YU55701A - Mikrobiološki proces za pripremu prevastina - Google Patents

Mikrobiološki proces za pripremu prevastina

Info

Publication number
YU55701A
YU55701A YU55701A YUP55701A YU55701A YU 55701 A YU55701 A YU 55701A YU 55701 A YU55701 A YU 55701A YU P55701 A YUP55701 A YU P55701A YU 55701 A YU55701 A YU 55701A
Authority
YU
Yugoslavia
Prior art keywords
formula
compound
strain
hydroxylating
separating
Prior art date
Application number
YU55701A
Other languages
English (en)
Inventor
Antonia Jekkel
Attila Konya
Istvan Barta
Eva Ilkoy
Gyorgy Somogyi
Gabor Ambrus
Gyula Horvath
Karoly Albrecht
Istvan M. Szabo
Nee Suto Julianna Mozes
Janos Salat
Attila Andor
Laszlo Birincsik
Sandor Boros
Ildiko Lang
Nee Igloy Margit Bidlo
Original Assignee
Institute For Drug Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Research Ltd. filed Critical Institute For Drug Research Ltd.
Publication of YU55701A publication Critical patent/YU55701A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Predmetni pronalazak odnosi se na nove mikrobiološke procese za pripremanje jedinjenja formule (I) iz jedinjenja generalne formule (II) gde je R alkalni metal ili amonijum jon, pomoću potopljenog kultivisanja sluzavih gljiva soja sposobnog da 6Гџ-hidroksilira jedinjenje formule (II) u aerobnoj fermentaciji i razdvajanjem i prečišćavanjem produkta formule (I) nastalim tokom biokonverzije. Proces sadrži kultivisanje soja trepljaste vrste sluzavih gljiva Mortierella maculata koja je sposobna da 6Гџ-hidroksilira jedinjenje generalne formule (II), na hranjivom medijumu koji sadrži upotrebljive izvore ugljenika i azota i mineralnih soli i odvajanja produkta nastalog iz fermentacionog buljona, zatim izolovanja jedinjenja formule (I) i prečišćavanja istog. Takodje je otkriven novi soj Mortierella maculata.
YU55701A 1999-02-03 2000-02-03 Mikrobiološki proces za pripremu prevastina YU55701A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18

Publications (1)

Publication Number Publication Date
YU55701A true YU55701A (sh) 2004-07-15

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
YU55701A YU55701A (sh) 1999-02-03 2000-02-03 Mikrobiološki proces za pripremu prevastina

Country Status (27)

Country Link
EP (1) EP1154979B1 (sh)
JP (2) JP3645491B2 (sh)
KR (2) KR100648541B1 (sh)
CN (3) CN1177793C (sh)
AR (2) AR023368A1 (sh)
AT (1) ATE294771T1 (sh)
AU (2) AU774438B2 (sh)
BG (1) BG105778A (sh)
BR (1) BR0009180A (sh)
CA (1) CA2361701C (sh)
CZ (1) CZ20012761A3 (sh)
DE (1) DE60019898T2 (sh)
ES (1) ES2240072T3 (sh)
HK (1) HK1042686B (sh)
HR (1) HRP20010577B1 (sh)
HU (1) HUP0200650A3 (sh)
IL (1) IL144697A0 (sh)
IS (1) IS6036A (sh)
MX (1) MXPA01007807A (sh)
NO (1) NO20013818L (sh)
PL (1) PL350317A1 (sh)
PT (1) PT1154979E (sh)
RU (1) RU2004127981A (sh)
SK (1) SK10932001A3 (sh)
TR (2) TR200600009T2 (sh)
WO (1) WO2000046175A1 (sh)
YU (1) YU55701A (sh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
JP3881240B2 (ja) 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
EP1619190B1 (en) * 2003-04-25 2010-12-29 Nippon Chemiphar Co., Ltd. Salts of (2s,3s)-3- [[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl] oxirane-2-carboxylic acid
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
WO2009121870A1 (en) * 2008-04-02 2009-10-08 Dsm Ip Assets B.V. Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0906414T4 (en) * 1996-03-28 2015-11-16 Dsm Ip Assets Bv PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE

Also Published As

Publication number Publication date
KR20060061406A (ko) 2006-06-07
IS6036A (is) 2001-08-02
HRP20010577A2 (en) 2002-12-31
PT1154979E (pt) 2005-08-31
DE60019898T2 (de) 2006-08-10
AR023368A1 (es) 2002-09-04
HUP0200650A2 (en) 2002-08-28
DE60019898D1 (de) 2005-06-09
CN1347400A (zh) 2002-05-01
KR100648541B1 (ko) 2006-11-24
AR061765A2 (es) 2008-09-17
BR0009180A (pt) 2002-03-26
ES2240072T3 (es) 2005-10-16
MXPA01007807A (es) 2003-06-04
CA2361701A1 (en) 2000-08-10
CA2361701C (en) 2007-04-10
CN1537935A (zh) 2004-10-20
JP4197312B2 (ja) 2008-12-17
PL350317A1 (en) 2002-12-02
HK1042686A1 (en) 2002-08-23
KR20010112257A (ko) 2001-12-20
NO20013818D0 (no) 2001-08-03
JP2005047924A (ja) 2005-02-24
AU2004214559A1 (en) 2004-10-21
BG105778A (bg) 2002-05-31
CN1260344C (zh) 2006-06-21
CZ20012761A3 (cs) 2002-05-15
HRP20010577B1 (en) 2005-12-31
HK1042686B (zh) 2005-10-14
NO20013818L (no) 2001-10-03
RU2004127981A (ru) 2006-03-10
CN1177793C (zh) 2004-12-01
ATE294771T1 (de) 2005-05-15
TR200103127T2 (tr) 2002-04-22
CN1590363A (zh) 2005-03-09
JP3645491B2 (ja) 2005-05-11
TR200600009T2 (tr) 2006-08-21
EP1154979B1 (en) 2005-05-04
JP2002535977A (ja) 2002-10-29
HUP0200650A3 (en) 2008-03-28
SK10932001A3 (sk) 2002-06-04
WO2000046175A1 (en) 2000-08-10
EP1154979A1 (en) 2001-11-21
IL144697A0 (en) 2002-06-30
AU3356700A (en) 2000-08-25
AU774438B2 (en) 2004-06-24
EP1154979A4 (en) 2004-05-26

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