ATE271026T1 - Neue sälze von hmg-coa reductase inhibitoren - Google Patents
Neue sälze von hmg-coa reductase inhibitorenInfo
- Publication number
- ATE271026T1 ATE271026T1 AT99941798T AT99941798T ATE271026T1 AT E271026 T1 ATE271026 T1 AT E271026T1 AT 99941798 T AT99941798 T AT 99941798T AT 99941798 T AT99941798 T AT 99941798T AT E271026 T1 ATE271026 T1 AT E271026T1
- Authority
- AT
- Austria
- Prior art keywords
- hmg
- coa reductase
- reductase inhibitors
- amine salts
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
- C07C211/10—Diaminoethanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/07—Monoamines containing one, two or three alkyl groups, each having the same number of carbon atoms in excess of three
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9800240A SI20070A (sl) | 1998-09-18 | 1998-09-18 | Nove soli inhibitorjev HMG-CoA reduktaze |
PCT/IB1999/001554 WO2000017150A1 (en) | 1998-09-18 | 1999-09-17 | NEW SALTS OF HMG-CoA REDUCTASE INHIBITORS |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE271026T1 true ATE271026T1 (de) | 2004-07-15 |
Family
ID=20432331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99941798T ATE271026T1 (de) | 1998-09-18 | 1999-09-17 | Neue sälze von hmg-coa reductase inhibitoren |
Country Status (15)
Country | Link |
---|---|
US (4) | US6583295B1 (de) |
EP (2) | EP1466886A3 (de) |
JP (1) | JP3834203B2 (de) |
KR (1) | KR100699368B1 (de) |
CN (1) | CN1228304C (de) |
AT (1) | ATE271026T1 (de) |
AU (1) | AU765373C (de) |
CA (1) | CA2343646A1 (de) |
DE (1) | DE69918697T2 (de) |
HU (1) | HUP0103007A3 (de) |
IL (1) | IL142055A (de) |
IS (1) | IS2113B (de) |
NZ (1) | NZ509583A (de) |
SI (1) | SI20070A (de) |
WO (1) | WO2000017150A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0251582A (ja) * | 1988-08-12 | 1990-02-21 | Kyokado Eng Co Ltd | 地盤注入用薬液 |
AU782143B2 (en) * | 1998-09-18 | 2005-07-07 | Lek Pharmaceuticals D.D. | Crystals of the sodium salt of pravastatin |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
SI1154979T1 (en) * | 1999-02-03 | 2005-10-31 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
US6531507B1 (en) | 2000-06-09 | 2003-03-11 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
US6806290B2 (en) | 2000-06-09 | 2004-10-19 | Lek Pharmaceuticals D.D. | Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same |
CZ20031166A3 (cs) * | 2000-10-05 | 2004-04-14 | Biogal Gyogyszergyar Rt | Sodná sůl pravastatinu, která v podstatě neobsahuje pravastatin lakton a epi-pravastatin a kompozice na její bázi |
JP2002121172A (ja) * | 2000-10-16 | 2002-04-23 | Sankyo Co Ltd | プラバスタチン又はその薬理上許容される塩の精製方法 |
NL1017548C2 (nl) | 2001-03-09 | 2002-09-10 | Synthon Bv | Een lactonisatie proces. |
EP1404301A4 (de) * | 2001-06-21 | 2006-03-22 | Andrx Pharmaceuticals Inc | Pravastatin enthaltende stabile pharmazeutische zusammensetzungen mit kontrollierter freisetzung |
JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
JP2003093045A (ja) * | 2001-09-26 | 2003-04-02 | Godo Shusei Co Ltd | 有用変換微生物 |
DE60323835D1 (de) * | 2002-06-13 | 2008-11-13 | Novartis Ag | Calciumsalze von statinen aus indol |
US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
WO2005014541A1 (en) * | 2003-08-12 | 2005-02-17 | Biocon Limited | Novel antihypercholesterolemic compound |
EP1562912A2 (de) | 2003-08-28 | 2005-08-17 | Teva Pharmaceutical Industries Limited | Verfahren zur herstellung von rosuvastatin-calcium |
RU2315755C2 (ru) * | 2003-09-17 | 2008-01-27 | Уорнер-Ламберт Компани Ллс | Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1н-пиррол-1-гептановой кислоты |
GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
CA2546701C (en) * | 2003-11-24 | 2010-07-27 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
WO2005056534A1 (en) | 2003-12-02 | 2005-06-23 | Teva Pharmaceutical Industries Ltd. | Reference standard for characterization of rosuvastatin |
EP1709008A1 (de) * | 2004-01-19 | 2006-10-11 | Ranbaxy Laboratories Limited | Salze von hmg-coa-reduktase-inhibitoren und deren verwendung |
US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
JP2007536373A (ja) | 2004-05-05 | 2007-12-13 | ファイザー・プロダクツ・インク | アトルバスタチンの塩形態 |
US7179916B2 (en) | 2004-07-13 | 2007-02-20 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of rosuvastatin |
MX2007001558A (es) * | 2004-08-06 | 2008-03-13 | Transform Pharmaceuticals Inc | Formulaciones novedosas de fenofibrato y metodos de tratamiento relacionados. |
US20090042979A1 (en) * | 2004-08-06 | 2009-02-12 | Transform Pharmaceuticals Inc. | Novel Statin Pharmaceutical Compositions and Related Methods of Treatment |
EP1786414A4 (de) * | 2004-08-06 | 2008-04-09 | Transform Pharmaceuticals Inc | Neue pharmazeutische statin-zusammensetzungen und relevante behandlungsverfahren |
WO2006072963A1 (en) * | 2005-01-10 | 2006-07-13 | Concord Biotech Limited | Process for preparing simvastatin from lovastatin amine salts in three steps |
EP1851206B1 (de) | 2005-02-22 | 2012-08-15 | Teva Pharmaceutical Industries, Ltd. | Rosuvastatin und seine salze die frei von rosuvastatin-alkylether sind und ein verfahren zu ihrer herstellung |
CA2499047A1 (en) * | 2005-03-01 | 2006-09-01 | Apotex Pharmachem Inc. | Process for producing atorvastatin hemicalcium |
JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
US7868169B2 (en) | 2005-08-16 | 2011-01-11 | Teva Pharmaceutical Industries, Ltd. | Crystalline rosuvastatin intermediate |
PL211815B1 (pl) * | 2007-11-19 | 2012-06-29 | Inst Chemii Organicznej Polska Akademia Nauk | Enzym esteraza lowastatyny osadzony na nośniku nierozpuszczalnym w wodzie, sposób osadzania enzymu, zastosowanie enzymu esterazy lowastatyny osadzonego na nosniku nierozpuszczalnym w wodzie, przepływowy reaktor biokatalityczny ze złożem oraz sposób wytwarzania i/lub oczyszczania symwastatyny |
WO2009078033A2 (en) * | 2007-12-18 | 2009-06-25 | Themis Medicare Limited | Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth |
WO2011089559A1 (en) * | 2010-01-22 | 2011-07-28 | Orchid Chemicals And Pharmaceuticals Limited | A novel polymorphic form of atorvastatin salts |
WO2012063115A2 (en) | 2010-11-11 | 2012-05-18 | Jubilant Life Sciences Ltd. | Process for the preparation of rosuvastatin calcium via novel amine intermediate |
CN114031496A (zh) * | 2021-11-30 | 2022-02-11 | 广东蓝宝制药有限公司 | 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
ES493726A0 (es) | 1979-07-27 | 1981-06-16 | Sankyo Co | Un procedimiento para la preparacion de sales y esteres, de monacolina k utiles como agentes antitlipercolesteremicos. |
US4342767A (en) | 1980-01-23 | 1982-08-03 | Merck & Co., Inc. | Hypocholesteremic fermentation products |
DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
JPS57123140A (en) | 1981-01-23 | 1982-07-31 | Sankyo Co Ltd | Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component |
