DE60019898D1 - Mikrobielles verfahren zur herstellung von pravastatin - Google Patents
Mikrobielles verfahren zur herstellung von pravastatinInfo
- Publication number
- DE60019898D1 DE60019898D1 DE60019898T DE60019898T DE60019898D1 DE 60019898 D1 DE60019898 D1 DE 60019898D1 DE 60019898 T DE60019898 T DE 60019898T DE 60019898 T DE60019898 T DE 60019898T DE 60019898 D1 DE60019898 D1 DE 60019898D1
- Authority
- DE
- Germany
- Prior art keywords
- microbial method
- preparing pravastatin
- pravastatin
- preparing
- microbial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title 1
- 230000000813 microbial effect Effects 0.000 title 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
- 229960002965 pravastatin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11845899P | 1999-02-03 | 1999-02-03 | |
| US118458P | 1999-02-03 | ||
| US13475999P | 1999-05-18 | 1999-05-18 | |
| US134759P | 1999-05-18 | ||
| PCT/US2000/002993 WO2000046175A1 (en) | 1999-02-03 | 2000-02-03 | Microbial process for preparing pravastatin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60019898D1 true DE60019898D1 (de) | 2005-06-09 |
| DE60019898T2 DE60019898T2 (de) | 2006-08-10 |
Family
ID=26816384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60019898T Expired - Fee Related DE60019898T2 (de) | 1999-02-03 | 2000-02-03 | Mikrobielles verfahren zur herstellung von pravastatin |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1154979B1 (de) |
| JP (2) | JP3645491B2 (de) |
| KR (2) | KR100648541B1 (de) |
| CN (3) | CN1177793C (de) |
| AR (2) | AR023368A1 (de) |
| AT (1) | ATE294771T1 (de) |
| AU (2) | AU774438B2 (de) |
| BG (1) | BG105778A (de) |
| BR (1) | BR0009180A (de) |
| CA (1) | CA2361701C (de) |
| CZ (1) | CZ20012761A3 (de) |
| DE (1) | DE60019898T2 (de) |
| ES (1) | ES2240072T3 (de) |
| HK (1) | HK1042686B (de) |
| HR (1) | HRP20010577B1 (de) |
| HU (1) | HUP0200650A3 (de) |
| IL (1) | IL144697A0 (de) |
| IS (1) | IS6036A (de) |
| MX (1) | MXPA01007807A (de) |
| NO (1) | NO20013818L (de) |
| PL (1) | PL350317A1 (de) |
| PT (1) | PT1154979E (de) |
| RU (1) | RU2004127981A (de) |
| SK (1) | SK10932001A3 (de) |
| TR (2) | TR200600009T2 (de) |
| WO (1) | WO2000046175A1 (de) |
| YU (1) | YU55701A (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI20305A (sl) † | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
| EP1798214A3 (de) * | 1999-11-30 | 2007-08-01 | Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság | Verfahren zur Gewinnung von Statinverbindungen aus einer Fermentationsbrühe |
| JP3881240B2 (ja) | 1999-11-30 | 2007-02-14 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 醗酵ブロスからスタチン化合物を回収するための方法 |
| AU779306B2 (en) | 1999-12-14 | 2005-01-13 | Teva Gyogyszergyar Reszvenytarsasag | Novel forms of pravastatin sodium |
| CN1468098A (zh) * | 2000-10-05 | 2004-01-14 | �ݰ¸Ƕ�ҩ������˾ | 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物 |
| JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
| KR100540761B1 (ko) * | 2002-08-09 | 2006-01-16 | 코바이오텍 (주) | 프라바스타틴 나트륨의 제조방법 |
| EP1452519A1 (de) * | 2003-02-25 | 2004-09-01 | Balkanpharma-Razgrad AD | Verfahren zur Isolierung und Reinigung von Pravastatin-Natriumsalz |
| EP1619190B1 (de) * | 2003-04-25 | 2010-12-29 | Nippon Chemiphar Co., Ltd. | Salze von (2s,3s)-3- [[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl] oxirane-2-carbonsäure |
