WO1999012958A3 - Ampullosporin, verfahren zu dessen herstellung und dessen verwendung - Google Patents

Ampullosporin, verfahren zu dessen herstellung und dessen verwendung Download PDF

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Publication number
WO1999012958A3
WO1999012958A3 PCT/DE1998/002654 DE9802654W WO9912958A3 WO 1999012958 A3 WO1999012958 A3 WO 1999012958A3 DE 9802654 W DE9802654 W DE 9802654W WO 9912958 A3 WO9912958 A3 WO 9912958A3
Authority
WO
WIPO (PCT)
Prior art keywords
aib
ampullosporin
sepedonium
dsm
spec
Prior art date
Application number
PCT/DE1998/002654
Other languages
English (en)
French (fr)
Other versions
WO1999012958A2 (de
Inventor
Brigitte Schlegel
Werner Fleck
Heinrich Doerfelt
Udo Graefe
Michael Ritzau
Stephan Heinze
Albert Haertl
Klausjuergen Dornberger
Original Assignee
Knoell Hans Forschung Ev
Brigitte Schlegel
Werner Fleck
Heinrich Doerfelt
Udo Graefe
Michael Ritzau
Stephan Heinze
Albert Haertl
Klausjuergen Dornberger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoell Hans Forschung Ev, Brigitte Schlegel, Werner Fleck, Heinrich Doerfelt, Udo Graefe, Michael Ritzau, Stephan Heinze, Albert Haertl, Klausjuergen Dornberger filed Critical Knoell Hans Forschung Ev
Publication of WO1999012958A2 publication Critical patent/WO1999012958A2/de
Publication of WO1999012958A3 publication Critical patent/WO1999012958A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung betrifft eine neue neuroleptisch wirksame Substanz vom Strukturtyp der Peptaibole mit der Bezeichnung Ampullosporin, die aus der Kulturbrühe des Mikroorganismus Sepedonium spec. DSM 10602 erhältlich ist. Acetyl-L-Trp-L-Ala-Aib-Aib-L-Leu-Aib-L-Glu-Aib-Aib-Aib-L-Gln-L-Leu-Aib-L-Gln-L-Leucinol. Zur Herstellung wird der Mikroorganismus Sepedonium spec. DSM 10602 unter emersen, submersen und sterilen Kulturbedingungen angezogen. Das gebildete Ampullosporin wird als einheitliche Komponente aus der Kulturbrühe mit organischen Lösungsmitteln extrahiert und anschließend in reiner Form durch die Anwendung üblicher chromatografischer Reinigungsschritte gewonnen. Ampullosporin besitzt eine starke neuroleptische Wirkung und ist für die Herstellung pharmazeutischer Zubereitungen geeignet.
PCT/DE1998/002654 1997-09-11 1998-09-08 Ampullosporin, verfahren zu dessen herstellung und dessen verwendung WO1999012958A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19740030.2 1997-09-11
DE19740030A DE19740030A1 (de) 1997-09-11 1997-09-11 Ampullosporin, Verfahren zu dessen Herstellung und dessen Verwendung

Publications (2)

Publication Number Publication Date
WO1999012958A2 WO1999012958A2 (de) 1999-03-18
WO1999012958A3 true WO1999012958A3 (de) 1999-06-10

Family

ID=7842070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1998/002654 WO1999012958A2 (de) 1997-09-11 1998-09-08 Ampullosporin, verfahren zu dessen herstellung und dessen verwendung

Country Status (2)

Country Link
DE (1) DE19740030A1 (de)
WO (1) WO1999012958A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19948644A1 (de) * 1999-10-01 2001-04-05 Knoell Hans Forschung Ev Neue Peptaibole mit neuroleptischer Wirkung
DE10061525A1 (de) * 2000-12-08 2002-06-20 Knoell Hans Forschung Ev Lipophile Oligopeptide als Carrier für Pharmaka
DE10222792A1 (de) * 2002-05-23 2003-12-04 Aventis Pharma Gmbh Neue Verwendung von Cephaibolen
US7041649B2 (en) 2002-05-23 2006-05-09 Sanofi-Aventis Deutschland Gmbh Method for treating neurological conditions and inducing immunosuppression with cephaibols
CN1332979C (zh) * 2004-12-27 2007-08-22 山东大学 新型抗生素肽哌珀霉素及其制备工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0622375A1 (de) * 1993-02-20 1994-11-02 Hoechst Aktiengesellschaft Chrysospermine, Peptidwirkstoffe aus Apiocrea chrysosperma mit pharmakologischer Wirkung, ein Verfahren zu Herstellung und Verwendung derselben

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0622375A1 (de) * 1993-02-20 1994-11-02 Hoechst Aktiengesellschaft Chrysospermine, Peptidwirkstoffe aus Apiocrea chrysosperma mit pharmakologischer Wirkung, ein Verfahren zu Herstellung und Verwendung derselben

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIOCHIM. BIOPHYS. ACTA (1995), 1237 (1), 1-5 CODEN: BBACAQ;ISSN: 0006-3002 *
CHEMICAL ABSTRACTS, vol. 123, no. 9, 28 August 1995, Columbus, Ohio, US; abstract no. 102102, GRIGORIEV, PAVEL ET AL: "Formation of membrane channels by chrysospermins, new peptaibol antibiotics" XP002100480 *
GRIGORIEV, P. A. ET AL: "Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics", BIOELECTROCHEM. BIOENERG. (1997), 44(1), 155-158 CODEN: BEBEBP;ISSN: 0302-4598, XP002100478 *
RITZAU, MICHAEL ET AL: "Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice", J. ANTIBIOT. (1997), 50(9), 722-728 CODEN: JANTAJ;ISSN: 0021-8820, September 1997 (1997-09-01), XP002100479 *

Also Published As

Publication number Publication date
WO1999012958A2 (de) 1999-03-18
DE19740030A1 (de) 1999-03-18

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