JPS57185275A (en) | 1981-05-07 | 1982-11-15 | Sankyo Co Ltd | Tetrahydro-dum-4 and tetrahydro-isodum-4 and their derivatives |
US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
US5089523A (en) * | 1990-05-11 | 1992-02-18 | E. R. Squibb & Sons, Inc. | Fluorinated derivatives of mevinic acids |
US5223415A (en) | 1990-10-15 | 1993-06-29 | Merck & Co., Inc. | Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid) |
HU9203780D0 (en) * | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
US5763653A (en) | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Key intermediates in the manufacture of simvastatin |
US5763646A (en) * | 1997-03-13 | 1998-06-09 | Ranbaxy Laboratories, Ltd. | Process for manufacturing simvastatin from lovastatin or mevinolinic acid |
SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
-
1998
- 1998-09-18 SI SI9800240A patent/SI20070A/sl not_active IP Right Cessation
-
1999
- 1999-09-17 WO PCT/IB1999/001554 patent/WO2000017150A1/en active IP Right Grant
- 1999-09-17 US US09/787,387 patent/US6583295B1/en not_active Expired - Lifetime
- 1999-09-17 DE DE69918697T patent/DE69918697T2/de not_active Expired - Lifetime
- 1999-09-17 NZ NZ509583A patent/NZ509583A/en not_active IP Right Cessation
- 1999-09-17 EP EP04011699A patent/EP1466886A3/de not_active Withdrawn
- 1999-09-17 KR KR1020017000758A patent/KR100699368B1/ko not_active IP Right Cessation
- 1999-09-17 EP EP99941798A patent/EP1114021B1/de not_active Expired - Lifetime
- 1999-09-17 JP JP2000574060A patent/JP3834203B2/ja not_active Expired - Lifetime
- 1999-09-17 AT AT99941798T patent/ATE271026T1/de active
- 1999-09-17 IL IL14205599A patent/IL142055A/en not_active IP Right Cessation
- 1999-09-17 CA CA002343646A patent/CA2343646A1/en not_active Abandoned
- 1999-09-17 AU AU55285/99A patent/AU765373C/en not_active Expired
- 1999-09-17 CN CNB998110736A patent/CN1228304C/zh not_active Expired - Lifetime
- 1999-09-17 HU HU0103007A patent/HUP0103007A3/hu unknown
-
2001
- 2001-03-15 IS IS5891A patent/IS2113B/is unknown
-
2002
- 2002-12-16 US US10/320,285 patent/US6838566B2/en not_active Expired - Lifetime
-
2004
- 2004-10-15 US US10/966,000 patent/US20050049422A1/en not_active Abandoned
-
2007
- 2007-09-18 US US11/901,634 patent/US20080188552A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP3834203B2 (ja) | 2006-10-18 |
US20030120086A1 (en) | 2003-06-26 |
DE69918697T2 (de) | 2005-07-28 |
AU765373B2 (en) | 2003-09-18 |
DE69918697D1 (de) | 2004-08-19 |
JP2002526467A (ja) | 2002-08-20 |
CN1228304C (zh) | 2005-11-23 |
US6583295B1 (en) | 2003-06-24 |
EP1114021B1 (de) | 2004-07-14 |
SI20070A (sl) | 2000-04-30 |
IL142055A (en) | 2004-06-20 |
IS2113B (is) | 2006-06-15 |
IS5891A (is) | 2001-03-15 |
US20050049422A1 (en) | 2005-03-03 |
EP1114021A1 (de) | 2001-07-11 |
HUP0103007A2 (hu) | 2002-05-29 |
AU5528599A (en) | 2000-04-10 |
US20080188552A1 (en) | 2008-08-07 |
CA2343646A1 (en) | 2000-03-30 |
EP1466886A2 (de) | 2004-10-13 |
US6838566B2 (en) | 2005-01-04 |
KR20010071959A (ko) | 2001-07-31 |
HUP0103007A3 (en) | 2003-10-28 |
EP1466886A3 (de) | 2009-02-25 |
KR100699368B1 (ko) | 2007-03-27 |
AU765373C (en) | 2005-05-26 |
NZ509583A (en) | 2003-10-31 |
IL142055A0 (en) | 2002-03-10 |
CN1318046A (zh) | 2001-10-17 |
WO2000017150A1 (en) | 2000-03-30 |
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Legal Events
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