HRP20010577B1 - Microbial process for preparing pravastatin - Google Patents

Microbial process for preparing pravastatin

Info

Publication number
HRP20010577B1
HRP20010577B1 HR20010577A HRP20010577A HRP20010577B1 HR P20010577 B1 HRP20010577 B1 HR P20010577B1 HR 20010577 A HR20010577 A HR 20010577A HR P20010577 A HRP20010577 A HR P20010577A HR P20010577 B1 HRP20010577 B1 HR P20010577B1
Authority
HR
Croatia
Prior art keywords
microbial process
preparing pravastatin
pravastatin
preparing
microbial
Prior art date
Application number
HR20010577A
Inventor
Albrecht Karoly
Ambrus Gabor
Andor Attila
Barta Istvan
Bidlo Nee Igloy Margit
Birincsik Laszlo
Boros Sandor
Ilkoy Eva
Konya Attila
Mozes Nee Suto Julliana
Somogyi Gyorgy
Horvath Gyula
Jekkel Antonia
Lang Ildiko
Salat Janos
M. Szabo Istvan
Original Assignee
Institute For Drug Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Research Ltd. filed Critical Institute For Drug Research Ltd.
Publication of HRP20010577A2 publication Critical patent/HRP20010577A2/en
Publication of HRP20010577B1 publication Critical patent/HRP20010577B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20010577A 1999-02-03 2001-07-31 Microbial process for preparing pravastatin HRP20010577B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Publications (2)

Publication Number Publication Date
HRP20010577A2 HRP20010577A2 (en) 2002-12-31
HRP20010577B1 true HRP20010577B1 (en) 2005-12-31

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010577A HRP20010577B1 (en) 1999-02-03 2001-07-31 Microbial process for preparing pravastatin

Country Status (27)

Country Link
EP (1) EP1154979B1 (en)
JP (2) JP3645491B2 (en)
KR (2) KR100648541B1 (en)
CN (3) CN1177793C (en)
AR (2) AR023368A1 (en)
AT (1) ATE294771T1 (en)
AU (2) AU774438B2 (en)
BG (1) BG105778A (en)
BR (1) BR0009180A (en)
CA (1) CA2361701C (en)
CZ (1) CZ20012761A3 (en)
DE (1) DE60019898T2 (en)
ES (1) ES2240072T3 (en)
HK (1) HK1042686B (en)
HR (1) HRP20010577B1 (en)
HU (1) HUP0200650A3 (en)
IL (1) IL144697A0 (en)
IS (1) IS6036A (en)
MX (1) MXPA01007807A (en)
NO (1) NO20013818L (en)
PL (1) PL350317A1 (en)
PT (1) PT1154979E (en)
RU (1) RU2004127981A (en)
SK (1) SK10932001A3 (en)
TR (2) TR200600009T2 (en)
WO (1) WO2000046175A1 (en)
YU (1) YU55701A (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (en) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Pravastatin sodium salt crystals
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
JP3881240B2 (en) 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ Method for recovering statin compounds from fermentation broth
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
CN1468098A (en) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (en) * 2001-07-17 2003-01-29 Mercian Corp Method for producing pravastatin sodium salt
KR100540761B1 (en) * 2002-08-09 2006-01-16 코바이오텍 (주) Method for preparing sodium salt of pravastatin
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
EP1619190B1 (en) * 2003-04-25 2010-12-29 Nippon Chemiphar Co., Ltd. Salts of (2s,3s)-3- [[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl] oxirane-2-carboxylic acid
CN1244688C (en) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 Microbe and process for preparing pravastatin sodium
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
WO2009121870A1 (en) * 2008-04-02 2009-10-08 Dsm Ip Assets B.V. Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0906414T4 (en) * 1996-03-28 2015-11-16 Dsm Ip Assets Bv PROCESS FOR THE PREPARATION OF A granular MICROBIAL BIOMASS AND ISOLATION OF VALUABLE COMPOUNDS THENCE

Also Published As

Publication number Publication date
KR20060061406A (en) 2006-06-07
IS6036A (en) 2001-08-02
HRP20010577A2 (en) 2002-12-31
PT1154979E (en) 2005-08-31
DE60019898T2 (en) 2006-08-10
YU55701A (en) 2004-07-15
AR023368A1 (en) 2002-09-04
HUP0200650A2 (en) 2002-08-28
DE60019898D1 (en) 2005-06-09
CN1347400A (en) 2002-05-01
KR100648541B1 (en) 2006-11-24
AR061765A2 (en) 2008-09-17
BR0009180A (en) 2002-03-26
ES2240072T3 (en) 2005-10-16
MXPA01007807A (en) 2003-06-04
CA2361701A1 (en) 2000-08-10
CA2361701C (en) 2007-04-10
CN1537935A (en) 2004-10-20
JP4197312B2 (en) 2008-12-17
PL350317A1 (en) 2002-12-02
HK1042686A1 (en) 2002-08-23
KR20010112257A (en) 2001-12-20
NO20013818D0 (en) 2001-08-03
JP2005047924A (en) 2005-02-24
AU2004214559A1 (en) 2004-10-21
BG105778A (en) 2002-05-31
CN1260344C (en) 2006-06-21
CZ20012761A3 (en) 2002-05-15
HK1042686B (en) 2005-10-14
NO20013818L (en) 2001-10-03
RU2004127981A (en) 2006-03-10
CN1177793C (en) 2004-12-01
ATE294771T1 (en) 2005-05-15
TR200103127T2 (en) 2002-04-22
CN1590363A (en) 2005-03-09
JP3645491B2 (en) 2005-05-11
TR200600009T2 (en) 2006-08-21
EP1154979B1 (en) 2005-05-04
JP2002535977A (en) 2002-10-29
HUP0200650A3 (en) 2008-03-28
SK10932001A3 (en) 2002-06-04
WO2000046175A1 (en) 2000-08-10
EP1154979A1 (en) 2001-11-21
IL144697A0 (en) 2002-06-30
AU3356700A (en) 2000-08-25
AU774438B2 (en) 2004-06-24
EP1154979A4 (en) 2004-05-26

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20070125

Year of fee payment: 8

PBON Lapse due to non-payment of renewal fee

Effective date: 20080204