DE60037687D1 - Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe - Google Patents
Verfahren zur Rückgewinnung von Statinverbindungen aus einer FermentationsbrüheInfo
- Publication number
- DE60037687D1 DE60037687D1 DE60037687T DE60037687T DE60037687D1 DE 60037687 D1 DE60037687 D1 DE 60037687D1 DE 60037687 T DE60037687 T DE 60037687T DE 60037687 T DE60037687 T DE 60037687T DE 60037687 D1 DE60037687 D1 DE 60037687D1
- Authority
- DE
- Germany
- Prior art keywords
- recovery
- fermentation broth
- statin compounds
- statin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000855 fermentation Methods 0.000 title 1
- 230000004151 fermentation Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 abstract 1
- OQARDMYXSOFTLN-PZAWKZKUSA-N pravastatin lactone Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 OQARDMYXSOFTLN-PZAWKZKUSA-N 0.000 abstract 1
- 229960001495 pravastatin sodium Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16805699P | 1999-11-30 | 1999-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60037687D1 true DE60037687D1 (de) | 2008-02-14 |
Family
ID=22609918
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60031447T Expired - Fee Related DE60031447T2 (de) | 1999-11-30 | 2000-11-28 | Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe |
DE60037687T Expired - Lifetime DE60037687D1 (de) | 1999-11-30 | 2000-11-28 | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe |
DE04010770T Pending DE04010770T1 (de) | 1999-11-30 | 2000-11-28 | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60031447T Expired - Fee Related DE60031447T2 (de) | 1999-11-30 | 2000-11-28 | Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE04010770T Pending DE04010770T1 (de) | 1999-11-30 | 2000-11-28 | Verfahren zur Rückgewinnung von Statinverbindungen aus einer Fermentationsbrühe |
Country Status (22)
Country | Link |
---|---|
US (3) | US6444452B1 (de) |
EP (1) | EP1265604B1 (de) |
JP (5) | JP3881240B2 (de) |
KR (1) | KR20030026920A (de) |
CN (2) | CN1754872A (de) |
AT (2) | ATE382344T1 (de) |
AU (1) | AU1804601A (de) |
CA (1) | CA2393057C (de) |
CY (1) | CY1105925T1 (de) |
DE (3) | DE60031447T2 (de) |
DK (1) | DK1265604T3 (de) |
ES (2) | ES2273737T3 (de) |
HR (1) | HRP20020454A2 (de) |
HU (1) | HUP0204012A3 (de) |
MX (1) | MXPA02005283A (de) |
PL (1) | PL364918A1 (de) |
PT (1) | PT1265604E (de) |
RU (1) | RU2002114072A (de) |
SK (1) | SK7342002A3 (de) |
WO (1) | WO2001039768A1 (de) |
YU (1) | YU39102A (de) |
ZA (1) | ZA200203912B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7141602B2 (en) * | 1998-09-18 | 2006-11-28 | Lek Pharmaceuticals D.D. | Process for obtaining HMG-CoA reductase inhibitors of high purity |
US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
US6444452B1 (en) * | 1999-11-30 | 2002-09-03 | Biogal Gyogyszergyar Rt. | Process for recovering statin compounds from a fermentation broth |
CZ20021998A3 (cs) * | 1999-12-14 | 2003-02-12 | Biogal Gyogyszergyar Rt. | Nové formy sodné soli pravastatinu |
KR20030059173A (ko) * | 2000-10-05 | 2003-07-07 | 비오갈 기오기스제르갸르 알티. | 프라바스타틴 락톤과 에피-프라바스타틴을 실질적으로함유하지 않는 프라바스타틴 나트륨, 및 이를 포함하는조성물 |
US20050215636A1 (en) * | 2000-10-05 | 2005-09-29 | Vilmos Keri | Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same |
JP2002121172A (ja) * | 2000-10-16 | 2002-04-23 | Sankyo Co Ltd | プラバスタチン又はその薬理上許容される塩の精製方法 |
DE10119718A1 (de) * | 2001-04-21 | 2002-10-31 | Boehringer Ingelheim Pharma | Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff |
JP2003026634A (ja) * | 2001-07-17 | 2003-01-29 | Mercian Corp | プラバスタチンナトリウム塩の製造方法 |
US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
KR100540761B1 (ko) * | 2002-08-09 | 2006-01-16 | 코바이오텍 (주) | 프라바스타틴 나트륨의 제조방법 |
EP1477471A1 (de) * | 2003-05-14 | 2004-11-17 | Chunghwa Chemical Synthesis & Biotech Co., Ltd. | Verfahren zur Reinigung von Pravastin-Natrium aus einer Fermentationsbrühe |
JP2007512366A (ja) * | 2003-11-24 | 2007-05-17 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | プラバスタチンの精製方法 |
WO2005054253A1 (en) * | 2003-12-05 | 2005-06-16 | Biocon Limited | Process for the purification of macrolides |
WO2006046130A2 (en) * | 2004-10-29 | 2006-05-04 | Ranbaxy Laboratories Limited | Process for the preparation of pravastatin |
MX2007009229A (es) * | 2005-02-09 | 2007-09-25 | Teva Gyogyszergyar Zartkoruen | Metodos para realizar pravastatina de sodio. |
JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
DE102006028817A1 (de) * | 2006-06-21 | 2007-12-27 | Evonik Degussa Gmbh | Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen |
WO2009078033A2 (en) * | 2007-12-18 | 2009-06-25 | Themis Medicare Limited | Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth |
EP2274267B1 (de) * | 2008-04-02 | 2012-01-04 | DSM IP Assets B.V. | Extraktion von pravastatin |
IN2009MU00380A (de) * | 2009-02-18 | 2010-04-02 | ||
CN102993145B (zh) * | 2011-09-19 | 2015-06-03 | 北大方正集团有限公司 | 一种提取纯化洛伐他汀的方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
MX7065E (es) * | 1980-06-06 | 1987-04-10 | Sankyo Co | Un procedimiento microbiologico para preparar derivados de ml-236b |
ATE69602T1 (de) * | 1985-09-13 | 1991-12-15 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
US4857547A (en) * | 1988-01-07 | 1989-08-15 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
US4857522A (en) * | 1988-03-21 | 1989-08-15 | E. R. Squibb & Sons, Inc. | Derivatives of pravastatin for inhibiting cholesterol biosynthesis |
US5180589A (en) * | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
US5099035A (en) * | 1989-02-27 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
US5140012A (en) * | 1990-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Method for preventing onset of restenosis after angioplasty employing pravastatin |
US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
US5157025A (en) * | 1991-04-01 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug |
NZ250609A (en) * | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
SI9300303A (en) | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
US5942423A (en) | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
US5616595A (en) | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
AU6726398A (en) * | 1997-02-20 | 1998-09-09 | Gist-Brocades B.V. | Nitrogen feed in statin fermentation |
AU9264598A (en) | 1997-08-22 | 1999-03-16 | Gist-Brocades B.V. | Statin production by fermentation |
SI9800046A (sl) * | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
PL350317A1 (en) * | 1999-02-03 | 2002-12-02 | Inst Drug Res Ltd | Microbial process for preparing pravastatin |
HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
US6444452B1 (en) * | 1999-11-30 | 2002-09-03 | Biogal Gyogyszergyar Rt. | Process for recovering statin compounds from a fermentation broth |
KR20030059173A (ko) * | 2000-10-05 | 2003-07-07 | 비오갈 기오기스제르갸르 알티. | 프라바스타틴 락톤과 에피-프라바스타틴을 실질적으로함유하지 않는 프라바스타틴 나트륨, 및 이를 포함하는조성물 |
-
2000
- 2000-11-28 US US09/723,711 patent/US6444452B1/en not_active Expired - Fee Related
- 2000-11-28 ES ES00980834T patent/ES2273737T3/es not_active Expired - Lifetime
- 2000-11-28 WO PCT/US2000/032391 patent/WO2001039768A1/en active IP Right Grant
- 2000-11-28 SK SK734-2002A patent/SK7342002A3/sk unknown
- 2000-11-28 CA CA002393057A patent/CA2393057C/en not_active Expired - Fee Related
- 2000-11-28 AU AU18046/01A patent/AU1804601A/en not_active Abandoned
- 2000-11-28 YU YU39102A patent/YU39102A/sh unknown
- 2000-11-28 CN CNA2005100739122A patent/CN1754872A/zh active Pending
- 2000-11-28 CN CN00818725A patent/CN1433305A/zh active Pending
- 2000-11-28 DK DK00980834T patent/DK1265604T3/da active
- 2000-11-28 KR KR1020027006920A patent/KR20030026920A/ko not_active IP Right Cessation
- 2000-11-28 AT AT04010770T patent/ATE382344T1/de not_active IP Right Cessation
- 2000-11-28 EP EP00980834A patent/EP1265604B1/de not_active Expired - Lifetime
- 2000-11-28 JP JP2001541501A patent/JP3881240B2/ja not_active Expired - Fee Related
- 2000-11-28 RU RU2002114072/13A patent/RU2002114072A/ru not_active Application Discontinuation
- 2000-11-28 ES ES04010770T patent/ES2239937T1/es active Pending
- 2000-11-28 DE DE60031447T patent/DE60031447T2/de not_active Expired - Fee Related
- 2000-11-28 HU HU0204012A patent/HUP0204012A3/hu unknown
- 2000-11-28 MX MXPA02005283A patent/MXPA02005283A/es unknown
- 2000-11-28 DE DE60037687T patent/DE60037687D1/de not_active Expired - Lifetime
- 2000-11-28 PL PL00364918A patent/PL364918A1/xx unknown
- 2000-11-28 AT AT00980834T patent/ATE342717T1/de not_active IP Right Cessation
- 2000-11-28 PT PT00980834T patent/PT1265604E/pt unknown
- 2000-11-28 DE DE04010770T patent/DE04010770T1/de active Pending
-
2002
- 2002-05-16 ZA ZA200203912A patent/ZA200203912B/en unknown
- 2002-05-23 HR HR20020454A patent/HRP20020454A2/xx not_active Application Discontinuation
- 2002-07-23 US US10/200,149 patent/US6689590B2/en not_active Expired - Fee Related
-
2003
- 2003-11-05 US US10/700,567 patent/US20040115781A1/en not_active Abandoned
-
2004
- 2004-07-13 JP JP2004206262A patent/JP2004350687A/ja active Pending
-
2005
- 2005-10-19 JP JP2005304900A patent/JP2006055174A/ja not_active Withdrawn
-
2006
- 2006-05-22 JP JP2006141646A patent/JP2006273861A/ja active Pending
-
2007
- 2007-01-15 CY CY20071100052T patent/CY1105925T1/el unknown
-
2008
- 2008-02-06 JP JP2008026632A patent/JP4343987B2/ja not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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8332 | No legal effect for de |