ATE284396T1 - Verfahren zur bereitstellung von hochreinen hmg- coa reductase hemmer - Google Patents

Verfahren zur bereitstellung von hochreinen hmg- coa reductase hemmer

Info

Publication number
ATE284396T1
ATE284396T1 AT99941797T AT99941797T ATE284396T1 AT E284396 T1 ATE284396 T1 AT E284396T1 AT 99941797 T AT99941797 T AT 99941797T AT 99941797 T AT99941797 T AT 99941797T AT E284396 T1 ATE284396 T1 AT E284396T1
Authority
AT
Austria
Prior art keywords
coa reductase
reductase inhibitors
hmg
purity
chemical synthesis
Prior art date
Application number
AT99941797T
Other languages
English (en)
Inventor
Rok Grahek
Dusan Milivojevic
Andrej Bastarda
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Application granted granted Critical
Publication of ATE284396T1 publication Critical patent/ATE284396T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/422—Displacement mode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
AT99941797T 1998-09-18 1999-09-17 Verfahren zur bereitstellung von hochreinen hmg- coa reductase hemmer ATE284396T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800241A SI20072A (sl) 1998-09-18 1998-09-18 Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
PCT/IB1999/001553 WO2000017182A1 (en) 1998-09-18 1999-09-17 PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY

Publications (1)

Publication Number Publication Date
ATE284396T1 true ATE284396T1 (de) 2004-12-15

Family

ID=20432332

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941797T ATE284396T1 (de) 1998-09-18 1999-09-17 Verfahren zur bereitstellung von hochreinen hmg- coa reductase hemmer

Country Status (22)

Country Link
US (1) US6695969B1 (de)
EP (1) EP1114040B1 (de)
JP (1) JP3795755B2 (de)
KR (1) KR100607608B1 (de)
CN (1) CN1186335C (de)
AT (1) ATE284396T1 (de)
AU (1) AU766630B2 (de)
BG (1) BG64676B1 (de)
CA (1) CA2343645A1 (de)
DE (1) DE69922519T2 (de)
HR (1) HRP20010045B1 (de)
HU (1) HUP0102997A2 (de)
IL (2) IL142056A0 (de)
IS (1) IS2149B (de)
NZ (1) NZ509582A (de)
PL (1) PL200336B1 (de)
RO (1) RO121116B1 (de)
RS (1) RS49996B (de)
RU (1) RU2235098C2 (de)
SI (1) SI20072A (de)
SK (1) SK285868B6 (de)
WO (1) WO2000017182A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
ATE342717T1 (de) * 1999-11-30 2006-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
US7001919B2 (en) * 1999-12-14 2006-02-21 Teva Gyogyszergyar Reszvenytarsasag Forms of pravastatin sodium
US6521762B2 (en) * 2000-03-03 2003-02-18 BIOGAL Gyógyszergyar RT. Process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
PL361230A1 (en) * 2000-10-05 2004-10-04 Biogal Gyogyszergyar Rt. Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US6936731B2 (en) 2000-10-05 2005-08-30 TEVA Gyógyszergyár Részvénytársaság Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
KR100435078B1 (ko) * 2002-02-08 2004-06-09 종근당바이오 주식회사 심바스타틴의 정제방법
WO2004087935A2 (en) * 2003-04-01 2004-10-14 Ranbaxy Laboratories Limited Fermentation process for the preparation of pravastatin
US6978908B2 (en) * 2003-09-15 2005-12-27 Gerber Products Company Drinking vessel with adjustable handles
CA2546377A1 (en) 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
KR100881103B1 (ko) * 2004-09-28 2009-02-02 테바 파마슈티컬 인더스트리즈 리미티드 실질적으로 불순물을 함유하지 않는 아토르바스타틴 칼슘의형태를 제조하는 방법
CN102043030A (zh) * 2009-10-22 2011-05-04 北京万全阳光医学技术有限公司 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法
CN102621238A (zh) * 2011-02-01 2012-08-01 北京北大维信生物科技有限公司 一种测定HMG-CoA还原酶抑制剂浓度的方法
CN105985244A (zh) * 2015-02-04 2016-10-05 北京北大维信生物科技有限公司 化合物、其分离方法、合成方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
IT1232311B (it) * 1989-09-04 1992-01-28 Sclavo Spa Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
US5202029A (en) * 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
AU661996B2 (en) * 1991-03-14 1995-08-17 Kabushiki Kaisha Ace Denken Stock control system
US5420024A (en) * 1993-05-11 1995-05-30 Merck & Co., Inc. Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5427686A (en) * 1994-04-05 1995-06-27 Sri International Process for separating material from mixture using displacement chromatography
EP0877089A1 (de) * 1997-05-07 1998-11-11 Gist-Brocades B.V. Verfahren zur Herstellung eines Inhibitors der Hmg-Coa Reduktase

Also Published As

Publication number Publication date
SK20022000A3 (sk) 2001-08-06
IL142056A (en) 2006-08-01
KR100607608B1 (ko) 2006-08-02
HUP0102997A2 (hu) 2001-12-28
JP2002526486A (ja) 2002-08-20
PL200336B1 (pl) 2008-12-31
CA2343645A1 (en) 2000-03-30
IS5886A (is) 2001-03-12
RS49996B (sr) 2008-09-29
AU766630B2 (en) 2003-10-23
SI20072A (sl) 2000-04-30
BG105348A (en) 2001-11-30
EP1114040B1 (de) 2004-12-08
AU5528499A (en) 2000-04-10
CN1318063A (zh) 2001-10-17
HRP20010045B1 (en) 2005-08-31
CN1186335C (zh) 2005-01-26
KR20010099584A (ko) 2001-11-09
YU81800A (sh) 2003-02-28
RU2235098C2 (ru) 2004-08-27
US6695969B1 (en) 2004-02-24
PL345883A1 (en) 2002-01-14
HRP20010045A2 (en) 2001-12-31
IL142056A0 (en) 2002-03-10
IS2149B (is) 2006-10-13
SK285868B6 (sk) 2007-10-04
NZ509582A (en) 2003-10-31
JP3795755B2 (ja) 2006-07-12
EP1114040A1 (de) 2001-07-11
DE69922519T2 (de) 2005-12-08
DE69922519D1 (de) 2005-01-13
BG64676B1 (bg) 2005-11-30
WO2000017182A1 (en) 2000-03-30
RO121116B1 (ro) 2006-12-29

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