BG105778A - Микробиален метод за получаване на правастатин - Google Patents

Микробиален метод за получаване на правастатин Download PDF

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Publication number
BG105778A
BG105778A BG105778A BG10577801A BG105778A BG 105778 A BG105778 A BG 105778A BG 105778 A BG105778 A BG 105778A BG 10577801 A BG10577801 A BG 10577801A BG 105778 A BG105778 A BG 105778A
Authority
BG
Bulgaria
Prior art keywords
compound
formula
pravastatin
broth
strain
Prior art date
Application number
BG105778A
Other languages
Bulgarian (bg)
English (en)
Inventor
Antonia Jekkel
Attila Konya
Istvan Barta
Eva Ilkoy
Gyorgy Somogyi
Gabor Ambrus
Gyula Horvath
Karoly Albrecht
Istvan Szabo
Juliana SUTO
Janos Salat
Attila Andor
Laszlo Birincsik
Sandor Boros
Ildiko Lang
Nee Igloy Margit Bidlo
Original Assignee
Institute For Drug Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Research Ltd. filed Critical Institute For Drug Research Ltd.
Publication of BG105778A publication Critical patent/BG105778A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG105778A 1999-02-03 2001-08-03 Микробиален метод за получаване на правастатин BG105778A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US13475999P 1999-05-18 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Publications (1)

Publication Number Publication Date
BG105778A true BG105778A (bg) 2002-05-31

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105778A BG105778A (bg) 1999-02-03 2001-08-03 Микробиален метод за получаване на правастатин

Country Status (27)

Country Link
EP (1) EP1154979B1 (es)
JP (2) JP3645491B2 (es)
KR (2) KR100648541B1 (es)
CN (3) CN1177793C (es)
AR (2) AR023368A1 (es)
AT (1) ATE294771T1 (es)
AU (2) AU774438B2 (es)
BG (1) BG105778A (es)
BR (1) BR0009180A (es)
CA (1) CA2361701C (es)
CZ (1) CZ20012761A3 (es)
DE (1) DE60019898T2 (es)
ES (1) ES2240072T3 (es)
HK (1) HK1042686B (es)
HR (1) HRP20010577B1 (es)
HU (1) HUP0200650A3 (es)
IL (1) IL144697A0 (es)
IS (1) IS6036A (es)
MX (1) MXPA01007807A (es)
NO (1) NO20013818L (es)
PL (1) PL350317A1 (es)
PT (1) PT1154979E (es)
RU (1) RU2004127981A (es)
SK (1) SK10932001A3 (es)
TR (2) TR200103127T2 (es)
WO (1) WO2000046175A1 (es)
YU (1) YU55701A (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
CN1754872A (zh) 1999-11-30 2006-04-05 特瓦药厂有限公司 从发酵肉汤中回收抑素化合物的方法
CN1434702A (zh) 1999-12-14 2003-08-06 拜奥盖尔药厂有限公司 新的帕伐他丁钠形式
AU2002211462A1 (en) * 2000-10-05 2002-04-22 Teva Gyogyszergyar Reszvenytarsasag Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
CA2523233C (en) * 2003-04-25 2012-03-20 Nippon Chemiphar Co., Ltd. Salt of (2s,3s)-3-[[(1s)-1-isobutoxymethyl-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
DE04811862T1 (de) 2003-11-24 2006-03-02 Teva Gyogyszergyar Reszvenytarsasag Verfahren zur Reinigung von Pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
ATE540019T1 (de) * 2008-04-02 2012-01-15 Dsm Ip Assets Bv Extraktion von pravastatin
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1226923B (zh) * 1996-03-28 2011-06-15 Dsmip资产有限公司 粒状微生物生物量的制备及其有价值的化合物的分离方法

Also Published As

Publication number Publication date
JP2005047924A (ja) 2005-02-24
CA2361701C (en) 2007-04-10
RU2004127981A (ru) 2006-03-10
CN1347400A (zh) 2002-05-01
KR100648541B1 (ko) 2006-11-24
IS6036A (is) 2001-08-02
EP1154979A1 (en) 2001-11-21
CZ20012761A3 (cs) 2002-05-15
EP1154979B1 (en) 2005-05-04
BR0009180A (pt) 2002-03-26
YU55701A (sh) 2004-07-15
HUP0200650A2 (en) 2002-08-28
ATE294771T1 (de) 2005-05-15
AU2004214559A1 (en) 2004-10-21
TR200103127T2 (tr) 2002-04-22
JP4197312B2 (ja) 2008-12-17
AU774438B2 (en) 2004-06-24
ES2240072T3 (es) 2005-10-16
CN1260344C (zh) 2006-06-21
HK1042686B (zh) 2005-10-14
NO20013818D0 (no) 2001-08-03
KR20060061406A (ko) 2006-06-07
PT1154979E (pt) 2005-08-31
AR061765A2 (es) 2008-09-17
CN1177793C (zh) 2004-12-01
JP3645491B2 (ja) 2005-05-11
KR20010112257A (ko) 2001-12-20
TR200600009T2 (tr) 2006-08-21
CN1537935A (zh) 2004-10-20
JP2002535977A (ja) 2002-10-29
MXPA01007807A (es) 2003-06-04
SK10932001A3 (sk) 2002-06-04
DE60019898T2 (de) 2006-08-10
HRP20010577B1 (en) 2005-12-31
PL350317A1 (en) 2002-12-02
AU3356700A (en) 2000-08-25
AR023368A1 (es) 2002-09-04
CA2361701A1 (en) 2000-08-10
IL144697A0 (en) 2002-06-30
HK1042686A1 (en) 2002-08-23
NO20013818L (no) 2001-10-03
HRP20010577A2 (en) 2002-12-31
DE60019898D1 (de) 2005-06-09
EP1154979A4 (en) 2004-05-26
HUP0200650A3 (en) 2008-03-28
CN1590363A (zh) 2005-03-09
WO2000046175A1 (en) 2000-08-10

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