HUP9904328A2 - 3-(Hidroxi-metil)-cefalosporin oldószeres extrakciója - Google Patents

3-(Hidroxi-metil)-cefalosporin oldószeres extrakciója

Info

Publication number
HUP9904328A2
HUP9904328A2 HU9904328A HUP9904328A HUP9904328A2 HU P9904328 A2 HUP9904328 A2 HU P9904328A2 HU 9904328 A HU9904328 A HU 9904328A HU P9904328 A HUP9904328 A HU P9904328A HU P9904328 A2 HUP9904328 A2 HU P9904328A2
Authority
HU
Hungary
Prior art keywords
aqueous solution
solvent extraction
hydroxymethylcephalosporins
desacetyl
aca
Prior art date
Application number
HU9904328A
Other languages
English (en)
Inventor
Vicki H. Audia
Gary M. F. Lim
John M. Roubie
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP9904328A2 publication Critical patent/HUP9904328A2/hu
Publication of HUP9904328A3 publication Critical patent/HUP9904328A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cefalőspőrin közbenső vegyületeket, dezacetil-7-glűtaril-ACA-t ésdezacetil-cefalőspőrin D-t állítanak elő kőncentrált vizes őldatfőrmájában a fenti közbenső vegyületeket alacsőnyabb kőncentrációbantartalmazó vizes őldatból őldószeres extrakcióval, amelyhezciklőhexanőnt használnak, majd vizbe történő visszaextrahálással. Aközbenső vegyület kőncentrált vizes őldata őlyan főrmában van, amelyismert eljárásők alkalmazásával a 7-ACA gazdaságős előállításárahasználható. ŕ
HU9904328A 1996-07-29 1997-07-18 Solvent extraction of 3-hydroxymethylcephalosporins HUP9904328A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2237296P 1996-07-29 1996-07-29
US3021496P 1996-11-05 1996-11-05
PCT/US1997/012630 WO1998004564A1 (en) 1996-07-29 1997-07-18 Solvent extraction of 3-hydroxymethylcephalosporins

Publications (2)

Publication Number Publication Date
HUP9904328A2 true HUP9904328A2 (hu) 2000-06-28
HUP9904328A3 HUP9904328A3 (en) 2001-07-30

Family

ID=26695856

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904328A HUP9904328A3 (en) 1996-07-29 1997-07-18 Solvent extraction of 3-hydroxymethylcephalosporins

Country Status (8)

Country Link
US (1) US5801241A (hu)
EP (1) EP0918778A4 (hu)
JP (1) JP2001500114A (hu)
KR (1) KR20000029709A (hu)
CN (1) CN1065865C (hu)
AU (2) AU3661597A (hu)
HU (1) HUP9904328A3 (hu)
WO (2) WO1998004565A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9909108A (pt) * 1998-03-27 2000-12-12 Dsm Nv Novo processo para a produção fermentativa da cefalosporina
IT1312567B1 (it) 1999-05-21 2002-04-22 Antibioticos Spa Processo per la sintesi di derivati beta-lattamici.
GB0016338D0 (en) * 2000-07-03 2000-08-23 Zeneca Ltd Chemical process
GB0016336D0 (en) * 2000-07-03 2000-08-23 Zeneca Ltd Chemical process
EP1583764A1 (en) * 2003-01-06 2005-10-12 Lupin Limited A process for the manufacture of cefpodoxime proxetil
CN103421025B (zh) * 2012-05-21 2016-05-11 上海医药工业研究院 制备7α-甲氧基头孢菌素C的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3573296A (en) * 1968-07-01 1971-03-30 Bristol Myers Co Process for the preparation of 7-aminocephalosporanic acid
BE791288A (fr) * 1971-11-15 1973-05-14 Lilly Co Eli Recuperation de la cephalosporine c
US3830809A (en) * 1972-08-25 1974-08-20 Bristol Myers Co Bis-dicyclohexylamine n-carbisobutoxycephalosporin c
US3980644A (en) * 1973-04-23 1976-09-14 Eli Lilly And Company Pentavalent phosphorus amides of cephalosporins and separation process using same
GB1489231A (en) * 1974-02-20 1977-10-19 Alfa Farmaceutici Spa Process for the recovery of cephalosporin c and derivatives thereof
US3986644A (en) * 1975-05-21 1976-10-19 Diamond International Corporation Dispensing pump
GB2060610B (en) * 1979-07-19 1983-12-07 Glaxo Group Ltd Desaacetyl cephalosporin c production
US4908444A (en) * 1986-01-23 1990-03-13 Takeda Chemical Industries, Ltd. Method of producing cephem compounds
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
US5221739A (en) * 1992-01-09 1993-06-22 Eli Lilly And Company Acetylation of 3-hydroxymethyl cephalosporins

Also Published As

Publication number Publication date
CN1226250A (zh) 1999-08-18
WO1998004565A1 (en) 1998-02-05
AU3671397A (en) 1998-02-20
EP0918778A4 (en) 2000-08-09
WO1998004564A1 (en) 1998-02-05
HUP9904328A3 (en) 2001-07-30
EP0918778A1 (en) 1999-06-02
KR20000029709A (ko) 2000-05-25
US5801241A (en) 1998-09-01
AU3661597A (en) 1998-02-20
JP2001500114A (ja) 2001-01-09
CN1065865C (zh) 2001-05-16

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