YU39102A - Postupak dobijanja statina iz fermentacione smeše - Google Patents

Postupak dobijanja statina iz fermentacione smeše

Info

Publication number
YU39102A
YU39102A YU39102A YUP39102A YU39102A YU 39102 A YU39102 A YU 39102A YU 39102 A YU39102 A YU 39102A YU P39102 A YUP39102 A YU P39102A YU 39102 A YU39102 A YU 39102A
Authority
YU
Yugoslavia
Prior art keywords
compound
recovering
fermentation broth
statin compounds
salt
Prior art date
Application number
YU39102A
Other languages
English (en)
Inventor
Vilmos Keri
Lajos Deak
Ilona Forgacs
Csaba Szabo
Edit Arvai 66 Csillag Street Nagyne
Original Assignee
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22609918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU39102(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogal Gyogyszergyar Rt filed Critical Biogal Gyogyszergyar Rt
Publication of YU39102A publication Critical patent/YU39102A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Opisan je novi postupak za dobijanje jedinjenja iz fermentacione smeše, koji uključuje faze nastajanja obogaćenog rastvora jedinjenja ekstrakcijom, dobijanje soli jedinjenja iz obogaćenog rastvora, prečišćavanje soli jedinjenja i prevođenje tako dobijene soli jedinjenja u odgovarajuću metalnu so jedinjenja.[A novel process for recovering a compound from a fermentation broth that includes the stages of forming an enriched solution of the compound by extraction, obtaining a salt of the compound from the enriched solution, purifying a salt of the compound and trans-salifying the salt of the compound to a metal salt of the compound is disclosed.
YU39102A 1999-11-30 2000-11-28 Postupak dobijanja statina iz fermentacione smeše YU39102A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16805699P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
YU39102A true YU39102A (sh) 2006-01-16

Family

ID=22609918

Family Applications (1)

Application Number Title Priority Date Filing Date
YU39102A YU39102A (sh) 1999-11-30 2000-11-28 Postupak dobijanja statina iz fermentacione smeše

Country Status (22)

Country Link
US (3) US6444452B1 (sh)
EP (1) EP1265604B1 (sh)
JP (5) JP3881240B2 (sh)
KR (1) KR20030026920A (sh)
CN (2) CN1754872A (sh)
AT (2) ATE382344T1 (sh)
AU (1) AU1804601A (sh)
CA (1) CA2393057C (sh)
CY (1) CY1105925T1 (sh)
DE (3) DE60037687D1 (sh)
DK (1) DK1265604T3 (sh)
ES (2) ES2273737T3 (sh)
HR (1) HRP20020454A2 (sh)
HU (1) HUP0204012A3 (sh)
MX (1) MXPA02005283A (sh)
PL (1) PL364918A1 (sh)
PT (1) PT1265604E (sh)
RU (1) RU2002114072A (sh)
SK (1) SK7342002A3 (sh)
WO (1) WO2001039768A1 (sh)
YU (1) YU39102A (sh)
ZA (1) ZA200203912B (sh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
AU779306B2 (en) * 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物
JP2002121172A (ja) * 2000-10-16 2002-04-23 Sankyo Co Ltd プラバスタチン又はその薬理上許容される塩の精製方法
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1477471A1 (en) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Process for purifying pravastin sodium from a fermentation broth
WO2005051372A2 (en) * 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
WO2005054253A1 (en) * 2003-12-05 2005-06-16 Biocon Limited Process for the purification of macrolides
WO2006046130A2 (en) * 2004-10-29 2006-05-04 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
CA2595635A1 (en) * 2005-02-09 2006-08-17 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Methods of making pravastatin sodium
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
WO2009121870A1 (en) * 2008-04-02 2009-10-08 Dsm Ip Assets B.V. Pravastatin extraction
IN2009MU00380A (sh) * 2009-02-18 2010-04-02
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
US6165757A (en) * 1997-02-20 2000-12-26 Dsm N.V. Nitrogen feed in statin fermentation
EP1015600A1 (en) * 1997-08-22 2000-07-05 Dsm N.V. Statin production by fermentation
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
MXPA01007807A (es) * 1999-02-03 2003-06-04 Inst Drug Res Ltd Proceso microbiano para preparar pravastatina.
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
JP3881240B2 (ja) * 1999-11-30 2007-02-14 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 醗酵ブロスからスタチン化合物を回収するための方法
CN1468098A (zh) * 2000-10-05 2004-01-14 �ݰ¸Ƕ�ҩ�����޹�˾ 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物

Also Published As

Publication number Publication date
HUP0204012A3 (en) 2003-12-29
ES2239937T1 (es) 2005-10-16
DE60031447T2 (de) 2007-08-30
US20020187531A1 (en) 2002-12-12
DE04010770T1 (de) 2005-10-20
PL364918A1 (en) 2004-12-27
US6689590B2 (en) 2004-02-10
ZA200203912B (en) 2003-08-21
RU2002114072A (ru) 2004-07-20
CA2393057A1 (en) 2001-06-07
DE60037687D1 (de) 2008-02-14
US6444452B1 (en) 2002-09-03
US20040115781A1 (en) 2004-06-17
DE60031447D1 (de) 2006-11-30
CN1433305A (zh) 2003-07-30
WO2001039768A1 (en) 2001-06-07
JP2008109948A (ja) 2008-05-15
AU1804601A (en) 2001-06-12
EP1265604A1 (en) 2002-12-18
CY1105925T1 (el) 2011-04-06
CN1754872A (zh) 2006-04-05
JP2003515334A (ja) 2003-05-07
ATE382344T1 (de) 2008-01-15
HUP0204012A2 (hu) 2003-03-28
JP3881240B2 (ja) 2007-02-14
KR20030026920A (ko) 2003-04-03
SK7342002A3 (en) 2004-03-02
EP1265604B1 (en) 2006-10-18
MXPA02005283A (es) 2003-10-06
PT1265604E (pt) 2006-12-29
JP2006055174A (ja) 2006-03-02
EP1265604A4 (en) 2004-06-16
JP4343987B2 (ja) 2009-10-14
ATE342717T1 (de) 2006-11-15
JP2004350687A (ja) 2004-12-16
DK1265604T3 (da) 2007-02-05
HRP20020454A2 (en) 2005-10-31
JP2006273861A (ja) 2006-10-12
ES2273737T3 (es) 2007-05-16
CA2393057C (en) 2008-01-29

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