YU81800A - POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆE - Google Patents
POSTUPAK ZA DOBIJANJE INHIBITORA HMG-CoA REDUKTAZE VISOKE ČISTOĆEInfo
- Publication number
- YU81800A YU81800A YU81800A YU81800A YU81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A YU 81800 A YU81800 A YU 81800A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- coa reductase
- reductase inhibitors
- hmg
- purity
- chemical synthesis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/422—Displacement mode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin i njihovi derivati i analozi su poznati kao inhibitori HMG-CoA reduktaze i upotrebljavaju se kao antihiperholesterolemijski agensi. Najveci deo njih se proizvodi fermentacijom, upotrebom mikroorganizama razlicitih vrsta, odredjenih kao vrste koje pripadaju Aspergillus, Monascus, Nocardia, Amicolatopsis, Mucor ili Penicillium genus, neki se dobijaju tretmanom proizvoda fermentacije koriscenjem metoda hemijske sinteze ili su proizvodi totalne hemijske sinteze. Cistoca aktivnog sastojka je vazan faktor u proizvodnji bezbednog i delotvornog farmaceutskog preparata narocito, ukoliko se farmaceutski proizvod mora koristiti tokom lecenja ili prevencije visokog plazmatskog holesterola, zasnovanih na duzem vremenskom periodu. Akumulacija necistoca iz farmaceutskih preparata nize cistoce moze prouzrokovati brojne sporedne efekte u toku lecenja. Ovaj pronalazak se odnosi na novi industrijski postupak za izolovanje inhibitora HMG-CoA reduktaze upotrebom takozvane, hromatografije istiskivanjem. Upotreba pronalaska omogucuje dobijanje inhibitora HMG-CoA reduktaze visoke cistoce, u visokim prinosima, sa niskim troskovima proizvodnje i pogodnim ekoloskim balansom.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9800241A SI20072A (sl) | 1998-09-18 | 1998-09-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
Publications (2)
Publication Number | Publication Date |
---|---|
YU81800A true YU81800A (sh) | 2003-02-28 |
RS49996B RS49996B (sr) | 2008-09-29 |
Family
ID=20432332
Country Status (22)
Country | Link |
---|---|
US (1) | US6695969B1 (sh) |
EP (1) | EP1114040B1 (sh) |
JP (1) | JP3795755B2 (sh) |
KR (1) | KR100607608B1 (sh) |
CN (1) | CN1186335C (sh) |
AT (1) | ATE284396T1 (sh) |
AU (1) | AU766630B2 (sh) |
BG (1) | BG64676B1 (sh) |
CA (1) | CA2343645A1 (sh) |
DE (1) | DE69922519T2 (sh) |
HR (1) | HRP20010045B1 (sh) |
HU (1) | HUP0102997A2 (sh) |
IL (2) | IL142056A0 (sh) |
IS (1) | IS2149B (sh) |
NZ (1) | NZ509582A (sh) |
PL (1) | PL200336B1 (sh) |
RO (1) | RO121116B1 (sh) |
RS (1) | RS49996B (sh) |
RU (1) | RU2235098C2 (sh) |
SI (1) | SI20072A (sh) |
SK (1) | SK285868B6 (sh) |
WO (1) | WO2000017182A1 (sh) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
HUP9902352A1 (hu) * | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
RU2002114072A (ru) * | 1999-11-30 | 2004-07-20 | Биогал Джиоджисзерджиар РТ (HU) | Способ выделения соединений статина из ферментационного бульона |
CA2394200C (en) * | 1999-12-14 | 2006-10-03 | Biogal Gyogyszergyar Rt. | Novel forms of pravastatin sodium |
JP2003525935A (ja) | 2000-03-03 | 2003-09-02 | ビオガル ジョジセルジャール アール テー. | 低下したレベルの二量体不純物を伴うロバスタチン及びシンバスタチンの精製方法 |
US6936731B2 (en) | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
CZ20031166A3 (cs) * | 2000-10-05 | 2004-04-14 | Biogal Gyogyszergyar Rt | Sodná sůl pravastatinu, která v podstatě neobsahuje pravastatin lakton a epi-pravastatin a kompozice na její bázi |
US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
KR100407758B1 (ko) * | 2001-08-27 | 2003-12-01 | 씨제이 주식회사 | 스타틴의 제조에 있어서 락톤화 방법 |
JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
KR100435078B1 (ko) * | 2002-02-08 | 2004-06-09 | 종근당바이오 주식회사 | 심바스타틴의 정제방법 |
CA2521276A1 (en) * | 2003-04-01 | 2004-10-14 | Ranbaxy Laboratories Limited | Fermentation process for the preparation of pravastatin |
US6978908B2 (en) * | 2003-09-15 | 2005-12-27 | Gerber Products Company | Drinking vessel with adjustable handles |
PT1641447E (pt) * | 2003-11-24 | 2008-12-10 | Teva Gyogyszergyar Zartkoeruee | Método de purificação da pravastatina |
ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
MX2007003652A (es) * | 2004-09-28 | 2009-02-16 | Teva Pharma | Proceso para preparar formas de calcio de atorvastatina sustancialmente libre de impurezas. |
CN102043030A (zh) * | 2009-10-22 | 2011-05-04 | 北京万全阳光医学技术有限公司 | 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法 |
CN102621238A (zh) * | 2011-02-01 | 2012-08-01 | 北京北大维信生物科技有限公司 | 一种测定HMG-CoA还原酶抑制剂浓度的方法 |
CN105985244A (zh) * | 2015-02-04 | 2016-10-05 | 北京北大维信生物科技有限公司 | 化合物、其分离方法、合成方法及用途 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
IT1232311B (it) | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
AU661996B2 (en) * | 1991-03-14 | 1995-08-17 | Kabushiki Kaisha Ace Denken | Stock control system |
US5420024A (en) * | 1993-05-11 | 1995-05-30 | Merck & Co., Inc. | Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea |
US5427686A (en) * | 1994-04-05 | 1995-06-27 | Sri International | Process for separating material from mixture using displacement chromatography |
EP0877089A1 (en) * | 1997-05-07 | 1998-11-11 | Gist-Brocades B.V. | HMG-CoA reductase inhibitor preparation process |
-
1998
- 1998-09-18 SI SI9800241A patent/SI20072A/sl not_active IP Right Cessation
-
1999
- 1999-09-17 NZ NZ509582A patent/NZ509582A/en not_active IP Right Cessation
- 1999-09-17 CN CNB998110760A patent/CN1186335C/zh not_active Expired - Fee Related
- 1999-09-17 CA CA002343645A patent/CA2343645A1/en not_active Abandoned
- 1999-09-17 DE DE69922519T patent/DE69922519T2/de not_active Expired - Lifetime
- 1999-09-17 EP EP99941797A patent/EP1114040B1/en not_active Expired - Lifetime
- 1999-09-17 PL PL345883A patent/PL200336B1/pl not_active IP Right Cessation
- 1999-09-17 RS YUP-818/00A patent/RS49996B/sr unknown
- 1999-09-17 RU RU2001108381/04A patent/RU2235098C2/ru not_active IP Right Cessation
- 1999-09-17 AT AT99941797T patent/ATE284396T1/de active
- 1999-09-17 WO PCT/IB1999/001553 patent/WO2000017182A1/en active IP Right Grant
- 1999-09-17 KR KR1020017000044A patent/KR100607608B1/ko not_active IP Right Cessation
- 1999-09-17 IL IL14205699A patent/IL142056A0/xx active IP Right Grant
- 1999-09-17 US US09/720,952 patent/US6695969B1/en not_active Expired - Fee Related
- 1999-09-17 RO ROA200100289A patent/RO121116B1/ro unknown
- 1999-09-17 JP JP2000574092A patent/JP3795755B2/ja not_active Expired - Fee Related
- 1999-09-17 SK SK2002-2000A patent/SK285868B6/sk not_active IP Right Cessation
- 1999-09-17 AU AU55284/99A patent/AU766630B2/en not_active Ceased
- 1999-09-17 HU HU0102997A patent/HUP0102997A2/hu unknown
-
2001
- 2001-01-16 HR HR20010045A patent/HRP20010045B1/xx not_active IP Right Cessation
- 2001-03-12 IS IS5886A patent/IS2149B/is unknown
- 2001-03-16 BG BG105348A patent/BG64676B1/bg unknown
- 2001-03-18 IL IL142056A patent/IL142056A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RO121116B1 (ro) | 2006-12-29 |
KR20010099584A (ko) | 2001-11-09 |
IS2149B (is) | 2006-10-13 |
SI20072A (sl) | 2000-04-30 |
JP2002526486A (ja) | 2002-08-20 |
SK285868B6 (sk) | 2007-10-04 |
HUP0102997A2 (hu) | 2001-12-28 |
HRP20010045A2 (en) | 2001-12-31 |
EP1114040B1 (en) | 2004-12-08 |
KR100607608B1 (ko) | 2006-08-02 |
RU2235098C2 (ru) | 2004-08-27 |
NZ509582A (en) | 2003-10-31 |
AU766630B2 (en) | 2003-10-23 |
SK20022000A3 (sk) | 2001-08-06 |
HRP20010045B1 (en) | 2005-08-31 |
DE69922519T2 (de) | 2005-12-08 |
ATE284396T1 (de) | 2004-12-15 |
IL142056A0 (en) | 2002-03-10 |
AU5528499A (en) | 2000-04-10 |
RS49996B (sr) | 2008-09-29 |
IS5886A (is) | 2001-03-12 |
US6695969B1 (en) | 2004-02-24 |
JP3795755B2 (ja) | 2006-07-12 |
IL142056A (en) | 2006-08-01 |
CA2343645A1 (en) | 2000-03-30 |
CN1186335C (zh) | 2005-01-26 |
DE69922519D1 (de) | 2005-01-13 |
WO2000017182A1 (en) | 2000-03-30 |
EP1114040A1 (en) | 2001-07-11 |
BG105348A (en) | 2001-11-30 |
PL345883A1 (en) | 2002-01-14 |
CN1318063A (zh) | 2001-10-17 |
BG64676B1 (bg) | 2005-11-30 |
PL200336B1 (pl) | 2008-12-31 |
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