AU9264598A - Statin production by fermentation - Google Patents

Statin production by fermentation

Info

Publication number
AU9264598A
AU9264598A AU92645/98A AU9264598A AU9264598A AU 9264598 A AU9264598 A AU 9264598A AU 92645/98 A AU92645/98 A AU 92645/98A AU 9264598 A AU9264598 A AU 9264598A AU 9264598 A AU9264598 A AU 9264598A
Authority
AU
Australia
Prior art keywords
fermentation
statin
production
statin production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU92645/98A
Inventor
Rudolf Gijsbertus Marie Luiten
Hugo Streekstra
Adriaantje Ykema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Gist Brocades BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades BV filed Critical Gist Brocades BV
Publication of AU9264598A publication Critical patent/AU9264598A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
AU92645/98A 1997-08-22 1998-08-24 Statin production by fermentation Abandoned AU9264598A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97306462 1997-08-22
EP97306462 1997-08-22
PCT/EP1998/005362 WO1999010499A1 (en) 1997-08-22 1998-08-24 Statin production by fermentation

Publications (1)

Publication Number Publication Date
AU9264598A true AU9264598A (en) 1999-03-16

Family

ID=8229475

Family Applications (1)

Application Number Title Priority Date Filing Date
AU92645/98A Abandoned AU9264598A (en) 1997-08-22 1998-08-24 Statin production by fermentation

Country Status (3)

Country Link
EP (1) EP1015600A1 (en)
AU (1) AU9264598A (en)
WO (1) WO1999010499A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1240844C (en) * 1999-01-20 2006-02-08 协和发酵工业株式会社 Process for producing HMG-CoA reductase inhibitors
EP1148122B1 (en) 1999-01-29 2009-09-02 Kyowa Hakko Bio Co., Ltd. PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR
SK7342002A3 (en) 1999-11-30 2004-03-02 Biogal Gyogyszergyar Process for recovering statin compounds from a fermentation broth
HUP0204005A3 (en) 1999-12-14 2003-05-28 Teva Gyogyszergyar Zartkoeruee Novel forms of pravastatin sodium, process for their preparation and pharmaceutical compositions containing them
KR100725559B1 (en) * 2001-09-27 2007-06-08 바이오콘 리미티드 Process for producing pravastatin sodium salt using streptomyces flavidovirens dsm 14455
CA2546377A1 (en) 2003-11-24 2005-06-09 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying pravastatin
US20100048938A1 (en) * 2006-06-22 2010-02-25 Marco Alexander Van Den Berg Fermentation of pravastatin
EP1953233A1 (en) * 2007-02-02 2008-08-06 LEK Pharmaceuticals d.d. Fermentation process for preparing pravastatin
EP2949324A1 (en) 2014-05-27 2015-12-02 Consorci Institut Catala de Ciencies Cardiovasculars Prevention and/or treatment of ischemia/reperfusion injury
PL3600278T3 (en) 2017-03-31 2021-08-02 Fundació Institut De Recerca De L'hospital De La Santa Creu I Sant Pau Statin for prevention/reduction of ischemia-related damage
EP3381452A1 (en) 2017-03-31 2018-10-03 Instituto Catalán de Ciencias Cardiovasculares (ICCC), Hospital de la Santa Creu i Sant Pau, Avda. Statin for prevention/reduction of ischemia-related damage

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7065E (en) * 1980-06-06 1987-04-10 Sankyo Co A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
JPS60130548A (en) * 1983-12-20 1985-07-12 Akira Endo Monacolin k and ml-236b derivative
DE3682557D1 (en) * 1985-09-13 1992-01-02 Sankyo Co HYDROXY-ML-236B DERIVATIVES, THEIR PRODUCTION AND USE.
CA2012025C (en) * 1989-03-14 1999-09-07 Yukiko Tsukuda Dna for expression and secretion
JP3012664B2 (en) * 1990-03-13 2000-02-28 三共株式会社 Transformation of filamentous fungi with vectors
CA2045951A1 (en) * 1990-07-06 1992-01-07 Steven Kovacevic Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity
WO1993008287A1 (en) * 1991-10-15 1993-04-29 Merck & Co., Inc. Novel bioprocesses for preparing 7-aca and 7-adac
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura

Also Published As

Publication number Publication date
WO1999010499A1 (en) 1999-03-04
EP1015600A1 (en) 2000-07-05

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase