SI9500040B - Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC - Google Patents
Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC Download PDFInfo
- Publication number
- SI9500040B SI9500040B SI9500040A SI9500040A SI9500040B SI 9500040 B SI9500040 B SI 9500040B SI 9500040 A SI9500040 A SI 9500040A SI 9500040 A SI9500040 A SI 9500040A SI 9500040 B SI9500040 B SI 9500040B
- Authority
- SI
- Slovenia
- Prior art keywords
- mobile phase
- mmol
- displacement
- acid
- concentration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (32)
1 PATENTNI ZAHTEVKI 1. Metoda za čiščenje vankomicinskih antibiotikov s kromatografijo izpodrivanja, označena s tem, da je stacionarna faza naravna ali sintetična reverzna faza, mobilna faza je razredčena kislina ali pufer, izpodrivalo pa je alkohol, oksialkohol (alkohol-eter), alkil sulfat alkalijske kovine ali tetraalkil amonijev halogenid.
2. Metoda po zahtevku 1, označena s tem, da se uporablja za čiščenje vankomicin hidroklorida.
3. Metoda po zahtevku 1, označena s tem, daje stacionarna faza oktadecil silikagel.
4. Metoda po zahtevku 1, označena s tem, da je stacionarna faza izbrana izmed sintetičnih polimerov, kijih sestavljata stiren in divinilbenzen.
5. Metoda po zahtevku 1, označena s tem, daje povprečni premer delcev, iz katerih je sestavljena stacionarna faza, med približno 2 pm in približno 100 pm.
6. Metoda po zahtevku 1, označena s tem, daje povprečni premer delcev, iz katerih je sestavljena stacionarna faza, približno 12 pm.
7. Metoda po zahtevku 1, označena s tem, da je razmerje med količino nanesene substance in stacionarno fazo največ približno 1:3.
8. Metoda po zahtevku 7, označena s tem, je razmerje med količino nanesene substance in stacionarno fazo približno 1:8.
9. Metoda po zahtevku 1, označena s tem, daje koncentracija substance v mobilni fazi med približno 0,5 mmol/1 in približno 150 mmol/1. 2
10. Metoda po zahtevku 9, označena s tem, daje koncentracija substance v mobilni fazi približno 50 mmol/1.
11. Metoda po zahtevku 1, označena s tem, da je pH mobilne faze med približno 2 in približno 10.
12. Metoda po zahtevku 11, označena s tem, da je pH mobilne faze med približno 2 in približno 6.
13. Metoda po zahtevku 11, označena s tem, daje kislina v mobilni fazi organska kislina, in sicer mravljinčna kislina, ocetna kislina ali propionska kislina, njen halogeniran derivat ali organski ali anorganski pufer ene od teh kislin.
14. Metoda po zahtevku 13, označena s tem, daje kislina v mobilni fazi ocetna kislina ali amonijev acetatni pufer.
15. Metoda po zahtevku 11, označena s tem, daje kislina v mobilni fazi anorganska, in sicer HC1, ali v obliki boratnega, fosfatnega, sulfatnega ali kloridnega pufra, pri čemer so kationi anorganski, amoniak ali različni amini.
16. Metoda po zahtevku 11, označena s tem, daje koncentracija kisline v mobilni fazi med približno 2 mmol/1 in približno 500 mmol/1.
17. Metoda po zahtevku 16, označena s tem, daje koncentracija kisline v mobilni fazi približno 40 mmol/1.
18. Metoda po zahtevku 1, označena s tem, da dodamo mobilni fazi metanol, etanol, propanol, acetonitril, tetrahidrofuran ali kombinacijo le-teh.
19. Metoda po zahtevku 18, označena s tem, daje alkohol v mobilni fazi metanol. 3
20. Metoda po zahtevku 18, označena s tem, daje alkohol v mobilni fazi etanol.
21. Metoda po zahtevku 18, označena s tem, daje koncentracija dodatka k mobilni fazi med približno 0,5 in približno 10 %.
22. Metoda po zahtevku 21, označena s tem, da je koncentracija dodatka k mobilni fazi približno 2 %.
23. Metoda po zahtevku 1, označena s tem, daje izpodrivalo alkohol z vsaj C4-verigo.
24. Metoda po zahtevku 23, označena s tem, daje izpodrivalo butanol.
25. Metoda po zahtevku 23, označena s tem, daje izpodrivalo pentanol.
26. Metoda po zahtevku 1, označena s tem, daje izpodrivalo 2-etoksietanol.
27. Metoda po zahtevku 1, označena s tem, da je izpodrivalo tetraalkilamonijev halogenid.
28. Metoda po zahtevku 27, označena s tem, daje izpodrivalo cetil trimetil amonijev bromid.
29. Metoda po zahtevku 1, označena s tem, daje izpodrivalo alkil sulfat alkalijske kovine ali njegov derivat z -OH skupino v alkilni verigi.
30. Metoda po zahtevku 29, označena s tem, daje izpodrivalo natrijev dodecil sulfat.
31. Metoda po zahtevku 1, označena s tem, daje koncentracija izpodrivala v mobilni fazi med približno 10 mmol/1 in približno 1000 mmol/1. 4
32. Metoda po zahtevku 31, označena s tem, daje koncentracija izpodrivala v mobilni fazi približno 200 mmol/1.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9500040A SI9500040B (sl) | 1995-02-07 | 1995-02-07 | Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC |
JP8524214A JPH10513195A (ja) | 1995-02-07 | 1996-02-06 | 分取hplcの使用によるバンコマイシン塩酸塩のクロマトグラフ精製 |
US08/875,442 US5854390A (en) | 1995-02-07 | 1996-02-06 | Chromatographic purification of vancomycin hydrochloride by use of preparative HPLC |
PCT/SI1996/000002 WO1996024614A1 (en) | 1995-02-07 | 1996-02-06 | Chromatographic purification of vancomycin hydrochloride by the use of preparative hplc |
EP96901182A EP0808331A1 (en) | 1995-02-07 | 1996-02-06 | Chromatographic purification of vancomycin hydrochloride by the use of preparative hplc |
CA002210987A CA2210987C (en) | 1995-02-07 | 1996-02-06 | Chromatographic purification of vancomycin hydrochloride by the use of preparative hplc |
AU45002/96A AU4500296A (en) | 1995-02-07 | 1996-02-06 | Chromatographic purification of vancomycin hydrochloride by the use of preparative hplc |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9500040A SI9500040B (sl) | 1995-02-07 | 1995-02-07 | Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9500040A SI9500040A (en) | 1996-08-31 |
SI9500040B true SI9500040B (sl) | 2002-02-28 |
Family
ID=20431543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9500040A SI9500040B (sl) | 1995-02-07 | 1995-02-07 | Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC |
Country Status (7)
Country | Link |
---|---|
US (1) | US5854390A (sl) |
EP (1) | EP0808331A1 (sl) |
JP (1) | JPH10513195A (sl) |
AU (1) | AU4500296A (sl) |
CA (1) | CA2210987C (sl) |
SI (1) | SI9500040B (sl) |
WO (1) | WO1996024614A1 (sl) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI21924A (sl) * | 2004-12-07 | 2006-06-30 | Lek Farmacevtska Druzba D.D. | Cist vankomicin hidroklorid |
EP1798237A1 (en) * | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Process for the purification of macrolide antibiotics |
US20090275768A1 (en) * | 2008-04-30 | 2009-11-05 | Formosa Laboratories, Inc. | Preparation of Paricalcitol |
CN102323121A (zh) * | 2011-06-27 | 2012-01-18 | 扬州大学 | 一种从鸡蛋中同时提取并衍生化阿莫西林和氨苄西林的方法 |
CN102590392B (zh) * | 2012-03-14 | 2013-10-30 | 齐鲁制药有限公司 | 一种阿奇霉素缓释滴眼液中阿奇霉素的含量测定方法 |
CN111103363B (zh) * | 2018-10-26 | 2024-03-22 | 复旦大学附属华山医院 | 测定人血清中万古霉素和降解产物浓度的方法 |
CN113484439B (zh) * | 2021-07-19 | 2023-06-02 | 亿腾医药(亚洲)澳门离岸商业服务有限公司 | 基于二维高效液相色谱-高分辨质谱的万古霉素组分结构分析方法及万古霉素b开环物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4667024A (en) * | 1983-07-13 | 1987-05-19 | Smithkline Beckman Corporation | Process for the preparation of purified vancomycin class antibiotics |
IT1232311B (it) * | 1989-09-04 | 1992-01-28 | Sclavo Spa | Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare. |
