MXPA01007807A - Proceso microbiano para preparar pravastatina. - Google Patents
Proceso microbiano para preparar pravastatina.Info
- Publication number
- MXPA01007807A MXPA01007807A MXPA01007807A MXPA01007807A MXPA01007807A MX PA01007807 A MXPA01007807 A MX PA01007807A MX PA01007807 A MXPA01007807 A MX PA01007807A MX PA01007807 A MXPA01007807 A MX PA01007807A MX PA01007807 A MXPA01007807 A MX PA01007807A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- formula
- 6beta
- hydroxylate
- strain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invencion se relaciona con un nuevo proceso microbiano para la preparacion del compuesto de la formula (I) (ver formula I) de un compuesto de la formula general (II) (ver formula II) donde R representa un ion de metal alcalino o de amonio, por el cultivo sumergido de una cepa de moho capaz de 6°-hidroxilar un compuesto de la Formula (I) en fermentacion aerobica y por separacion y purificacion del producto de la Formula (I) formada en el curso de la bioconversion. El proceso comprende cultivar una cepa de especie de moho filamentoso Mortierella maculata que es capaz de 6°-hidroxilar un compuesto de la Formula general (II), en un medio nutriente que contiene fuentes asimilables de carbono y nitrogeno y sales minerales y separar el producto formado del caldo de fermentacion, aislando luego el compuesto de la formula (I) y purificandolo. Tambien se revelan cepas nuevas de Mortierella maculata.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11845899P | 1999-02-03 | 1999-02-03 | |
US13475999P | 1999-05-18 | 1999-05-18 | |
PCT/US2000/002993 WO2000046175A1 (en) | 1999-02-03 | 2000-02-03 | Microbial process for preparing pravastatin |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA01007807A true MXPA01007807A (es) | 2003-06-04 |
Family
ID=26816384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA01007807A MXPA01007807A (es) | 1999-02-03 | 2000-02-03 | Proceso microbiano para preparar pravastatina. |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP1154979B1 (es) |
JP (2) | JP3645491B2 (es) |
KR (2) | KR100648541B1 (es) |
CN (3) | CN1177793C (es) |
AR (2) | AR023368A1 (es) |
AT (1) | ATE294771T1 (es) |
AU (2) | AU774438B2 (es) |
BG (1) | BG105778A (es) |
BR (1) | BR0009180A (es) |
CA (1) | CA2361701C (es) |
CZ (1) | CZ20012761A3 (es) |
DE (1) | DE60019898T2 (es) |
ES (1) | ES2240072T3 (es) |
HK (1) | HK1042686B (es) |
HR (1) | HRP20010577B1 (es) |
HU (1) | HUP0200650A3 (es) |
IL (1) | IL144697A0 (es) |
IS (1) | IS6036A (es) |
MX (1) | MXPA01007807A (es) |
NO (1) | NO20013818L (es) |
PL (1) | PL350317A1 (es) |
PT (1) | PT1154979E (es) |
RU (1) | RU2004127981A (es) |
SK (1) | SK10932001A3 (es) |
TR (2) | TR200600009T2 (es) |
WO (1) | WO2000046175A1 (es) |
YU (1) | YU55701A (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
EP1798214A3 (en) * | 1999-11-30 | 2007-08-01 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Process for recovering statin compounds from a fermentation broth |
AU1804601A (en) * | 1999-11-30 | 2001-06-12 | Biogal Gyogyszergyar Rt | Process for recovering statin compounds from a fermentation broth |
AU779306B2 (en) | 1999-12-14 | 2005-01-13 | Teva Gyogyszergyar Reszvenytarsasag | Novel forms of pravastatin sodium |
KR20030059173A (ko) * | 2000-10-05 | 2003-07-07 | 비오갈 기오기스제르갸르 알티. | 프라바스타틴 락톤과 에피-프라바스타틴을 실질적으로함유하지 않는 프라바스타틴 나트륨, 및 이를 포함하는조성물 |
JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
KR100540761B1 (ko) * | 2002-08-09 | 2006-01-16 | 코바이오텍 (주) | 프라바스타틴 나트륨의 제조방법 |
EP1452519A1 (en) * | 2003-02-25 | 2004-09-01 | Balkanpharma-Razgrad AD | Method for the isolation and purification of pravastatin sodium |
