ATE159549T1 - Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804 - Google Patents

Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804

Info

Publication number
ATE159549T1
ATE159549T1 AT95909194T AT95909194T ATE159549T1 AT E159549 T1 ATE159549 T1 AT E159549T1 AT 95909194 T AT95909194 T AT 95909194T AT 95909194 T AT95909194 T AT 95909194T AT E159549 T1 ATE159549 T1 AT E159549T1
Authority
AT
Austria
Prior art keywords
clavulanic acid
isolation
pharmaceutically acceptable
acceptable salts
fermentation broth
Prior art date
Application number
AT95909194T
Other languages
English (en)
Inventor
Egidij Capuder
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20431337&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE159549(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Application granted granted Critical
Publication of ATE159549T1 publication Critical patent/ATE159549T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Seasonings (AREA)
AT95909194T 1994-03-02 1995-02-23 Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804 ATE159549T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9400107A SI9400107A (en) 1994-03-02 1994-03-02 New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.

Publications (1)

Publication Number Publication Date
ATE159549T1 true ATE159549T1 (de) 1997-11-15

Family

ID=20431337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95909194T ATE159549T1 (de) 1994-03-02 1995-02-23 Verfahren zur isolation von clavulansäure und von pharmazeutisch verträgliche salze aus fermentationsbrühe von streptomyces sp.p6621 ferm p2804

Country Status (25)

Country Link
US (4) US5780274A (de)
EP (1) EP0748387B1 (de)
JP (1) JP2948661B2 (de)
KR (1) KR100293172B1 (de)
CN (1) CN1055694C (de)
AT (1) ATE159549T1 (de)
AU (1) AU694176B2 (de)
BG (1) BG62213B1 (de)
CA (1) CA2184619A1 (de)
CZ (1) CZ284117B6 (de)
DE (1) DE69500925T2 (de)
DK (1) DK0748387T3 (de)
ES (1) ES2108572T3 (de)
FI (1) FI963408A (de)
GR (1) GR3025942T3 (de)
HU (1) HUT74944A (de)
NO (1) NO318374B1 (de)
NZ (1) NZ279958A (de)
PL (1) PL180520B1 (de)
RO (1) RO118760B1 (de)
RU (1) RU2206613C2 (de)
SI (1) SI9400107A (de)
SK (1) SK279780B6 (de)
WO (1) WO1995023870A1 (de)
ZA (1) ZA951689B (de)

Families Citing this family (21)

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AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
EP0867515B1 (de) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure
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CA2364342C (en) * 1999-04-01 2011-02-01 Dsm N.V. Agglomerates by crystallisation
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
GB0022841D0 (en) * 2000-09-18 2000-11-01 Smithkline Beecham Plc Process
KR100443082B1 (ko) * 2002-10-18 2004-08-04 삼성전자주식회사 반도체 장치의 트랜지스터 제조 방법
KR100768476B1 (ko) 2005-11-24 2007-10-18 한국해양연구원 항암물질을 생산하는 방선균 스트렙토마이세스 속 균주,이의 분리방법, 이로부터 반고형 추출물을 제조하는 방법,이로부터 유래한 반고형 추출물 및 이를 이용한 항암제조성물
CN102838624B (zh) * 2012-09-07 2014-10-29 安徽普朗膜技术有限公司 一种从发酵液中纯化克拉维酸的方法
CN104910194A (zh) * 2015-05-28 2015-09-16 高希章 一种克拉维酸钾的制备方法及其复方制剂

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Also Published As

Publication number Publication date
NO318374B1 (no) 2005-03-14
HU9602351D0 (en) 1996-10-28
CA2184619A1 (en) 1995-09-08
AU694176B2 (en) 1998-07-16
HUT74944A (en) 1997-03-28
WO1995023870A1 (en) 1995-09-08
ZA951689B (en) 1995-12-11
US6207428B1 (en) 2001-03-27
PL180520B1 (pl) 2001-02-28
US20010007761A1 (en) 2001-07-12
RO118760B1 (ro) 2003-10-30
RU2206613C2 (ru) 2003-06-20
DK0748387T3 (da) 1998-05-25
SK279780B6 (sk) 1999-03-12
US5985625A (en) 1999-11-16
KR970701786A (ko) 1997-04-12
ES2108572T3 (es) 1997-12-16
DE69500925T2 (de) 1998-02-12
GR3025942T3 (en) 1998-04-30
CZ255796A3 (en) 1996-12-11
EP0748387A1 (de) 1996-12-18
US6566106B2 (en) 2003-05-20
SK112096A3 (en) 1997-02-05
CZ284117B6 (cs) 1998-08-12
JPH09504702A (ja) 1997-05-13
PL316085A1 (en) 1996-12-23
NO963628L (no) 1996-10-17
AU1724195A (en) 1995-09-18
EP0748387B1 (de) 1997-10-22
BG62213B1 (bg) 1999-05-31
FI963408A (fi) 1996-10-30
CN1055694C (zh) 2000-08-23
CN1143388A (zh) 1997-02-19
SI9400107A (en) 1995-10-31
KR100293172B1 (ko) 2001-06-15
DE69500925D1 (de) 1997-11-27
NO963628D0 (no) 1996-08-30
NZ279958A (en) 1997-04-24
FI963408A0 (fi) 1996-09-02
JP2948661B2 (ja) 1999-09-13
BG100816A (en) 1997-10-31
US5780274A (en) 1998-07-14

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