-
1995
- 1995-02-07 SI SI9500040A patent/SI9500040B/sl not_active IP Right Cessation
-
1996
- 1996-02-06 EP EP96901182A patent/EP0808331A1/en not_active Withdrawn
- 1996-02-06 WO PCT/SI1996/000002 patent/WO1996024614A1/en active Application Filing
- 1996-02-06 JP JP8524214A patent/JPH10513195A/ja active Pending
- 1996-02-06 CA CA002210987A patent/CA2210987C/en not_active Expired - Fee Related
- 1996-02-06 US US08/875,442 patent/US5854390A/en not_active Expired - Fee Related
- 1996-02-06 AU AU45002/96A patent/AU4500296A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
SI9500040A (en) | 1996-08-31 |
CA2210987A1 (en) | 1996-08-15 |
EP0808331A1 (en) | 1997-11-26 |
JPH10513195A (ja) | 1998-12-15 |
US5854390A (en) | 1998-12-29 |
CA2210987C (en) | 2001-10-02 |
AU4500296A (en) | 1996-08-27 |
WO1996024614A1 (en) | 1996-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI9500040B (sl) | Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC | |
Ingersoll et al. | Vitamin D3-induced calcium-binding protein: binding characteristics, conformational effects, and other properties | |
NO20011271D0 (no) | FremgangsmÕte for fremstilling av ren citalopram | |
AP1709A (en) | Ethanolate of azithromycin, process for manufacure, and pharmaceutical compositions thereof. | |
HRP20020480B1 (en) | Process for the purification of pharmacologically active proteins through cationic exchange chromatography | |
DE60122522D1 (de) | Pektine mit niedrigem methoxylgrad, verfahren zu deren herstellung und stabilisierte, wässrige systeme, die diese pektine enthalten | |
Middaugh et al. | Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. | |
FR2771090B1 (fr) | Procede de preparation de derives de bromomethyl-biphenyle | |
ATE461186T1 (de) | Salz eines 7-isoindolinchinoloncarbonsäure- derivats, sein monohydrat und zusammensetzungen die diese als wirksamen bestandteil enthalten | |
BR9202332A (pt) | Sistema catalitico de hidrocloracao e processo de fabricacao de cloreto de vinila | |
AU593242B2 (en) | Improvements in or relating to a process for purifying proinsulin-like materials | |
KR950700311A (ko) | 3-세펨-4-카복실산 유도체의 정제방법(Process for the purification of a 3-cephem-4-carboxylic acid derivatives) | |
CA2210990A1 (en) | New combined process for the purification of vancomycin hydrochloride | |
ATE237660T1 (de) | Disazoverbindungen und ihre herstellungsverfahren | |
CA2531969A1 (en) | Protein-refolding material | |
PT988263E (pt) | Processo para a producao de agentes neurorreceptores radioiodados | |
FR2690444B1 (fr) | Procede de preparation d'une solution d'albumine plasmatique purifiee. | |
EA199900765A1 (ru) | Новые производные эритромицина, способ их получения и их применение в качестве лекарственных средств | |
KR960031472A (ko) | 1-엔(n)-에틸시소마이신의 제조방법 | |
FR2739097B1 (fr) | Procede de purification de paraxylene par cristallisation fractionnee | |
BR0110774A (pt) | Processo para purificação de um sal de ácido clavulânico | |
Ducep et al. | Synthesis of (2S, 5S)-5-fluoromethylornithine; a potent inhibitor of ornithine aminotransferase | |
KUROKI et al. | Reactivities of various amines in the modifications of acetic acid and aspartic acid-101 of lysozyme in the carbodiimide reaction | |
SU1392902A1 (ru) | Способ выделени и очистки бактериальной эндонуклеазы из культуральной жидкости SеRRатIа маRсеSсеUS | |
Pocker et al. | Electrophilic catalysis in nucleophilic substitution and elimination. VIII. Kinetics and mechanism of reaction of tert-amyl and 1-adamantylcarbinyl halides with silver salts in acetonitrile |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF | Valid on the event date | ||
KO00 | Lapse of patent |
Effective date: 20100917 |