BR0009180A - Processo microbiológico para a preparação de pravastatin - Google Patents

Processo microbiológico para a preparação de pravastatin

Info

Publication number
BR0009180A
BR0009180A BR0009180-4A BR0009180A BR0009180A BR 0009180 A BR0009180 A BR 0009180A BR 0009180 A BR0009180 A BR 0009180A BR 0009180 A BR0009180 A BR 0009180A
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation
hydroxylating
product formed
Prior art date
Application number
BR0009180-4A
Other languages
English (en)
Inventor
Antonia Jekkel
Istvan Barta
Ildiko Lang
Margit Bidlo
Janos Salat
Karoly Albrecht
Julianna Mozes
Istvan M Szabo
Eva Ilkoy
Gyorgy Somogyi
Gabor Ambrus
Gyula Horvath
Attila Andor
Laszlo Birincsik
Sandor Boros
Attila Konya
Original Assignee
Inst Drug Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Drug Res Ltd filed Critical Inst Drug Res Ltd
Publication of BR0009180A publication Critical patent/BR0009180A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO MICROBIAL PARA A PREPARAçãO DE PRAVASTATIN". A presente invenção refere-se a um processo microbial para a preparação do composto da fórmula (I) a partir de uma fórmula de composto geral (II) na qual R significa um metal alcalino ou íon de amónia, pelo cultivo submerso de um grupo matriz capaz de 6<225>-hidroxilar um composto de Fórmula (II) em fermentação aeróbica e pela separação e purificação do produto da Fórmula (I) formado no curso da bioconversão. O processo consiste em cultivar um grupo de espécie matriz filamentosa de Mortierella maculata que seja capaz de 6<225>-hidroxilar um composto de Fórmula (II) geral em um meio nutriente que contém carbono e fontes de nitrogênio assimiláveis e sais minerais e separar o produto formado a partir do fluido de fermentação e, em seguida, isolar o composto da fórmula (I) e purifica-lo. Novos grupos de Mortierella maculata também são divulgados.
BR0009180-4A 1999-02-03 2000-02-03 Processo microbiológico para a preparação de pravastatin BR0009180A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Publications (1)

Publication Number Publication Date
BR0009180A true BR0009180A (pt) 2002-03-26

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009180-4A BR0009180A (pt) 1999-02-03 2000-02-03 Processo microbiológico para a preparação de pravastatin

Country Status (27)

Country Link
EP (1) EP1154979B1 (pt)
JP (2) JP3645491B2 (pt)
KR (2) KR100648541B1 (pt)
CN (3) CN1260344C (pt)
AR (2) AR023368A1 (pt)
AT (1) ATE294771T1 (pt)
AU (2) AU774438B2 (pt)
BG (1) BG105778A (pt)
BR (1) BR0009180A (pt)
CA (1) CA2361701C (pt)
CZ (1) CZ20012761A3 (pt)
DE (1) DE60019898T2 (pt)
ES (1) ES2240072T3 (pt)
HK (1) HK1042686B (pt)
HR (1) HRP20010577B1 (pt)
HU (1) HUP0200650A3 (pt)
IL (1) IL144697A0 (pt)
IS (1) IS6036A (pt)
MX (1) MXPA01007807A (pt)
NO (1) NO20013818L (pt)
PL (1) PL350317A1 (pt)
PT (1) PT1154979E (pt)
RU (1) RU2004127981A (pt)
SK (1) SK10932001A3 (pt)
TR (2) TR200600009T2 (pt)
WO (1) WO2000046175A1 (pt)
YU (1) YU55701A (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
PT1265604E (pt) * 1999-11-30 2006-12-29 Teva Gyogyszergyar Zartkoeruen Processo para a recuperação de compostos de estatina de um caldo de fermentação
IL150187A0 (en) 1999-12-14 2002-12-01 Biogal Pharmaceutical Co Ltd Novel forms of pravastatin sodium
CZ20031166A3 (cs) * 2000-10-05 2004-04-14 Biogal Gyogyszergyar Rt Sodná sůl pravastatinu, která v podstatě neobsahuje pravastatin lakton a epi-pravastatin a kompozice na její bázi
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
CN100506811C (zh) * 2003-04-25 2009-07-01 日本化学医药株式会社 (2s,3s)-3-[[(1s)-1-异丁氧基甲基-3-甲基丁基]氨基甲酰基]环氧乙烷-2-甲酸盐
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
ATE412409T1 (de) 2003-11-24 2008-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur reinigung von pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
EP2274267B1 (en) * 2008-04-02 2012-01-04 DSM IP Assets B.V. Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1715394A (zh) * 1996-03-28 2006-01-04 吉斯特-布罗卡迪斯股份有限公司 粒状微生物生物质的制备及其有价值的化合物的分离方法

Also Published As

Publication number Publication date
PL350317A1 (en) 2002-12-02
SK10932001A3 (sk) 2002-06-04
ES2240072T3 (es) 2005-10-16
CA2361701C (en) 2007-04-10
CN1260344C (zh) 2006-06-21
KR20060061406A (ko) 2006-06-07
DE60019898T2 (de) 2006-08-10
JP4197312B2 (ja) 2008-12-17
NO20013818D0 (no) 2001-08-03
AR061765A2 (es) 2008-09-17
EP1154979B1 (en) 2005-05-04
WO2000046175A1 (en) 2000-08-10
JP2005047924A (ja) 2005-02-24
TR200103127T2 (tr) 2002-04-22
CA2361701A1 (en) 2000-08-10
HRP20010577B1 (en) 2005-12-31
DE60019898D1 (de) 2005-06-09
JP3645491B2 (ja) 2005-05-11
HK1042686B (zh) 2005-10-14
TR200600009T2 (tr) 2006-08-21
EP1154979A1 (en) 2001-11-21
AR023368A1 (es) 2002-09-04
HRP20010577A2 (en) 2002-12-31
RU2004127981A (ru) 2006-03-10
ATE294771T1 (de) 2005-05-15
HK1042686A1 (en) 2002-08-23
KR100648541B1 (ko) 2006-11-24
CN1177793C (zh) 2004-12-01
MXPA01007807A (es) 2003-06-04
PT1154979E (pt) 2005-08-31
BG105778A (bg) 2002-05-31
HUP0200650A2 (en) 2002-08-28
AU2004214559A1 (en) 2004-10-21
NO20013818L (no) 2001-10-03
CZ20012761A3 (cs) 2002-05-15
YU55701A (sh) 2004-07-15
JP2002535977A (ja) 2002-10-29
AU774438B2 (en) 2004-06-24
CN1590363A (zh) 2005-03-09
KR20010112257A (ko) 2001-12-20
CN1537935A (zh) 2004-10-20
AU3356700A (en) 2000-08-25
HUP0200650A3 (en) 2008-03-28
IL144697A0 (en) 2002-06-30
IS6036A (is) 2001-08-02
CN1347400A (zh) 2002-05-01
EP1154979A4 (en) 2004-05-26

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Legal Events

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B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 10 (IX) DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

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