ES2108572T3 - Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804. - Google Patents

Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804.

Info

Publication number
ES2108572T3
ES2108572T3 ES95909194T ES95909194T ES2108572T3 ES 2108572 T3 ES2108572 T3 ES 2108572T3 ES 95909194 T ES95909194 T ES 95909194T ES 95909194 T ES95909194 T ES 95909194T ES 2108572 T3 ES2108572 T3 ES 2108572T3
Authority
ES
Spain
Prior art keywords
organic phase
clavulanic acid
purified
isolation
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95909194T
Other languages
English (en)
Inventor
Egidij Capuder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20431337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2108572(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Application granted granted Critical
Publication of ES2108572T3 publication Critical patent/ES2108572T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Seasonings (AREA)

Abstract

SE HA DESCUBIERTO UN PROCESO NUEVO Y MEJORADO PARA EL AISLAMIENTO DE ACIDO CLAVULANICO Y SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO COMO CLAVULANATO POTASICO A PARTIR DEL CALDO DE CULTIVO DE FERMENTACION ACUOSA DE ESTREPTOMICES SP P 6621 FERM P 2804, EN DONDE A PARTIR DEL CALDO DE CULTIVO DE FERMENTACION ACUOSA EL MICELIUM, UNA MAYOR PARTE DE LAS PROTEINAS Y DE OTRAS PARTICULAS SOLIDAS SUSPENDIDAS SON ELIMINADAS POR MICROFILTRACION EN UN VALOR DE PH DEL MEDIO ENTRE 5.8 Y 6.2 Y A UNA TEMPERATURA ENTRE APROX. 20 ADO (LA FASE ACUOSA) ES OPCIONAL Y ADICIONALMENTE PURIFICADO POR ULTRAFILTRACION, Y EL CALDO DE CULTIVO PURIFICADO DE ESTA MANERA ES CONCENTRADO POR OSMOSIS INVERSA, DESPUES ES DIRECTAMENTE EXTRAIDO EN UNA CONTRACORRIENTE EN EXTRACTORES CENTRIFUGOS CON UN DISOLVENTE ORGANICO INMISCIBLE EN AGUA EN UN VALOR DE PH DEL MEDIO ENTRE 1 Y 3, CON LO CUAL LAS PROTEINAS TODAVIA RESTANTES SON ELIMINADAS SIMULTANEAMENTE, DE LA FASE ORGANICA OBTENIDA LAS IMPUREZAS SOLUBLES EN AGUA SON ELIMINADASLAVANDO LA FASE ORGANICA CON AGUA, LA FASE ORGANICA ES SECADA IN VACUO EN UNA COLUMNA DE RECTIFICACION PARA UN CONTENIDO EN AGUA INFERIOR A UN 0.1 % VOL. Y DESPUES CONCENTRADA POR EVAPORACION, DESCOLORADA POR UN TRATAMIENTO CON CARBONO ACTIVO, Y DESPUES EL ACIDO CLAVULANICO PRESENTE EN LA FASE ORGANICA SECA, MAS CORRECTAMENTE EN LA FASE DE ACETATO DE ETILO, ES AISLADO Y PURIFICADO POR UNA REACCION CON N,N''-DIISOPROPILETILENDIAMINA A UNA TEMPERATURA DE APROX. TEMPERATURA AMBIENTE PARA EL INTERMEDIARIO DICLAVULANATO DE N,N''DIISOPROPILETILENODIAMONICO QUE ES AISLADO Y DESPUES REACCIONANDO CON HEXANOATO 2-ETILO POTASICO EN ISOPROPANOL PARA PRODUCIR LA SAL POTASICA DEL ACIDO CLAVULANICO QUE TENGA ALTA PUREZA
ES95909194T 1994-03-02 1995-02-23 Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804. Expired - Lifetime ES2108572T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.

Publications (1)

Publication Number Publication Date
ES2108572T3 true ES2108572T3 (es) 1997-12-16

Family

ID=20431337

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95909194T Expired - Lifetime ES2108572T3 (es) 1994-03-02 1995-02-23 Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804.

Country Status (25)

Country Link
US (4) US5780274A (es)
EP (1) EP0748387B1 (es)
JP (1) JP2948661B2 (es)
KR (1) KR100293172B1 (es)
CN (1) CN1055694C (es)
AT (1) ATE159549T1 (es)
AU (1) AU694176B2 (es)
BG (1) BG62213B1 (es)
CA (1) CA2184619A1 (es)
CZ (1) CZ284117B6 (es)
DE (1) DE69500925T2 (es)
DK (1) DK0748387T3 (es)
ES (1) ES2108572T3 (es)
FI (1) FI963408A7 (es)
GR (1) GR3025942T3 (es)
HU (1) HUT74944A (es)
NO (1) NO318374B1 (es)
NZ (1) NZ279958A (es)
PL (1) PL180520B1 (es)
RO (1) RO118760B1 (es)
RU (1) RU2206613C2 (es)
SI (1) SI9400107A (es)
SK (1) SK279780B6 (es)
WO (1) WO1995023870A1 (es)
ZA (1) ZA951689B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
JP2001503763A (ja) * 1996-11-11 2001-03-21 ギスト ブロカデス ベスローテン フェンノートシャップ クラバラン酸の塩及びエステルの調製法
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DE69700903T2 (de) 1997-03-24 2000-07-06 Cipan-Companhia Industrial Produtora De Antibioticos, S.A. Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
WO2000041478A2 (en) * 1999-04-01 2000-07-20 Dsm N.V. Agglomerates by crystallisation
KR100827898B1 (ko) 2000-05-13 2008-05-07 스미스클라인비이참피이엘시이 클라불란산의 염의 정제 방법
GB0022841D0 (en) * 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
KR100443082B1 (ko) * 2002-10-18 2004-08-04 삼성전자주식회사 반도체 장치의 트랜지스터 제조 방법
CN100482338C (zh) * 2003-10-10 2009-04-29 帝斯曼知识产权资产管理有限公司 活性碳处理
KR100768476B1 (ko) 2005-11-24 2007-10-18 한국해양연구원 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물
CN102838624B (zh) * 2012-09-07 2014-10-29 安徽普朗膜技术有限公司 一种从发酵液中纯化克拉维酸的方法
CN104910194A (zh) * 2015-05-28 2015-09-16 高希章 一种克拉维酸钾的制备方法及其复方制剂

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873425A (en) * 1971-11-19 1975-03-25 Tatsuyoshi Kobayashi Process for producing itaconic acid
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4140764A (en) * 1974-12-18 1979-02-20 Beecham Group Limited β-Lactamase inhibitors and process for their preparation
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
US4148880A (en) * 1975-08-13 1979-04-10 Pfizer Inc. Mixture of antibiotics produced by a species of actinoplanes
GB1563103A (en) 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
JPS55162993A (en) * 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE2948607A1 (de) 1979-12-03 1981-06-11 Chemische Fabrik Dr. Meyer-Castens & Co Nfg., 2000 Hamburg Verfahren zur herstellung eines emulgators auf lecithinbasis
JPS5791196A (en) * 1980-11-27 1982-06-07 Takeda Chem Ind Ltd Separation of inosine, guanosine or their mixture from cell bodies and high polymeric substances
DE3146190A1 (de) 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
JPS6070092A (ja) * 1983-09-26 1985-04-20 Ajinomoto Co Inc グルタミン酸発酵液からのグルタミン酸結晶の取得法
US4911847A (en) 1983-12-20 1990-03-27 Membrex, Inc. Process for controlling the permeate composition in a rotary filtration device
AR245221A1 (es) 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
GB8521516D0 (en) 1985-08-29 1985-10-02 Beecham Group Plc Compounds
IT1221982B (it) * 1987-07-08 1990-08-31 Mini Ricerca Scient Tecnolog Antibiotici ab 006 e processo per la loro produzione
DE3730868A1 (de) * 1987-09-15 1989-03-23 Henkel Kgaa Verfahren zur abtrennung von biotechnisch hergestellten wertstoffen aus einer fermenterbruehe durch querstrom-mikro- und/oder ultrafiltration
GB8823706D0 (en) * 1988-10-10 1988-11-16 Alcan Int Ltd Microfilter device
ES2010144A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un procedimiento de floculacion-coagulacion de caldos de fermentacion de streptomyces sp. que permite la obtencion directa de liquidos completamente transparentes.
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5024937A (en) * 1989-04-06 1991-06-18 Dow Corning Corporation Method for processing aqueous fermentation broths
DE69013471T2 (de) * 1989-12-05 1995-03-30 Merck & Co Inc Methode zur Stabilisierung von rekombinanten Hepatitis-B-Virus-Oberflächenproteinen aus Hefe.
DE4005132A1 (de) 1990-02-17 1991-08-22 Akzo Gmbh Verfahren zum herstellen von hohlfadenstapeln
US5240600A (en) 1990-07-03 1993-08-31 International Environmental Systems, Inc., Usa Water and wastewater treatment system
JP3021562B2 (ja) * 1990-07-16 2000-03-15 ダイセル化学工業株式会社 ナイシンの製造方法
US5073263A (en) 1990-09-21 1991-12-17 Fagundes Carlos A Method and article for restraining extrusion of feed spacers and circumferential expansion in spiral filtration modules
US5268283A (en) * 1990-10-05 1993-12-07 Miles Inc. Method for the production of detergent builder formulations utilizing spray granulated citric acid and salts thereof
DE4031854A1 (de) * 1990-10-08 1992-04-09 Basf Ag Mikroorganismus und verfahren zur gewinnung von anthranilsaeure
JP2615272B2 (ja) * 1991-03-22 1997-05-28 日本碍子株式会社 蛋白質溶液中の蛋白有価物の回収方法
US5470356A (en) 1991-10-11 1995-11-28 Meszaros; Laszlo A. Sulfur dye compositions and their production
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB9222841D0 (en) 1992-10-31 1992-12-16 Smithkline Beecham Plc Novel process
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
JPH08509857A (ja) 1993-01-07 1996-10-22 シーケノム・インコーポレーテッド マススペクトロメトリーによるｄｎａ配列決定法
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5741903A (en) 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
NZ263564A (en) * 1993-03-26 1995-12-21 Gist Brocades Nv Tertiary, tertiary diamine mono and di salts of clavulanic acid; purification of clavulanic acid
US5760218A (en) 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
US5470481A (en) 1993-10-13 1995-11-28 Modell Environmental Corporation Method and apparatus for recovering wash water from pulp and paper mill effluent
WO1995011295A1 (en) 1993-10-22 1995-04-27 Gist-Brocades N.V. An improved process to recover an aqueous fermentation broth
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
AT400846B (de) 1994-02-25 1996-03-25 Fermic S A De C V Verfahren zur gewinnung und reinigung von alkalimetallsalzen der clavulansäure
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
JPH0873227A (ja) 1994-06-30 1996-03-19 Olympus Optical Co Ltd ガラス体の製造方法及びゲルの浸漬装置
US5650101A (en) 1994-07-25 1997-07-22 University Of South Florida Lock and key micelles
JP3617091B2 (ja) 1994-11-30 2005-02-02 味の素株式会社 塩基性アミノ酸の精製方法
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
AU691727B2 (en) 1995-02-25 1998-05-21 Spurcourt Limited Clavulanic acid salts
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ES2101658B1 (es) 1995-11-23 1998-03-01 Antibioticos Sa Nuevo procedimiento de produccion de acido clavulanico y sus sales.
US5837365A (en) 1996-04-08 1998-11-17 The Penn State Research Foundation Hydrophilic polypropylene membranes

