired - Fee Related
- 1998-12-07 DK DK98123252T patent/DK0955297T3/da active
- 1998-12-09 RU RU98122366/04A patent/RU2214407C2/ru not_active IP Right Cessation
- 1998-12-16 HU HU9802936A patent/HUP9802936A3/hu unknown
-
2000
- 2000-05-08 HK HK00102749A patent/HK1023572A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69823333T2 (de) | 2005-04-07 |
ZA9810764B (en) | 1999-08-13 |
HUP9802936A3 (en) | 2000-04-28 |
EP0955297B1 (de) | 2004-04-21 |
EP0955297B9 (de) | 2004-12-15 |
PT955297E (pt) | 2004-08-31 |
HU9802936D0 (en) | 1999-02-01 |
ES2217485T3 (es) | 2004-11-01 |
DK0955297T3 (da) | 2004-08-16 |
DE69823333D1 (de) | 2004-05-27 |
RU2214407C2 (ru) | 2003-10-20 |
HK1023572A1 (en) | 2000-09-15 |
HUP9802936A2 (hu) | 1999-11-29 |
EP0955297A1 (de) | 1999-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0955297 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |