IT1232311B - Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. - Google Patents

Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.

Info

Publication number
IT1232311B
IT1232311B IT8921613A IT2161389A IT1232311B IT 1232311 B IT1232311 B IT 1232311B IT 8921613 A IT8921613 A IT 8921613A IT 2161389 A IT2161389 A IT 2161389A IT 1232311 B IT1232311 B IT 1232311B
Authority
IT
Italy
Prior art keywords
acid
peptide
pseudo
peptidic
compound
Prior art date
Application number
IT8921613A
Other languages
English (en)
Other versions
IT8921613A0 (it
Inventor
Giuseppe Claudio Viscomi
Franco Cardinali
Maria Grazia Longobardi
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo Spa filed Critical Sclavo Spa
Priority to IT8921613A priority Critical patent/IT1232311B/it
Publication of IT8921613A0 publication Critical patent/IT8921613A0/it
Priority to ES90116366T priority patent/ES2060881T3/es
Priority to EP90116366A priority patent/EP0416416B1/en
Priority to AT90116366T priority patent/ATE97911T1/de
Priority to DE69004900T priority patent/DE69004900T2/de
Priority to US07/573,687 priority patent/US5043423A/en
Priority to CA002024250A priority patent/CA2024250A1/en
Priority to JP2232615A priority patent/JPH03118393A/ja
Application granted granted Critical
Publication of IT1232311B publication Critical patent/IT1232311B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/422—Displacement mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT8921613A 1989-09-04 1989-09-04 Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. IT1232311B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IT8921613A IT1232311B (it) 1989-09-04 1989-09-04 Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
ES90116366T ES2060881T3 (es) 1989-09-04 1990-08-27 Metodo de purificar compuestos de bajo peso molecular de estructura peptidica o pseudopeptidica.
EP90116366A EP0416416B1 (en) 1989-09-04 1990-08-27 Method for purifying low molecular weight compounds of peptide or pseudo-peptide structure
AT90116366T ATE97911T1 (de) 1989-09-04 1990-08-27 Verfahren zur reinigung von verbindungen, die ein niedriges molekulargewicht und eine peptidoder peptid-aehnliche struktur besitzen.
DE69004900T DE69004900T2 (de) 1989-09-04 1990-08-27 Verfahren zur Reinigung von Verbindungen, die ein niedriges Molekulargewicht und eine Peptid- oder Peptid-ähnliche Struktur besitzen.
US07/573,687 US5043423A (en) 1989-09-04 1990-08-28 Method for purifying low molecular weight compounds of peptide or pseudo-peptide structure
CA002024250A CA2024250A1 (en) 1989-09-04 1990-08-29 Method for purifying low molecular weight compounds of peptide of pseudo-peptide structure
JP2232615A JPH03118393A (ja) 1989-09-04 1990-09-04 ペプチド又はプソイドペプチド構造の低分子量化合物の精製方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921613A IT1232311B (it) 1989-09-04 1989-09-04 Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.

Publications (2)

Publication Number Publication Date
IT8921613A0 IT8921613A0 (it) 1989-09-04
IT1232311B true IT1232311B (it) 1992-01-28

Family

ID=11184338

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921613A IT1232311B (it) 1989-09-04 1989-09-04 Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.

Country Status (8)

Country Link
US (1) US5043423A (it)
EP (1) EP0416416B1 (it)
JP (1) JPH03118393A (it)
AT (1) ATE97911T1 (it)
CA (1) CA2024250A1 (it)
DE (1) DE69004900T2 (it)
ES (1) ES2060881T3 (it)
IT (1) IT1232311B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545328A (en) * 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5478924A (en) * 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5662885A (en) * 1994-07-22 1997-09-02 Resolution Pharmaceuticals Inc. Peptide derived radionuclide chelators
SI9500040B (sl) * 1995-02-07 2002-02-28 Lek, Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC
US6239262B1 (en) 1998-01-07 2001-05-29 Rensselaer Polytechnic Institute Low molecular weight displacers for protein purification in hydrophobic interaction and reversed phase chromatographic systems
US7141602B2 (en) 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6573373B1 (en) 1999-06-29 2003-06-03 Isis Pharmaceuticals, Inc. High affinity, low molecular weight displacers for oligonucleotide purification
WO2003074148A1 (en) 2002-02-28 2003-09-12 Rensselaer Polytechnic Institute High-affinity, low-molecular-mass displacers for ion-exchange chromatography
RU2510398C2 (ru) * 2012-06-05 2014-03-27 Лариса Владимировна Волкова Способ выделения низкомолекулярных пептидов

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3778426A (en) * 1970-12-16 1973-12-11 Research Corp Therapeutically useful polypeptides
JPH06794B2 (ja) * 1984-03-02 1994-01-05 武田薬品工業株式会社 グルタミン酸レセプタ−阻害物質
DE3783280T2 (de) * 1986-07-16 1993-05-06 Eniricerche Spa Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.

Also Published As

Publication number Publication date
JPH03118393A (ja) 1991-05-20
US5043423A (en) 1991-08-27
EP0416416A1 (en) 1991-03-13
DE69004900D1 (de) 1994-01-13
ES2060881T3 (es) 1994-12-01
EP0416416B1 (en) 1993-12-01
DE69004900T2 (de) 1994-06-16
IT8921613A0 (it) 1989-09-04
ATE97911T1 (de) 1993-12-15
CA2024250A1 (en) 1991-03-05

Similar Documents

Publication Publication Date Title
IT1232311B (it) Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
Mebs et al. Purification, properties and amino acid sequence of α-bungarotoxin from the venom of Bungarus multicinctus
US3528960A (en) N-carboxyaroyl insulins
DE68913935T2 (de) Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
Suzuki et al. An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution.
DE69034040D1 (de) Rekombinanter Abkömmling des menschlichen Faktors VIII
Kim et al. Tyr13 is essential for the activity of ω-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers
KR920006372A (ko) 크로마토그래피에 의해 인슐린을 정제하는 방법
Yanagawa et al. Synthesis of polypeptides by microwave heating I. Formation of polypeptides during repeated hydration-dehydration cycles and their characterization
Suzuki et al. Optimazation of the loop length for folding of a helix-loop-helix peptide
GR890100285A (el) Μεθοδος δια την παραγωγη αλατων δια προσθηκης οξεος αμιδιωθεισησταυρινης η γλυκινης.
KR910019957A (ko) 아민-말단을 갖는 화합물의 제조방법
CA1044227A (en) Process for the manufacture of insulin, analogs and derivatives thereof
CN1164611C (zh) 丙-谷二肽合成方法
Sipos et al. Two‐dimensional proton‐NMR studies on a hybrid peptide between cecropin A and melittin: Resonance assignments and secondary structure
JPS6087299A (ja) ナチユラルキラ−細胞活性増大用ペプチド
CN104356221A (zh) 一种制备培西加南的方法
Seligy et al. Species variability of N-terminal sequence of avian erythrocyte-specific histone H5
US4533494A (en) Process for purifying secretin
Müller et al. Synthesis of N‐carboxyalkyl and N‐aminoalkyl functionalized dipeptide building units for the assembly of backbone cyclic peptides
EP0665239A1 (en) Peptide derivatives of bactenecin endowed with antibacterial activity
US5891995A (en) Substituted benzhydrylamines as handles for solid phase peptide synthesis
DE68905097D1 (de) Peptid-molekuele, wirksam gegen gram-positive keime.
US4230696A (en) Polypeptides useful for the purpose of treating multiple sclerosis
Timpl et al. Cyanogen bromide cleavage of bovine fibrinogen. Identification of a dimeric N-terminal peptide and two other disulfide containing fragments

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970427