DE69909508D1 - Verfahren zur herstellung von simvastatin und deren analogen - Google Patents

Verfahren zur herstellung von simvastatin und deren analogen

Info

Publication number
DE69909508D1
DE69909508D1 DE69909508T DE69909508T DE69909508D1 DE 69909508 D1 DE69909508 D1 DE 69909508D1 DE 69909508 T DE69909508 T DE 69909508T DE 69909508 T DE69909508 T DE 69909508T DE 69909508 D1 DE69909508 D1 DE 69909508D1
Authority
DE
Germany
Prior art keywords
simvastatin
analogs
derivatives
fermentation
producing simvastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69909508T
Other languages
English (en)
Other versions
DE69909508T2 (de
Inventor
Marco Zlicar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Application granted granted Critical
Publication of DE69909508D1 publication Critical patent/DE69909508D1/de
Publication of DE69909508T2 publication Critical patent/DE69909508T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69909508T 1998-12-02 1999-12-01 Verfahren zur herstellung von simvastatin und deren analogen Expired - Fee Related DE69909508T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI9800300 1998-12-02
SI9800300A SI20116A (sl) 1998-12-02 1998-12-02 Nov postopek za pripravo simvastatina in njegovih analogov
PCT/IB1999/001912 WO2000032585A1 (en) 1998-12-02 1999-12-01 Process for the preparation of simvastatin and analogs thereof

Publications (2)

Publication Number Publication Date
DE69909508D1 true DE69909508D1 (de) 2003-08-14
DE69909508T2 DE69909508T2 (de) 2004-02-19

Family

ID=20432366

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69909508T Expired - Fee Related DE69909508T2 (de) 1998-12-02 1999-12-01 Verfahren zur herstellung von simvastatin und deren analogen

Country Status (8)

Country Link
US (1) US6384238B1 (de)
EP (1) EP1135380B1 (de)
JP (1) JP2002531447A (de)
AT (1) ATE244710T1 (de)
AU (1) AU1510800A (de)
DE (1) DE69909508T2 (de)
SI (1) SI20116A (de)
WO (1) WO2000032585A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361833B1 (ko) * 2000-06-20 2002-11-22 주식회사 엘지생명과학 심바스타틴의 제조방법
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
SK285772B6 (sk) * 2002-11-20 2007-08-02 Zentiva, A. S. Spôsob prípravy simvastatínu
CA2543348A1 (en) * 2003-10-21 2005-05-06 Diversa Corporation Methods for making simvastatin and intermediates
WO2005077928A1 (en) * 2004-02-12 2005-08-25 Jubilant Organosys Limited Improved process for producing simvastatin
CN1754870A (zh) * 2004-09-30 2006-04-05 淮北市辉克药业有限公司 辛伐他汀的制备方法
US20080102081A1 (en) * 2006-08-08 2008-05-01 ALEXIS Brian Preparations and applications for treatment of high cholesterol levels
US20110059493A1 (en) * 2007-08-27 2011-03-10 Brian Morgan Methods for Making Simvastatin and Intermediates
US8236786B2 (en) 2008-08-07 2012-08-07 Pulmagen Therapeutics (Inflammation) Limited Respiratory disease treatment
EA019441B1 (ru) 2008-12-30 2014-03-31 Палмаджен Терепьютикс (Инфлеммейшн) Лимитед Сульфонамиды, предназначенные для лечения респираторных нарушений
WO2010150014A1 (en) 2009-06-24 2010-12-29 Pulmagen Therapeutics (Inflammation) Limited 5r- 5 -deuterated glitazones for respiratory disease treatment
WO2011098746A1 (en) 2010-02-09 2011-08-18 Pulmagen Therapeutics (Inflammation) Limited Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
GB201002224D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
GB201002243D0 (en) 2010-02-10 2010-03-31 Argenta Therapeutics Ltd Respiratory disease treatment
CA2944989A1 (en) 2013-04-08 2014-10-16 Cytodyn Inc. Felinized antibodies and methods of treating retroviral infections in felines
EP3611155A1 (de) 2018-08-16 2020-02-19 Evonik Operations GmbH Herstellung von (meth)acrylsäureestern

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4582915A (en) 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
US4845237A (en) 1987-04-15 1989-07-04 Merck & Co., Inc. Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US5159104A (en) 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
CA2185961A1 (en) 1996-09-19 1998-03-20 K.S. Keshava Murthy Process for producing simvastatin
SI9800057A (sl) 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov

Also Published As

Publication number Publication date
DE69909508T2 (de) 2004-02-19
EP1135380A1 (de) 2001-09-26
JP2002531447A (ja) 2002-09-24
ATE244710T1 (de) 2003-07-15
AU1510800A (en) 2000-06-19
US6384238B1 (en) 2002-05-07
SI20116A (sl) 2000-06-30
EP1135380B1 (de) 2003-07-09
WO2000032585A1 (en) 2000-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee