YU50100A - Postupak za dobivanje inhibitora hmg-coa reduktaze visoke čistoće - Google Patents
Postupak za dobivanje inhibitora hmg-coa reduktaze visoke čistoćeInfo
- Publication number
- YU50100A YU50100A YU50100A YU50100A YU50100A YU 50100 A YU50100 A YU 50100A YU 50100 A YU50100 A YU 50100A YU 50100 A YU50100 A YU 50100A YU 50100 A YU50100 A YU 50100A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- hmg
- coa reductase
- reductase inhibitor
- crystallization
- water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
Opisan je postupak za izolovanje i prečišćavanje inhibitora HMG-CoA reduktaze iz biomase micelijuma, koji obuhvata razbistravanje čorbe micelijuma i koncentrovanje izbistrene čorbe do niže zapremine, zakišeljavanje koncentrata do pH vrednosti u oblasti od 4,5 do 7,5 što je praćeno sa ekstrakcijom inhibitora HMG-CoA reduktaze sa etil acetatom, vršenje kristalizacije inhibitora HMG-CoA reduktaze iz vodeno-mešljivog ili vodeno-solubilnog rastvarača, i vršenje kristalizacije inhibotora HMG-CoA reduktaze iz organskog rastvarača koji ima ograničenu mešljovost ili ograničenu solubilnost sa vodom. Poredak kristalizacionih stupnjeva može takodje da bude obrnut. Koncept kombinacije specifiziranih kristalizacionih stupnjeva može takodje da bude korišćen za prečišćavanje sirovog inhibitora HMG-CoA reduktaze.[A process for the isolation and purification of HMG-CoA reductase inhibitors from a mycelium biomass is described, which process comprises: clarifying a mycelium broth and concentrating the clarified broth to a lower volume, acidifying of the concentrate to a pH value in the range of 4.5 to 7.5, followed by extracting the HMG-CoA reductase inhibitor with ethyl acetate, crystallization of the HMG-CoA reductase inhibitor from a water-miscible or water-soluble organic solvent, and crystallization of the HMG-CoA reductase inhibitor from an organic solvent having limited miscibility or solubility with water. The crystallization steps may also be reverse. The concept of a combination of the specified crystallization steps can also be used for the purification of a crude HMG-CoA reductase inhibitor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800046A SI9800046A (sl) | 1998-02-18 | 1998-02-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU50100A true YU50100A (sh) | 2003-07-07 |
Family
ID=20432203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU50100A YU50100A (sh) | 1998-02-18 | 1999-02-17 | Postupak za dobivanje inhibitora hmg-coa reduktaze visoke čistoće |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6825015B1 (sh) |
| EP (1) | EP1054993B1 (sh) |
| JP (2) | JP2002504345A (sh) |
| KR (1) | KR100582620B1 (sh) |
| CN (1) | CN1206363C (sh) |
| AT (1) | ATE296357T1 (sh) |
| AU (1) | AU743619B2 (sh) |
| BG (1) | BG64289B1 (sh) |
| CA (1) | CA2321052A1 (sh) |
| CZ (1) | CZ297093B6 (sh) |
| DE (1) | DE69925459T2 (sh) |
| HR (1) | HRP20000541A2 (sh) |
| HU (1) | HUP0100820A3 (sh) |
| IL (1) | IL137782A0 (sh) |
| PL (1) | PL193510B1 (sh) |
| RO (1) | RO120922B1 (sh) |
| RU (1) | RU2235130C2 (sh) |
| SI (2) | SI9800046A (sh) |
| SK (1) | SK285074B6 (sh) |
| WO (1) | WO1999042601A1 (sh) |
| YU (1) | YU50100A (sh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1433305A (zh) * | 1999-11-30 | 2003-07-30 | 拜奥盖尔药厂有限公司 | 从发酵肉汤中回收抑素化合物的方法 |
| HUP0204005A3 (en) | 1999-12-14 | 2003-05-28 | Teva Gyogyszergyar Zartkoeruee | Novel forms of pravastatin sodium, process for their preparation and pharmaceutical compositions containing them |
| HUP0300073A3 (en) * | 2000-02-24 | 2004-10-28 | Teva Gyogyszergyar Zartkoeruee | Method of purifying a fermentation broth |
| IL151583A0 (en) | 2000-03-03 | 2003-04-10 | Plus Chemicals Bv | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
| IN192861B (sh) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| US6936731B2 (en) * | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| PL1641447T3 (pl) | 2003-11-24 | 2009-04-30 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Sposób oczyszczania prawastatyny |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
| CN102384955B (zh) * | 2010-09-01 | 2014-04-30 | 北京北大维信生物科技有限公司 | 人体血浆中HMG－CoA还原酶抑制剂的定量分析方法 |
| RU2585233C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Промышленный способ получения компактина |
| RU2585234C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Способ получения компактина |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4294846A (en) | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
| PT85109A (en) * | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
| US5202029A (en) | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| JPH11501218A (ja) * | 1995-08-03 | 1999-02-02 | ギスト ブロカデス ベスローテン フェンノートシャップ | アシル化された化合物の脱アシル化の選択的方法 |
| DE69614571T2 (de) | 1995-12-06 | 2002-06-27 | Balkanpharma-Razgard Ad, Razgard | Verfahren zur herstellung von lovastatin |
| HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
-
1998
- 1998-02-18 SI SI9800046A patent/SI9800046A/sl not_active IP Right Cessation
-
1999
- 1999-02-17 DE DE69925459T patent/DE69925459T2/de not_active Expired - Lifetime
- 1999-02-17 IL IL13778299A patent/IL137782A0/xx not_active IP Right Cessation
- 1999-02-17 SK SK1185-2000A patent/SK285074B6/sk not_active IP Right Cessation
- 1999-02-17 RO ROA200000828A patent/RO120922B1/ro unknown
- 1999-02-17 JP JP2000532541A patent/JP2002504345A/ja active Pending
- 1999-02-17 SI SI9930812T patent/SI1054993T1/xx unknown
- 1999-02-17 EP EP99915976A patent/EP1054993B1/en not_active Expired - Lifetime
- 1999-02-17 HU HU0100820A patent/HUP0100820A3/hu unknown
- 1999-02-17 CZ CZ20002856A patent/CZ297093B6/cs not_active IP Right Cessation
- 1999-02-17 YU YU50100A patent/YU50100A/sh unknown
- 1999-02-17 WO PCT/IB1999/000808 patent/WO1999042601A1/en active IP Right Grant
- 1999-02-17 CA CA002321052A patent/CA2321052A1/en not_active Abandoned
- 1999-02-17 RU RU2000124064/13A patent/RU2235130C2/ru not_active IP Right Cessation
- 1999-02-17 KR KR1020007009056A patent/KR100582620B1/ko not_active IP Right Cessation
- 1999-02-17 US US09/600,566 patent/US6825015B1/en not_active Expired - Fee Related
- 1999-02-17 PL PL99342513A patent/PL193510B1/pl unknown
- 1999-02-17 AU AU34384/99A patent/AU743619B2/en not_active Ceased
- 1999-02-17 CN CNB998030805A patent/CN1206363C/zh not_active Expired - Fee Related
- 1999-02-17 AT AT99915976T patent/ATE296357T1/de active
-
2000
- 2000-08-16 HR HR20000541A patent/HRP20000541A2/xx not_active Application Discontinuation
- 2000-08-17 BG BG104696A patent/BG64289B1/bg unknown
-
2004
- 2004-12-22 JP JP2004372018A patent/JP2005110693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20002856A3 (cs) | 2000-11-15 |
| EP1054993B1 (en) | 2005-05-25 |
| SI9800046A (sl) | 1999-08-31 |
| CZ297093B6 (cs) | 2006-09-13 |
| WO1999042601A1 (en) | 1999-08-26 |
| CN1206363C (zh) | 2005-06-15 |
| SI1054993T1 (en) | 2005-10-31 |
| KR20010041024A (ko) | 2001-05-15 |
| HRP20000541A2 (en) | 2001-12-31 |
| RU2235130C2 (ru) | 2004-08-27 |
| HUP0100820A2 (hu) | 2001-08-28 |
| SK11852000A3 (sk) | 2001-05-10 |
| ATE296357T1 (de) | 2005-06-15 |
| AU743619B2 (en) | 2002-01-31 |
| US6825015B1 (en) | 2004-11-30 |
| HUP0100820A3 (en) | 2003-07-28 |
| SK285074B6 (sk) | 2006-05-04 |
| EP1054993A1 (en) | 2000-11-29 |
| PL193510B1 (pl) | 2007-02-28 |
| AU3438499A (en) | 1999-09-06 |
| DE69925459D1 (de) | 2005-06-30 |
| CN1291238A (zh) | 2001-04-11 |
| JP2002504345A (ja) | 2002-02-12 |
| BG64289B1 (bg) | 2004-08-31 |
| PL342513A1 (en) | 2001-06-18 |
| JP2005110693A (ja) | 2005-04-28 |
| DE69925459T2 (de) | 2006-04-27 |
| BG104696A (en) | 2001-07-31 |
| KR100582620B1 (ko) | 2006-05-23 |
| IL137782A0 (en) | 2001-10-31 |
| RO120922B1 (ro) | 2006-09-29 |
| CA2321052A1 (en) | 1999-08-26 |
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