DE60023859D1 - Verfahren zur herstellung von amin-platin-komplexen - Google Patents

Verfahren zur herstellung von amin-platin-komplexen

Info

Publication number
DE60023859D1
DE60023859D1 DE60023859T DE60023859T DE60023859D1 DE 60023859 D1 DE60023859 D1 DE 60023859D1 DE 60023859 T DE60023859 T DE 60023859T DE 60023859 T DE60023859 T DE 60023859T DE 60023859 D1 DE60023859 D1 DE 60023859D1
Authority
DE
Germany
Prior art keywords
amin
producing
platinum complexes
complexes
platinum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60023859T
Other languages
English (en)
Other versions
DE60023859T2 (de
Inventor
S Wong
M Giandomenico
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Publication of DE60023859D1 publication Critical patent/DE60023859D1/de
Application granted granted Critical
Publication of DE60023859T2 publication Critical patent/DE60023859T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
DE60023859T 1999-04-13 2000-04-11 Verfahren zur herstellung von amin-platin-komplexen Expired - Lifetime DE60023859T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12893999P 1999-04-13 1999-04-13
US128939P 1999-04-13
PCT/CA2000/000385 WO2000061590A1 (en) 1999-04-13 2000-04-11 Process for preparing amine platinum complexes

Publications (2)

Publication Number Publication Date
DE60023859D1 true DE60023859D1 (de) 2005-12-15
DE60023859T2 DE60023859T2 (de) 2006-08-03

Family

ID=22437722

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60023859T Expired - Lifetime DE60023859T2 (de) 1999-04-13 2000-04-11 Verfahren zur herstellung von amin-platin-komplexen

Country Status (32)

Country Link
US (1) US6518428B1 (de)
EP (1) EP1165576B1 (de)
JP (1) JP4756669B2 (de)
KR (1) KR100711955B1 (de)
CN (3) CN1250559C (de)
AR (1) AR043084A1 (de)
AT (1) ATE309257T1 (de)
AU (1) AU770006B2 (de)
BG (1) BG65429B1 (de)
BR (1) BR0009780B1 (de)
CA (1) CA2368849C (de)
CY (1) CY1104965T1 (de)
CZ (1) CZ303156B6 (de)
DE (1) DE60023859T2 (de)
DK (1) DK1165576T3 (de)
EE (1) EE04747B1 (de)
ES (1) ES2253214T3 (de)
HK (2) HK1039336B (de)
HU (1) HUP0200748A3 (de)
IL (1) IL145671A0 (de)
IS (1) IS2711B3 (de)
MX (1) MXPA01010430A (de)
MY (1) MY122706A (de)
NO (1) NO330429B1 (de)
NZ (1) NZ514736A (de)
PL (1) PL202731B1 (de)
RU (1) RU2245340C2 (de)
SK (1) SK286374B6 (de)
TW (1) TWI289565B (de)
UA (1) UA71614C2 (de)
WO (1) WO2000061590A1 (de)
ZA (1) ZA200107965B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US6413953B1 (en) * 1999-04-13 2002-07-02 Anormed Inc. Pt(IV) antitumor agent
RU2245340C2 (ru) 1999-04-13 2005-01-27 Анормед, Инк. Цисплатиновый комплекс и способ его получения
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6806289B1 (en) * 2000-07-14 2004-10-19 Stephen J. Lippard Coordination complexes, and methods for preparing by combinatorial methods, assaying and using the same
US6894049B1 (en) 2000-10-04 2005-05-17 Anormed, Inc. Platinum complexes as antitumor agents
PT1720540E (pt) 2004-02-18 2008-09-10 Gpc Biotech Ag Métodos de tratamento de tumores resistentes ou refractários
CZ2004964A3 (cs) * 2004-09-14 2006-03-15 Pliva-Lachema A. S. Perorální farmaceutická kompozice pro cílený transport komplexu platiny do kolorektální oblasti, zpusob její prípravy a tato kompozice pro pouzití jako lécivo
ES2257178B1 (es) * 2004-09-30 2007-08-16 Universidad Autonoma De Madrid Compuestos de platino de formula trans-(ptc12(isopropilamina)(4-(hidroximetil)-piridina)) y trans-(ptc12(isopropilamina)(3-hidroximetil)-piridina y su aplicacion como farmaco antitumoral.
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
EP2178893A4 (de) * 2007-07-16 2012-09-19 Poniard Pharmaceuticals Inc Orale formulierungen für picoplatin
AU2009210654A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and bevacizumab to treat colorectal cancer
WO2010144827A1 (en) * 2009-06-12 2010-12-16 Poniard Pharmaceuticals, Inc. Improved synthesis of picoplatin
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
CN105254679B (zh) * 2013-11-19 2018-05-15 辽宁大学 单6-(氮杂环取代)蒽醌二氯化铂配合物及其制备方法和应用
CN103860539B (zh) * 2014-04-14 2016-02-10 于迎涛 一种具有混合轴向配体的Pt（IV）类抗癌药物及制备方法
CN104231000A (zh) * 2014-08-20 2014-12-24 山东铂源药业有限公司 一种抗肿瘤药物甲啶铂的合成方法
US10987353B2 (en) 2016-05-04 2021-04-27 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs
KR102137669B1 (ko) * 2019-08-05 2020-07-27 한국과학기술연구원 메탄올 또는 그 전구체 합성용 촉매, 이의 제조방법 및 이를 이용한 메탄올 또는 그 전구체의 제조방법
WO2022008149A1 (en) 2020-07-08 2022-01-13 Dayton Therapeutics Ag Satraplatin for use in the treatment of lymphoid neoplasms
CN113402565B (zh) * 2021-06-16 2023-07-28 中国人民解放军空军军医大学 一类含有泊沙康唑的四价铂配合物、制备方法及其应用
WO2023131524A1 (en) 2022-01-07 2023-07-13 Dayton Therapeutics Ag Treating haematological malignancies by means of satraplatin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2060615B (en) 1979-08-23 1983-06-22 Johnson Matthey Co Ltd Platinum-amine complexes
US4533502A (en) 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
EP0167310B1 (de) * 1984-06-27 1991-05-29 Johnson Matthey Public Limited Company Platinkoordinationsverbindungen
US5244919A (en) 1988-02-02 1993-09-14 Johnson Matthey, Inc. Pt(IV) complexes as anti-tumor agents
GB9105037D0 (en) 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US5547982A (en) 1995-02-27 1996-08-20 Johnson Matthey, Inc. Anti-tumor platinum complexes
JP2004500321A (ja) 1999-03-19 2004-01-08 アノーメッド　インコーポレイティド 金属錯体を含む薬学的組成物
RU2245340C2 (ru) 1999-04-13 2005-01-27 Анормед, Инк. Цисплатиновый комплекс и способ его получения

Also Published As

Publication number Publication date
IS6092A (is) 2001-09-28
AU770006B2 (en) 2004-02-12
CN100460412C (zh) 2009-02-11
ZA200107965B (en) 2003-01-02
CZ303156B6 (cs) 2012-05-09
NO330429B1 (no) 2011-04-11
UA71614C2 (en) 2004-12-15
US6518428B1 (en) 2003-02-11
AR043084A1 (es) 2005-07-20
CY1104965T1 (el) 2010-03-03
SK14682001A3 (sk) 2002-01-07
CZ20013648A3 (cs) 2002-02-13
EP1165576B1 (de) 2005-11-09
DK1165576T3 (da) 2006-03-27
SK286374B6 (sk) 2008-08-05
CN1847253A (zh) 2006-10-18
EP1165576A1 (de) 2002-01-02
BG106090A (en) 2002-06-28
ATE309257T1 (de) 2005-11-15
HUP0200748A3 (en) 2010-01-28
PL351612A1 (en) 2003-05-05
CA2368849C (en) 2011-01-25
CN1916009A (zh) 2007-02-21
EE200100536A (et) 2003-02-17
PL202731B1 (pl) 2009-07-31
HK1039336B (zh) 2006-01-27
MXPA01010430A (es) 2002-03-27
HK1039336A1 (en) 2002-04-19
WO2000061590A1 (en) 2000-10-19
IS2709B (is) 2011-01-15
BG65429B1 (bg) 2008-07-31
HK1100562A1 (en) 2007-09-21
AU3951000A (en) 2000-11-14
KR20020018189A (ko) 2002-03-07
JP2002541263A (ja) 2002-12-03
HUP0200748A2 (hu) 2002-07-29
CN1250559C (zh) 2006-04-12
NO20014957D0 (no) 2001-10-12
TWI289565B (en) 2007-11-11
NZ514736A (en) 2004-01-30
MY122706A (en) 2006-04-29
BR0009780B1 (pt) 2013-09-24
KR100711955B1 (ko) 2007-05-02
CN1916009B (zh) 2010-12-15
RU2245340C2 (ru) 2005-01-27
NO20014957L (no) 2001-12-03
JP4756669B2 (ja) 2011-08-24
EE04747B1 (et) 2006-12-15
ES2253214T3 (es) 2006-06-01
DE60023859T2 (de) 2006-08-03
CA2368849A1 (en) 2000-10-19
IL145671A0 (en) 2002-06-30
CN1350540A (zh) 2002-05-22
IS2711B3 (is) 2011-01-15
BR0009780A (pt) 2002-01-02

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Legal Events

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