DE60007338D1 - Verfahren zur herstellung von mycophenolsäure und derivaten davon - Google Patents
Verfahren zur herstellung von mycophenolsäure und derivaten davonInfo
- Publication number
- DE60007338D1 DE60007338D1 DE60007338T DE60007338T DE60007338D1 DE 60007338 D1 DE60007338 D1 DE 60007338D1 DE 60007338 T DE60007338 T DE 60007338T DE 60007338 T DE60007338 T DE 60007338T DE 60007338 D1 DE60007338 D1 DE 60007338D1
- Authority
- DE
- Germany
- Prior art keywords
- general formula
- stands
- compound
- group
- streptomyces
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 title abstract 2
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 title abstract 2
- 229960000951 mycophenolic acid Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241001446247 uncultured actinomycete Species 0.000 abstract 2
- 241000985504 Penicillium waksmanii Species 0.000 abstract 1
- 241000187217 Streptomyces griseoruber Species 0.000 abstract 1
- 241000946782 Streptomyces resistomycificus Species 0.000 abstract 1
- 241000187180 Streptomyces sp. Species 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9903226A HUP9903226A2 (en) | 1999-09-23 | 1999-09-23 | Process for producing mycophenolic acid and derivatives thereof |
| HU9903226 | 1999-09-23 | ||
| PCT/HU2000/000099 WO2001021607A2 (en) | 1999-09-23 | 2000-09-22 | Process for the preparation of mycophenolic acid and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60007338D1 true DE60007338D1 (de) | 2004-01-29 |
| DE60007338T2 DE60007338T2 (de) | 2004-11-11 |
Family
ID=89999424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60007338T Expired - Fee Related DE60007338T2 (de) | 1999-09-23 | 2000-09-22 | Verfahren zur herstellung von mycophenolsäure und derivaten davon |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1216237B1 (de) |
| JP (1) | JP3854866B2 (de) |
| KR (1) | KR20020060184A (de) |
| AT (1) | ATE256674T1 (de) |
| AU (1) | AU768773B2 (de) |
| CA (1) | CA2385317A1 (de) |
| DE (1) | DE60007338T2 (de) |
| DK (1) | DK1216237T3 (de) |
| ES (1) | ES2211620T3 (de) |
| HU (1) | HUP9903226A2 (de) |
| PT (1) | PT1216237E (de) |
| WO (1) | WO2001021607A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0124953D0 (en) * | 2001-10-17 | 2001-12-05 | Novartis Ag | Organic Compounds |
| AU2002313587A1 (en) * | 2002-06-18 | 2003-12-31 | Biocon Limited | Fed batch solid state fermentation for the production of mycophenolic acid |
| WO2004087938A1 (ja) * | 2003-03-31 | 2004-10-14 | Meiji Seika Kaisha, Ltd. | 新規生理活性物質ｐｆ１２７０ａ、ｂおよびｃ物質 |
| JP2007532585A (ja) * | 2004-04-26 | 2007-11-15 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ミコフェノール酸及びそのエステル誘導体の調製方法 |
| EP1740563A2 (de) | 2004-04-27 | 2007-01-10 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Mykophenolatmofetilverunreinigung |
| WO2006012379A2 (en) | 2004-07-20 | 2006-02-02 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Processes for preparation of crystalline mycophenolate sodium |
| EP1624070A1 (de) * | 2004-08-05 | 2006-02-08 | Tecnimede-Sociedade Tecnico-Medicinal, S.A. | Verfahren zur Herstellung von Mycophenolsäure |
| WO2008003637A2 (en) * | 2006-07-05 | 2008-01-10 | Dsm Ip Assets B.V. | Isolation and use of amine salts of mycophenolic acid |
| US20110166347A1 (en) * | 2008-09-10 | 2011-07-07 | Ipca Laboratories Ltd. | Process for preparation of mycophenolic acid, its salt and ester derivatives |
| US9376415B2 (en) | 2009-03-30 | 2016-06-28 | Nippon Suisan Kaisha, Ltd. | Tricyclic condensed heterocyclic compound, process of producing same, and use thereof |
| CN103641809B (zh) * | 2013-11-23 | 2016-04-13 | 浙江师范大学 | 新月旋孢酸类化合物c及其制法和用途 |
| CN109929890B (zh) * | 2019-05-08 | 2020-12-04 | 广东蓝宝制药有限公司 | 一种麦考酚酸的发酵工艺 |
| CN113717888B (zh) * | 2021-08-30 | 2023-03-24 | 中国热带农业科学院海口实验站 | 一种新链霉菌及其应用 |
-
1999
- 1999-09-23 HU HU9903226A patent/HUP9903226A2/hu unknown
-
2000
- 2000-09-22 CA CA002385317A patent/CA2385317A1/en not_active Abandoned
- 2000-09-22 PT PT00966338T patent/PT1216237E/pt unknown
- 2000-09-22 DK DK00966338T patent/DK1216237T3/da active
- 2000-09-22 ES ES00966338T patent/ES2211620T3/es not_active Expired - Lifetime
- 2000-09-22 JP JP2001524986A patent/JP3854866B2/ja not_active Expired - Fee Related
- 2000-09-22 DE DE60007338T patent/DE60007338T2/de not_active Expired - Fee Related
- 2000-09-22 AU AU76776/00A patent/AU768773B2/en not_active Ceased
- 2000-09-22 WO PCT/HU2000/000099 patent/WO2001021607A2/en not_active Application Discontinuation
- 2000-09-22 AT AT00966338T patent/ATE256674T1/de not_active IP Right Cessation
- 2000-09-22 EP EP00966338A patent/EP1216237B1/de not_active Expired - Lifetime
- 2000-09-22 KR KR1020027003830A patent/KR20020060184A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9903226D0 (en) | 1999-11-29 |
| WO2001021607A3 (en) | 2001-09-07 |
| AU7677600A (en) | 2001-04-24 |
| JP3854866B2 (ja) | 2006-12-06 |
| JP2003509508A (ja) | 2003-03-11 |
| DK1216237T3 (da) | 2004-04-19 |
| WO2001021607A2 (en) | 2001-03-29 |
| CA2385317A1 (en) | 2001-03-29 |
| ATE256674T1 (de) | 2004-01-15 |
| PT1216237E (pt) | 2004-04-30 |
| EP1216237A2 (de) | 2002-06-26 |
| KR20020060184A (ko) | 2002-07-16 |
| DE60007338T2 (de) | 2004-11-11 |
| HUP9903226A2 (en) | 2002-08-28 |
| EP1216237B1 (de) | 2003-12-17 |
| AU768773B2 (en) | 2004-01-08 |
| ES2211620T3 (es) | 2004-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |