YU63602A - Postupak za prečišćavanje fermentacionog bujona - Google Patents

Postupak za prečišćavanje fermentacionog bujona

Info

Publication number
YU63602A
YU63602A YU63602A YUP63602A YU63602A YU 63602 A YU63602 A YU 63602A YU 63602 A YU63602 A YU 63602A YU P63602 A YUP63602 A YU P63602A YU 63602 A YU63602 A YU 63602A
Authority
YU
Yugoslavia
Prior art keywords
fermentation broth
crystallization
purifying
purified
pretreatment
Prior art date
Application number
YU63602A
Other languages
English (en)
Inventor
Vilmos Keri
Lajos Deak
Ilona Forgacs
Original Assignee
Biogal Gyogyszergyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar Rt. filed Critical Biogal Gyogyszergyar Rt.
Publication of YU63602A publication Critical patent/YU63602A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Otkriven je postupak za prečišćavanje statinskih jedinjenja iz fermentacionog bujona putem ekstrakcije i kristalizacije. Fermentacioni bujon je podvrgnut proceduri predtretmana koja uključuje alkalni predtretman i alkalno prečišćavanje. Nakon procedure predtretmana, kompaktinsko jedinjenje je ekstrahovano u kiselim uslovima u hidrofobni rastvarač i prečišćeno kristalizacijom. Organski ekstrakcioni rastvarač je koncentrisan i zatim ekstrahovan sa blagom bazom. Statinsko jedinjenje je zatim prečišćeno kristalizacijom.[A process for purifying statin compounds from a fermentation broth by extraction and crystallization is disclosed. A fermentation broth is subjected to a pretreatment procedure which involves an alkaline pretreatment and an alkaline purification. Following the pretreatment procedure, the statin compound is extracted under acidic conditions into a hydrophobic solvent and purified by crystallization. The organic extraction solvent is concentrated and then extracted with a mild base. The statin compound is then purified by crystallization.
YU63602A 2000-02-24 2001-01-25 Postupak za prečišćavanje fermentacionog bujona YU63602A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18452200P 2000-02-24 2000-02-24

Publications (1)

Publication Number Publication Date
YU63602A true YU63602A (sh) 2006-01-16

Family

ID=22677241

Family Applications (1)

Application Number Title Priority Date Filing Date
YU63602A YU63602A (sh) 2000-02-24 2001-01-25 Postupak za prečišćavanje fermentacionog bujona

Country Status (18)

Country Link
US (1) US6387258B1 (sh)
EP (1) EP1263979A4 (sh)
JP (1) JP3740062B2 (sh)
KR (1) KR20030013373A (sh)
CN (1) CN1406283A (sh)
AU (2) AU2001236543B2 (sh)
CA (1) CA2400952A1 (sh)
CZ (1) CZ20022779A3 (sh)
HR (1) HRP20020683A2 (sh)
HU (1) HUP0300073A3 (sh)
IL (1) IL151290A0 (sh)
IS (1) IS6521A (sh)
PL (1) PL357946A1 (sh)
RU (1) RU2265665C2 (sh)
SK (1) SK12012002A3 (sh)
WO (1) WO2001062949A1 (sh)
YU (1) YU63602A (sh)
ZA (1) ZA200206496B (sh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7452692B2 (en) * 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
ZA200406350B (en) * 2002-02-13 2006-11-29 Teva Gyogyszergyar Reszveny Tarsasag Method for extracting a macrolide from biomatter
ES2204285B1 (es) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. Procedimiento para el aislamiento y purificacion de lovastatina.
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
TW200504079A (en) * 2003-03-31 2005-02-01 Biogal Gyogyszergyar Crystallization and purification of macrolides
TW200513539A (en) * 2003-06-09 2005-04-16 Biogal Gyogyszergyar Ion-exchange filtration of fermentation broth
US7220357B2 (en) * 2003-07-24 2007-05-22 Teva Gyógyszergyár Zártkörúen Múkó´dó´Résvénytársaság Method of purifying macrolides
ES2239533B1 (es) * 2004-03-01 2006-12-16 Ercros Industrial, S.A. Procedimiento para la obtencion de compactina.
MXPA06011658A (es) * 2004-05-14 2006-12-14 Pfizer Prod Inc Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
EP1828204A1 (en) * 2004-12-22 2007-09-05 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Method of purifying macrolides
AU2008304180B2 (en) * 2007-09-27 2014-02-27 Genomatica, Inc. Reduction of the toxic effect of impurities from raw materials by extractive fermentation
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
US20120156794A1 (en) * 2008-03-19 2012-06-21 Florian Schweigert Method for the extraction and detection of fat-soluble components from biological materials
EP2103309A3 (de) * 2008-03-19 2012-09-12 SCHWEIGERT, Florian Verfahren zur Extraktion und zum Nachweis von fettlöslichen Inhaltsstoffen aus biologischen Materialien
IN2009MU00380A (sh) * 2009-02-18 2010-04-02
WO2010117342A1 (en) * 2009-04-08 2010-10-14 Nanyang Polytechnic A plant extract comprising statins and preparation techniques and uses thereof
CN102746262B (zh) * 2011-04-22 2014-06-04 广东蓝宝制药有限公司 一种康百汀纯化方法
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺
CN102827123B (zh) * 2012-08-02 2015-04-22 丽珠集团新北江制药股份有限公司 美伐他汀的分离提取工艺
US9861962B2 (en) * 2013-10-08 2018-01-09 Industry Foundation Of Chonnam National University Selective surface impregnation method for catalytically active materials on particulate catalyst support using mutual repulsive force and soblubility difference between hydrophilic solvent and hydrophobic solvent
RU2585234C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Способ получения компактина
RU2585233C2 (ru) * 2013-12-27 2016-05-27 Открытое акционерное общество "Красфарма" Промышленный способ получения компактина
CN106083789A (zh) * 2016-06-07 2016-11-09 山东鲁抗医药股份有限公司 从发酵液中沉淀分离提取洛伐他汀的方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

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US4049495A (en) 1974-06-07 1977-09-20 Sankyo Company Limited Physiologically active substances and fermentative process for producing the same
JPS5612114B2 (sh) 1974-06-07 1981-03-18
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
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HU208997B (en) 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300047A (en) 1993-01-29 1994-09-30 Krka Microbiological method for preparation of lovostatin and/or mevinoline acid
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SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy

Also Published As

Publication number Publication date
RU2265665C2 (ru) 2005-12-10
CZ20022779A3 (cs) 2003-02-12
IL151290A0 (en) 2003-04-10
CA2400952A1 (en) 2001-08-30
EP1263979A1 (en) 2002-12-11
JP3740062B2 (ja) 2006-01-25
HUP0300073A2 (en) 2003-05-28
US6387258B1 (en) 2002-05-14
AU3654301A (en) 2001-09-03
JP2003523751A (ja) 2003-08-12
KR20030013373A (ko) 2003-02-14
CN1406283A (zh) 2003-03-26
EP1263979A4 (en) 2003-05-21
RU2002122746A (ru) 2004-02-20
IS6521A (is) 2002-08-22
HRP20020683A2 (en) 2004-12-31
ZA200206496B (en) 2003-09-23
AU2001236543B2 (en) 2005-02-03
SK12012002A3 (sk) 2003-02-04
HUP0300073A3 (en) 2004-10-28
PL357946A1 (en) 2004-08-09
WO2001062949A1 (en) 2001-08-30

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