AU2004234235A1 (en) * | 2003-04-25 | 2004-11-11 | Nippon Chemiphar Co., Ltd. | Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid |
CN1244688C (zh) | 2003-07-09 | 2006-03-08 | 上海天伟生物制药有限公司 | 生产普伐他汀钠的微生物和方法 |
ES2251894T3 (es) | 2003-11-24 | 2009-04-01 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento de purificacion de pravastatina. |
TWI307360B (en) | 2004-12-03 | 2009-03-11 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Process for constructing strain having compactin hydroxylation ability |
ES2378614T3 (es) * | 2008-04-02 | 2012-04-16 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Extracción de pravastatina |
EP3714959A1 (en) * | 2019-03-29 | 2020-09-30 | Basf Se | Isolation of small molecules from the fermentation broth of a eukaryotic microorganism |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0906414T4 (en) * | 1996-03-28 | 2015-11-16 | Dsm Ip Assets Bv | PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE |
-
2000
- 2000-02-03 PL PL00350317A patent/PL350317A1/xx unknown
- 2000-02-03 PT PT00911709T patent/PT1154979E/pt unknown
- 2000-02-03 AU AU33567/00A patent/AU774438B2/en not_active Ceased
- 2000-02-03 YU YU55701A patent/YU55701A/sh unknown
- 2000-02-03 CN CNB008058792A patent/CN1177793C/zh not_active Expired - Fee Related
- 2000-02-03 KR KR1020017009821A patent/KR100648541B1/ko not_active IP Right Cessation
- 2000-02-03 KR KR1020067009407A patent/KR20060061406A/ko not_active Application Discontinuation
- 2000-02-03 HU HU0200650A patent/HUP0200650A3/hu unknown
- 2000-02-03 MX MXPA01007807A patent/MXPA01007807A/es unknown
- 2000-02-03 WO PCT/US2000/002993 patent/WO2000046175A1/en active IP Right Grant
- 2000-02-03 IL IL14469700A patent/IL144697A0/xx not_active IP Right Cessation
- 2000-02-03 JP JP2000597248A patent/JP3645491B2/ja not_active Expired - Fee Related
- 2000-02-03 BR BR0009180-4A patent/BR0009180A/pt not_active Application Discontinuation
- 2000-02-03 AT AT00911709T patent/ATE294771T1/de not_active IP Right Cessation
- 2000-02-03 SK SK1093-2001A patent/SK10932001A3/sk unknown
- 2000-02-03 CN CNA2004100456608A patent/CN1590363A/zh active Pending
- 2000-02-03 CA CA002361701A patent/CA2361701C/en not_active Expired - Fee Related
- 2000-02-03 TR TR2006/00009T patent/TR200600009T2/xx unknown
- 2000-02-03 CZ CZ20012761A patent/CZ20012761A3/cs unknown
- 2000-02-03 TR TR2001/03127T patent/TR200103127T2/xx unknown
- 2000-02-03 CN CNB2003101233833A patent/CN1260344C/zh not_active Expired - Fee Related
- 2000-02-03 ES ES00911709T patent/ES2240072T3/es not_active Expired - Lifetime
- 2000-02-03 DE DE60019898T patent/DE60019898T2/de not_active Expired - Fee Related
- 2000-02-03 EP EP00911709A patent/EP1154979B1/en not_active Expired - Lifetime
- 2000-02-04 AR ARP000100484A patent/AR023368A1/es unknown
-
2001
- 2001-07-31 HR HR20010577A patent/HRP20010577B1/xx not_active IP Right Cessation
- 2001-08-02 IS IS6036A patent/IS6036A/is unknown
- 2001-08-03 NO NO20013818A patent/NO20013818L/no not_active Application Discontinuation
- 2001-08-03 BG BG105778A patent/BG105778A/bg unknown
-
2002
- 2002-05-07 HK HK02103449.9A patent/HK1042686B/zh not_active IP Right Cessation
-
2004
- 2004-09-01 JP JP2004254575A patent/JP4197312B2/ja not_active Expired - Fee Related
- 2004-09-22 RU RU2004127981/04A patent/RU2004127981A/ru not_active Application Discontinuation
- 2004-09-24 AU AU2004214559A patent/AU2004214559A1/en not_active Abandoned
-
2007
- 2007-06-29 AR ARP070102941A patent/AR061765A2/es not_active Application Discontinuation
Also Published As
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