Also Published As

Publication number Publication date
JP2948661B2 (ja) 1999-09-13
RO118760B1 (ro) 2003-10-30
PL316085A1 (en) 1996-12-23
BG100816A (en) 1997-10-31
US6207428B1 (en) 2001-03-27
US5780274A (en) 1998-07-14
FI963408A7 (fi) 1996-10-30
ATE159549T1 (de) 1997-11-15
WO1995023870A1 (en) 1995-09-08
FI963408A0 (fi) 1996-09-02
CN1143388A (zh) 1997-02-19
NO318374B1 (no) 2005-03-14
NZ279958A (en) 1997-04-24
BG62213B1 (bg) 1999-05-31
CZ255796A3 (en) 1996-12-11
EP0748387A1 (en) 1996-12-18
SI9400107A (en) 1995-10-31
HU9602351D0 (en) 1996-10-28
DE69500925D1 (de) 1997-11-27
EP0748387B1 (en) 1997-10-22
KR970701786A (ko) 1997-04-12
CN1055694C (zh) 2000-08-23
RU2206613C2 (ru) 2003-06-20
NO963628L (no) 1996-10-17
AU694176B2 (en) 1998-07-16
JPH09504702A (ja) 1997-05-13
US6566106B2 (en) 2003-05-20
NO963628D0 (no) 1996-08-30
AU1724195A (en) 1995-09-18
DE69500925T2 (de) 1998-02-12
CZ284117B6 (cs) 1998-08-12
CA2184619A1 (en) 1995-09-08
ZA951689B (en) 1995-12-11
US5985625A (en) 1999-11-16
KR100293172B1 (ko) 2001-06-15
DK0748387T3 (da) 1998-05-25
HUT74944A (en) 1997-03-28
PL180520B1 (pl) 2001-02-28
US20010007761A1 (en) 2001-07-12
SK112096A3 (en) 1997-02-05
GR3025942T3 (en) 1998-04-30
SK279780B6 (sk) 1999-03-12

Similar Documents

Publication Publication Date Title
ES2108572T3 (es) Procedimiento para el aislamiento de acido clavulanico y de sales farmaceuticamente aceptables de este a partir del caldo de fermentacion de streptomyces sp p 6621 ferm p 2804.
BE569728A (es)
JP5184465B2 (ja) クラブラン酸カリウムの製造方法
US6369219B2 (en) Preparation of clavulanate salts
US5994534A (en) Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
CN102153566A (zh) 头孢地尼的制备方法
JPS62181281A (ja) 大環式抗生物質及びその製造方法
CN113402572A (zh) 一种精制微生物发酵法制备的氨基葡萄糖复合盐的工艺
CN108586491B (zh) 一种盐酸头孢他美酯的制备方法
US4719287A (en) Higher alkyl pyrrolidone extractants for water soluble phenolic or carboxylic antibiotics
US2695261A (en) Production of polymyxins a, b, and e
US2916483A (en) Methymycin
EP1756055A1 (en) Process for the purification of tryptophan
EP0834574B1 (en) METHOD OF PURIFYING K-252a
JPS589676B2 (ja) ノジリマイシン ｂ ノ セイゾウホウ
AU692091C (en) Preparation of clavulanate salts
EP1452519A1 (en) Method for the isolation and purification of pravastatin sodium
JP2689643B2 (ja) ポリエン系抗生物質パートリシンｂの製造方法
BRPI0619157A2 (pt) processo para a preparação de um sal de potássio de penicilina
JPH0123473B2 (es)
CN101321771B (zh) 青霉素钾盐的制备工艺
JPS62293A (ja) Ｌ−ラムノ−スの製造法
SE203061C1 (es)
MXPA97009802A (es) Un proceso para la purificacion de (+) - k-252a
JPS6210639B2 (es)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 748387

Country of ref document: ES