IS2149B - Aðferð til að öðlast mjög hreina HMG-CoA redúktasatálma - Google Patents

Aðferð til að öðlast mjög hreina HMG-CoA redúktasatálma

Info

Publication number
IS2149B
IS2149B IS5886A IS5886A IS2149B IS 2149 B IS2149 B IS 2149B IS 5886 A IS5886 A IS 5886A IS 5886 A IS5886 A IS 5886A IS 2149 B IS2149 B IS 2149B
Authority
IS
Iceland
Prior art keywords
coa reductase
reductase inhibitors
hmg
purity
chemical synthesis
Prior art date
Application number
IS5886A
Other languages
English (en)
Other versions
IS5886A (is
Inventor
Grahek Rok
Milivojevic Dusan
Bastarda Andrej
Original Assignee
Lek Pharmaceutical And Chemical Company D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceutical And Chemical Company D.D. filed Critical Lek Pharmaceutical And Chemical Company D.D.
Publication of IS5886A publication Critical patent/IS5886A/is
Publication of IS2149B publication Critical patent/IS2149B/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/422—Displacement mode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
IS5886A 1998-09-18 2001-03-12 Aðferð til að öðlast mjög hreina HMG-CoA redúktasatálma IS2149B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800241A SI20072A (sl) 1998-09-18 1998-09-18 Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
PCT/IB1999/001553 WO2000017182A1 (en) 1998-09-18 1999-09-17 PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY

Publications (2)

Publication Number Publication Date
IS5886A IS5886A (is) 2001-03-12
IS2149B true IS2149B (is) 2006-10-13

Family

ID=20432332

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5886A IS2149B (is) 1998-09-18 2001-03-12 Aðferð til að öðlast mjög hreina HMG-CoA redúktasatálma

Country Status (22)

Country Link
US (1) US6695969B1 (is)
EP (1) EP1114040B1 (is)
JP (1) JP3795755B2 (is)
KR (1) KR100607608B1 (is)
CN (1) CN1186335C (is)
AT (1) ATE284396T1 (is)
AU (1) AU766630B2 (is)
BG (1) BG64676B1 (is)
CA (1) CA2343645A1 (is)
DE (1) DE69922519T2 (is)
HR (1) HRP20010045B1 (is)
HU (1) HUP0102997A2 (is)
IL (2) IL142056A0 (is)
IS (1) IS2149B (is)
NZ (1) NZ509582A (is)
PL (1) PL200336B1 (is)
RO (1) RO121116B1 (is)
RS (1) RS49996B (is)
RU (1) RU2235098C2 (is)
SI (1) SI20072A (is)
SK (1) SK285868B6 (is)
WO (1) WO2000017182A1 (is)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
ATE342717T1 (de) * 1999-11-30 2006-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
US7001919B2 (en) * 1999-12-14 2006-02-21 Teva Gyogyszergyar Reszvenytarsasag Forms of pravastatin sodium
US6521762B2 (en) * 2000-03-03 2003-02-18 BIOGAL Gyógyszergyar RT. Process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
PL361230A1 (en) * 2000-10-05 2004-10-04 Biogal Gyogyszergyar Rt. Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US6936731B2 (en) 2000-10-05 2005-08-30 TEVA Gyógyszergyár Részvénytársaság Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
KR100407758B1 (ko) * 2001-08-27 2003-12-01 씨제이 주식회사 스타틴의 제조에 있어서 락톤화 방법
JP2003093045A (ja) * 2001-09-26 2003-04-02 Godo Shusei Co Ltd 有用変換微生物
KR100435078B1 (ko) * 2002-02-08 2004-06-09 종근당바이오 주식회사 심바스타틴의 정제방법
WO2004087935A2 (en) * 2003-04-01 2004-10-14 Ranbaxy Laboratories Limited Fermentation process for the preparation of pravastatin
US6978908B2 (en) * 2003-09-15 2005-12-27 Gerber Products Company Drinking vessel with adjustable handles
CA2546377A1 (en) 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
KR100881103B1 (ko) * 2004-09-28 2009-02-02 테바 파마슈티컬 인더스트리즈 리미티드 실질적으로 불순물을 함유하지 않는 아토르바스타틴 칼슘의형태를 제조하는 방법
CN102043030A (zh) * 2009-10-22 2011-05-04 北京万全阳光医学技术有限公司 一种用高效液相色谱法测定烟酸辛伐他汀缓释片有关物质的方法
CN102621238A (zh) * 2011-02-01 2012-08-01 北京北大维信生物科技有限公司 一种测定HMG-CoA还原酶抑制剂浓度的方法
CN105985244A (zh) * 2015-02-04 2016-10-05 北京北大维信生物科技有限公司 化合物、其分离方法、合成方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
IT1232311B (it) * 1989-09-04 1992-01-28 Sclavo Spa Metodo di purificazione di composti a struttura peptidica o pseudo peptidica a basso peso molecolare.
US5202029A (en) * 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
AU661996B2 (en) * 1991-03-14 1995-08-17 Kabushiki Kaisha Ace Denken Stock control system
US5420024A (en) * 1993-05-11 1995-05-30 Merck & Co., Inc. Process for synthesis of acylated HMG-CoA reductase inhibitors from a lactone diol precursor using Candida cylindracea
US5427686A (en) * 1994-04-05 1995-06-27 Sri International Process for separating material from mixture using displacement chromatography
EP0877089A1 (en) * 1997-05-07 1998-11-11 Gist-Brocades B.V. HMG-CoA reductase inhibitor preparation process

Also Published As

Publication number Publication date
SK20022000A3 (sk) 2001-08-06
IL142056A (en) 2006-08-01
KR100607608B1 (ko) 2006-08-02
ATE284396T1 (de) 2004-12-15
HUP0102997A2 (hu) 2001-12-28
JP2002526486A (ja) 2002-08-20
PL200336B1 (pl) 2008-12-31
CA2343645A1 (en) 2000-03-30
IS5886A (is) 2001-03-12
RS49996B (sr) 2008-09-29
AU766630B2 (en) 2003-10-23
SI20072A (sl) 2000-04-30
BG105348A (en) 2001-11-30
EP1114040B1 (en) 2004-12-08
AU5528499A (en) 2000-04-10
CN1318063A (zh) 2001-10-17
HRP20010045B1 (en) 2005-08-31
CN1186335C (zh) 2005-01-26
KR20010099584A (ko) 2001-11-09
YU81800A (sh) 2003-02-28
RU2235098C2 (ru) 2004-08-27
US6695969B1 (en) 2004-02-24
PL345883A1 (en) 2002-01-14
HRP20010045A2 (en) 2001-12-31
IL142056A0 (en) 2002-03-10
SK285868B6 (sk) 2007-10-04
NZ509582A (en) 2003-10-31
JP3795755B2 (ja) 2006-07-12
EP1114040A1 (en) 2001-07-11
DE69922519T2 (de) 2005-12-08
DE69922519D1 (de) 2005-01-13
BG64676B1 (bg) 2005-11-30
WO2000017182A1 (en) 2000-03-30
RO121116B1 (ro) 2006-12-29

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