AR013876A1 - Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo - Google Patents

Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo

Info

Publication number
AR013876A1
AR013876A1 ARP970105539A ARP970105539A AR013876A1 AR 013876 A1 AR013876 A1 AR 013876A1 AR P970105539 A ARP970105539 A AR P970105539A AR P970105539 A ARP970105539 A AR P970105539A AR 013876 A1 AR013876 A1 AR 013876A1
Authority
AR
Argentina
Prior art keywords
clavulanic acid
pharmaceutically acceptable
production
acceptable salts
procedure
Prior art date
Application number
ARP970105539A
Other languages
English (en)
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of AR013876A1 publication Critical patent/AR013876A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D503/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para la produccion de ácido clavulánico y sales farmacéuticamente aceptables del mismo por: a) fermentacion de unmicroorganismo que es capaz de producir ácido clavulánico; b) aislacion de ácido clavulánico apartir del caldo de fermentacion; c) purificacionde ácido clavulánico, por ejemplo a través de una sal del mismo; d) conversion del ácido clavulánico purificado del paso c), por ejemplo de una sal del mismoen una sal farmacéuticamente aceptable delácido clavulánico, en donde el caldo de fermentacion es extraido con un solvente antes de la aislaciondel ácido clavulánico.
ARP970105539A 1996-11-27 1997-11-26 Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo AR013876A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0206296A AT404728B (de) 1996-11-27 1996-11-27 Verfahren zur herstellung von clavulansäure-aminsalzen

Publications (1)

Publication Number Publication Date
AR013876A1 true AR013876A1 (es) 2001-01-31

Family

ID=3526971

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105539A AR013876A1 (es) 1996-11-27 1997-11-26 Un procedimiento para la produccion de acido clavulanico y sales farmaceuticamente aceptables del mismo

Country Status (9)

Country Link
EP (1) EP0941229B1 (es)
JP (1) JP2001504508A (es)
KR (1) KR20000069057A (es)
AR (1) AR013876A1 (es)
AT (1) AT404728B (es)
AU (1) AU5556298A (es)
CA (1) CA2273021A1 (es)
DE (1) DE69724641T2 (es)
WO (1) WO1998023622A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001087891A1 (en) * 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
GB0022841D0 (en) 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
ATE286057T1 (de) * 2000-10-20 2005-01-15 Sandoz Ag Pharmazeutische zubereitungen enthaltend clavulansäure
WO2014128538A1 (en) * 2013-02-22 2014-08-28 Vardhman Chemtech Limited A process for the preparation of amoxicillin trihydrate
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109535183A (zh) * 2017-09-21 2019-03-29 联邦制药(内蒙古)有限公司 一种制备克拉维酸叔辛胺的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
EP0026044B1 (en) * 1979-08-24 1983-06-08 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
ES2010144A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un procedimiento de floculacion-coagulacion de caldos de fermentacion de streptomyces sp. que permite la obtencion directa de liquidos completamente transparentes.
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법

Also Published As

Publication number Publication date
DE69724641T2 (de) 2004-08-05
ATA206296A (de) 1998-06-15
KR20000069057A (ko) 2000-11-25
AT404728B (de) 1999-02-25
EP0941229A1 (en) 1999-09-15
AU5556298A (en) 1998-06-22
JP2001504508A (ja) 2001-04-03
CA2273021A1 (en) 1998-06-04
EP0941229B1 (en) 2003-09-03
WO1998023622A1 (en) 1998-06-04
DE69724641D1 (de) 2003-10-09

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Legal Events

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