AR023368A1 - Proceso microbiano para preparar pravastatina - Google Patents

Proceso microbiano para preparar pravastatina

Info

Publication number
AR023368A1
AR023368A1 ARP000100484A ARP000100484A AR023368A1 AR 023368 A1 AR023368 A1 AR 023368A1 AR P000100484 A ARP000100484 A AR P000100484A AR P000100484 A ARP000100484 A AR P000100484A AR 023368 A1 AR023368 A1 AR 023368A1
Authority
AR
Argentina
Prior art keywords
compound
formula
6beta
hydroxylating
purifying
Prior art date
Application number
ARP000100484A
Other languages
English (en)
Original Assignee
Inst Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Drug Res Ltd filed Critical Inst Drug Res Ltd
Publication of AR023368A1 publication Critical patent/AR023368A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente se relaciona con un nuevo proceso microbiano para la preparacion del compuesto de la formula (1) a partir de un compuesto de la formula general(2), donde R representa un ion de metal alcalino o de amonio, por el cultivo sumergido de una cepa de moho capaz de 6Beta-hidroxilar un compuesto de la formula(1) en fermentacion aerobica y por separacion y purificacion del producto de la formula (1) formada en el curso de la bioconversion. El proceso comprendecultivar una cepa de especie de moho filamentoso Mortierella maculata que es capaz de 6Beta-hidroxilar un compuesto de la formula general (2), en un medionutriente que contiene caldo de fermentacion asimilable, aislando luego el compuesto de la formula (1) y purificándolo. También se revelan cepas nuevas deMortierella maculata.
ARP000100484A 1999-02-03 2000-02-04 Proceso microbiano para preparar pravastatina AR023368A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18

Publications (1)

Publication Number Publication Date
AR023368A1 true AR023368A1 (es) 2002-09-04

Family

ID=26816384

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP000100484A AR023368A1 (es) 1999-02-03 2000-02-04 Proceso microbiano para preparar pravastatina
ARP070102941A AR061765A2 (es) 1999-02-03 2007-06-29 Proceso para la preparcion de sal de sodio de pravastatina en una forma cristalina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP070102941A AR061765A2 (es) 1999-02-03 2007-06-29 Proceso para la preparcion de sal de sodio de pravastatina en una forma cristalina

Country Status (27)

Country Link
EP (1) EP1154979B1 (es)
JP (2) JP3645491B2 (es)
KR (2) KR100648541B1 (es)
CN (3) CN1260344C (es)
AR (2) AR023368A1 (es)
AT (1) ATE294771T1 (es)
AU (2) AU774438B2 (es)
BG (1) BG105778A (es)
BR (1) BR0009180A (es)
CA (1) CA2361701C (es)
CZ (1) CZ20012761A3 (es)
DE (1) DE60019898T2 (es)
ES (1) ES2240072T3 (es)
HK (1) HK1042686B (es)
HR (1) HRP20010577B1 (es)
HU (1) HUP0200650A3 (es)
IL (1) IL144697A0 (es)
IS (1) IS6036A (es)
MX (1) MXPA01007807A (es)
NO (1) NO20013818L (es)
PL (1) PL350317A1 (es)
PT (1) PT1154979E (es)
RU (1) RU2004127981A (es)
SK (1) SK10932001A3 (es)
TR (2) TR200103127T2 (es)
WO (1) WO2000046175A1 (es)
YU (1) YU55701A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
DE60031447T2 (de) * 1999-11-30 2007-08-30 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
SK8312002A3 (en) 1999-12-14 2003-05-02 Biogal Gyogyszergyar Novel forms of pravastatin sodium
SK5232003A3 (en) * 2000-10-05 2004-06-08 Biogal Gyogyszergyar Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
JP4616168B2 (ja) * 2003-04-25 2011-01-19 日本ケミファ株式会社 （２ｓ，３ｓ）−３−［［（１ｓ）−１−イソブトキシメチル−３−メチルブチル］カルバモイル］オキシラン−２−カルボン酸の塩
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
SI2274267T1 (sl) * 2008-04-02 2012-04-30 Dsm Sinochem Pharmaceuticals Nl B V Ekstrakcija pravastatina
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104017734A (zh) * 1996-03-28 2014-09-03 Dsmip资产有限公司 粒状微生物生物质的制备及其有价值的化合物的分离方法

Also Published As

Publication number Publication date
MXPA01007807A (es) 2003-06-04
HUP0200650A2 (en) 2002-08-28
JP2005047924A (ja) 2005-02-24
JP4197312B2 (ja) 2008-12-17
EP1154979A1 (en) 2001-11-21
BG105778A (bg) 2002-05-31
SK10932001A3 (sk) 2002-06-04
TR200600009T2 (tr) 2006-08-21
CA2361701A1 (en) 2000-08-10
JP3645491B2 (ja) 2005-05-11
RU2004127981A (ru) 2006-03-10
ATE294771T1 (de) 2005-05-15
AU774438B2 (en) 2004-06-24
AU3356700A (en) 2000-08-25
BR0009180A (pt) 2002-03-26
CN1537935A (zh) 2004-10-20
HRP20010577A2 (en) 2002-12-31
HUP0200650A3 (en) 2008-03-28
NO20013818D0 (no) 2001-08-03
HK1042686A1 (en) 2002-08-23
YU55701A (sh) 2004-07-15
PL350317A1 (en) 2002-12-02
WO2000046175A1 (en) 2000-08-10
HRP20010577B1 (en) 2005-12-31
JP2002535977A (ja) 2002-10-29
DE60019898D1 (de) 2005-06-09
CN1177793C (zh) 2004-12-01
CA2361701C (en) 2007-04-10
CN1590363A (zh) 2005-03-09
KR20060061406A (ko) 2006-06-07
CN1260344C (zh) 2006-06-21
AR061765A2 (es) 2008-09-17
KR20010112257A (ko) 2001-12-20
PT1154979E (pt) 2005-08-31
IS6036A (is) 2001-08-02
EP1154979B1 (en) 2005-05-04
ES2240072T3 (es) 2005-10-16
CZ20012761A3 (cs) 2002-05-15
EP1154979A4 (en) 2004-05-26
CN1347400A (zh) 2002-05-01
DE60019898T2 (de) 2006-08-10
TR200103127T2 (tr) 2002-04-22
NO20013818L (no) 2001-10-03
HK1042686B (zh) 2005-10-14
IL144697A0 (en) 2002-06-30
KR100648541B1 (ko) 2006-11-24
AU2004214559A1 (en) 2004-10-21

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