| CN1244688C (zh) | 2003-07-09 | 2006-03-08 | 上海天伟生物制药有限公司 | 生产普伐他汀钠的微生物和方法 |
| WO2005051372A2 (en) | 2003-11-24 | 2005-06-09 | Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság | Method of purifying pravastatin |
| TWI307360B (en) | 2004-12-03 | 2009-03-11 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Process for constructing strain having compactin hydroxylation ability |
| WO2009121870A1 (en) * | 2008-04-02 | 2009-10-08 | Dsm Ip Assets B.V. | Pravastatin extraction |
| EP3714959A1 (de) * | 2019-03-29 | 2020-09-30 | Basf Se | Isolierung von kleinen molekülen aus der fermentationsbrühe eines eukaryotischen mikroorganismus |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0906414T4 (en) * | 1996-03-28 | 2015-11-16 | Dsm Ip Assets Bv | PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE |
-
2000
- 2000-02-03 MX MXPA01007807A patent/MXPA01007807A/es unknown
- 2000-02-03 JP JP2000597248A patent/JP3645491B2/ja not_active Expired - Fee Related
- 2000-02-03 YU YU55701A patent/YU55701A/sh unknown
- 2000-02-03 CN CNB008058792A patent/CN1177793C/zh not_active Expired - Fee Related
- 2000-02-03 AU AU33567/00A patent/AU774438B2/en not_active Ceased
- 2000-02-03 TR TR2006/00009T patent/TR200600009T2/xx unknown
- 2000-02-03 IL IL14469700A patent/IL144697A0/xx not_active IP Right Cessation
- 2000-02-03 CZ CZ20012761A patent/CZ20012761A3/cs unknown
- 2000-02-03 PL PL00350317A patent/PL350317A1/xx unknown
- 2000-02-03 SK SK1093-2001A patent/SK10932001A3/sk unknown
- 2000-02-03 DE DE60019898T patent/DE60019898T2/de not_active Expired - Fee Related
- 2000-02-03 PT PT00911709T patent/PT1154979E/pt unknown
- 2000-02-03 CA CA002361701A patent/CA2361701C/en not_active Expired - Fee Related
- 2000-02-03 TR TR2001/03127T patent/TR200103127T2/xx unknown
- 2000-02-03 KR KR1020017009821A patent/KR100648541B1/ko not_active IP Right Cessation
- 2000-02-03 EP EP00911709A patent/EP1154979B1/de not_active Expired - Lifetime
- 2000-02-03 AT AT00911709T patent/ATE294771T1/de not_active IP Right Cessation
- 2000-02-03 BR BR0009180-4A patent/BR0009180A/pt not_active Application Discontinuation
- 2000-02-03 WO PCT/US2000/002993 patent/WO2000046175A1/en active IP Right Grant
- 2000-02-03 ES ES00911709T patent/ES2240072T3/es not_active Expired - Lifetime
- 2000-02-03 HU HU0200650A patent/HUP0200650A3/hu unknown
- 2000-02-03 CN CNA2004100456608A patent/CN1590363A/zh active Pending
- 2000-02-03 KR KR1020067009407A patent/KR20060061406A/ko not_active Application Discontinuation
- 2000-02-03 CN CNB2003101233833A patent/CN1260344C/zh not_active Expired - Fee Related
- 2000-02-04 AR ARP000100484A patent/AR023368A1/es unknown
-
2001
- 2001-07-31 HR HR20010577A patent/HRP20010577B1/xx not_active IP Right Cessation
- 2001-08-02 IS IS6036A patent/IS6036A/is unknown
- 2001-08-03 NO NO20013818A patent/NO20013818L/no not_active Application Discontinuation
- 2001-08-03 BG BG105778A patent/BG105778A/bg unknown
-
2002
- 2002-05-07 HK HK02103449.9A patent/HK1042686B/zh not_active IP Right Cessation
-
2004
- 2004-09-01 JP JP2004254575A patent/JP4197312B2/ja not_active Expired - Fee Related
- 2004-09-22 RU RU2004127981/04A patent/RU2004127981A/ru not_active Application Discontinuation
- 2004-09-24 AU AU2004214559A patent/AU2004214559A1/en not_active Abandoned
-
2007
- 2007-06-29 AR ARP070102941A patent/AR061765A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |