ATE296357T1 - Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitoren - Google Patents
Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitorenInfo
- Publication number
- ATE296357T1 ATE296357T1 AT99915976T AT99915976T ATE296357T1 AT E296357 T1 ATE296357 T1 AT E296357T1 AT 99915976 T AT99915976 T AT 99915976T AT 99915976 T AT99915976 T AT 99915976T AT E296357 T1 ATE296357 T1 AT E296357T1
- Authority
- AT
- Austria
- Prior art keywords
- coa reductase
- hmg
- reductase inhibitor
- crystallization
- reductase inhibitors
- Prior art date
Links
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title abstract 6
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title abstract 6
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002425 crystallisation Methods 0.000 abstract 4
- 230000008025 crystallization Effects 0.000 abstract 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000002028 Biomass Substances 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800046A SI9800046A (sl) | 1998-02-18 | 1998-02-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| PCT/IB1999/000808 WO1999042601A1 (en) | 1998-02-18 | 1999-02-17 | PROCESS FOR THE OBTAINING OF HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296357T1 true ATE296357T1 (de) | 2005-06-15 |
Family
ID=20432203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99915976T ATE296357T1 (de) | 1998-02-18 | 1999-02-17 | Verfahren zur herstellung von hochreinen hmg-coa reductase inhibitoren |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6825015B1 (de) |
| EP (1) | EP1054993B1 (de) |
| JP (2) | JP2002504345A (de) |
| KR (1) | KR100582620B1 (de) |
| CN (1) | CN1206363C (de) |
| AT (1) | ATE296357T1 (de) |
| AU (1) | AU743619B2 (de) |
| BG (1) | BG64289B1 (de) |
| CA (1) | CA2321052A1 (de) |
| CZ (1) | CZ297093B6 (de) |
| DE (1) | DE69925459T2 (de) |
| HR (1) | HRP20000541A2 (de) |
| HU (1) | HUP0100820A3 (de) |
| IL (1) | IL137782A0 (de) |
| PL (1) | PL193510B1 (de) |
| RO (1) | RO120922B1 (de) |
| RU (1) | RU2235130C2 (de) |
| SI (2) | SI9800046A (de) |
| SK (1) | SK285074B6 (de) |
| WO (1) | WO1999042601A1 (de) |
| YU (1) | YU50100A (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444452B1 (en) * | 1999-11-30 | 2002-09-03 | Biogal Gyogyszergyar Rt. | Process for recovering statin compounds from a fermentation broth |
| CZ20021998A3 (cs) | 1999-12-14 | 2003-02-12 | Biogal Gyogyszergyar Rt. | Nové formy sodné soli pravastatinu |
| RU2265665C2 (ru) * | 2000-02-24 | 2005-12-10 | Тева Джиоджисзерджиар Ресзвенитаршашаг | Способ очистки ферментационного бульона |
| TR200403001T3 (tr) | 2000-03-03 | 2005-02-21 | Plus Chemical, S.A. | Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem |
| IN192861B (de) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| US6936731B2 (en) * | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| RU2261901C2 (ru) * | 2003-10-17 | 2005-10-10 | Буяновский Эдуард Константинович | Штамм гриба aspergillus terreus № 44-62 - продуцент ловастатина, промышленный способ выделения ловастатина и способ лактонизации статинов |
| EP1641447B1 (de) | 2003-11-24 | 2008-10-29 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Verfahren zur reinigung von pravastatin |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
| CN102384955B (zh) * | 2010-09-01 | 2014-04-30 | 北京北大维信生物科技有限公司 | 人体血浆中HMG－CoA还原酶抑制剂的定量分析方法 |
| RU2585233C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Промышленный способ получения компактина |
| RU2585234C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Способ получения компактина |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4294846A (en) * | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
| PT85109A (en) | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
| US5202029A (en) | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| WO1997006128A1 (en) * | 1995-08-03 | 1997-02-20 | Gist-Brocades B.V. | Selective process for the deacylation of acylated compounds |
| EA000954B1 (ru) * | 1995-12-06 | 2000-08-28 | Балканфарма - Разград Ад | Способ получения ловастатина |
| HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
-
1998
- 1998-02-18 SI SI9800046A patent/SI9800046A/sl not_active IP Right Cessation
-
1999
- 1999-02-17 RU RU2000124064/13A patent/RU2235130C2/ru not_active IP Right Cessation
- 1999-02-17 HU HU0100820A patent/HUP0100820A3/hu unknown
- 1999-02-17 JP JP2000532541A patent/JP2002504345A/ja active Pending
- 1999-02-17 EP EP99915976A patent/EP1054993B1/de not_active Expired - Lifetime
- 1999-02-17 CA CA002321052A patent/CA2321052A1/en not_active Abandoned
- 1999-02-17 HR HR20000541A patent/HRP20000541A2/xx not_active Application Discontinuation
- 1999-02-17 WO PCT/IB1999/000808 patent/WO1999042601A1/en not_active Ceased
- 1999-02-17 IL IL13778299A patent/IL137782A0/xx not_active IP Right Cessation
- 1999-02-17 YU YU50100A patent/YU50100A/sh unknown
- 1999-02-17 US US09/600,566 patent/US6825015B1/en not_active Expired - Fee Related
- 1999-02-17 AT AT99915976T patent/ATE296357T1/de active
- 1999-02-17 SK SK1185-2000A patent/SK285074B6/sk not_active IP Right Cessation
- 1999-02-17 AU AU34384/99A patent/AU743619B2/en not_active Ceased
- 1999-02-17 RO ROA200000828A patent/RO120922B1/ro unknown
- 1999-02-17 PL PL99342513A patent/PL193510B1/pl unknown
- 1999-02-17 SI SI9930812T patent/SI1054993T1/xx unknown
- 1999-02-17 CZ CZ20002856A patent/CZ297093B6/cs not_active IP Right Cessation
- 1999-02-17 CN CNB998030805A patent/CN1206363C/zh not_active Expired - Fee Related
- 1999-02-17 DE DE69925459T patent/DE69925459T2/de not_active Expired - Lifetime
- 1999-02-17 KR KR1020007009056A patent/KR100582620B1/ko not_active Expired - Fee Related
-
2000
- 2000-08-17 BG BG104696A patent/BG64289B1/bg unknown
-
2004
- 2004-12-22 JP JP2004372018A patent/JP2005110693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20002856A3 (cs) | 2000-11-15 |
| WO1999042601A1 (en) | 1999-08-26 |
| CA2321052A1 (en) | 1999-08-26 |
| HUP0100820A3 (en) | 2003-07-28 |
| SK11852000A3 (sk) | 2001-05-10 |
| IL137782A0 (en) | 2001-10-31 |
| YU50100A (sh) | 2003-07-07 |
| JP2002504345A (ja) | 2002-02-12 |
| BG104696A (en) | 2001-07-31 |
| RU2235130C2 (ru) | 2004-08-27 |
| US6825015B1 (en) | 2004-11-30 |
| AU743619B2 (en) | 2002-01-31 |
| KR20010041024A (ko) | 2001-05-15 |
| DE69925459D1 (de) | 2005-06-30 |
| SI1054993T1 (en) | 2005-10-31 |
| RO120922B1 (ro) | 2006-09-29 |
| PL342513A1 (en) | 2001-06-18 |
| SK285074B6 (sk) | 2006-05-04 |
| JP2005110693A (ja) | 2005-04-28 |
| CZ297093B6 (cs) | 2006-09-13 |
| HUP0100820A2 (hu) | 2001-08-28 |
| CN1206363C (zh) | 2005-06-15 |
| DE69925459T2 (de) | 2006-04-27 |
| SI9800046A (sl) | 1999-08-31 |
| HRP20000541A2 (en) | 2001-12-31 |
| KR100582620B1 (ko) | 2006-05-23 |
| CN1291238A (zh) | 2001-04-11 |
| EP1054993A1 (de) | 2000-11-29 |
| PL193510B1 (pl) | 2007-02-28 |
| BG64289B1 (bg) | 2004-08-31 |
| AU3438499A (en) | 1999-09-06 |
| EP1054993B1 (de) | 2005-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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