ATE147103T1 - Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp. - Google Patents
Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp.Info
- Publication number
- ATE147103T1 ATE147103T1 AT90500023T AT90500023T ATE147103T1 AT E147103 T1 ATE147103 T1 AT E147103T1 AT 90500023 T AT90500023 T AT 90500023T AT 90500023 T AT90500023 T AT 90500023T AT E147103 T1 ATE147103 T1 AT E147103T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutically acceptable
- acceptable salts
- clavulic
- streptomyces
- obtaining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8900748A ES2010143A6 (es) | 1989-03-01 | 1989-03-01 | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE147103T1 true ATE147103T1 (de) | 1997-01-15 |
Family
ID=8260712
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90500023T ATE147103T1 (de) | 1989-03-01 | 1990-02-28 | Verfahren zur gewinnung von klavulinsäure und deren pharmazeutisch annehmbare salze aus fermentationskulturen von streptomyces sp. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0387178B9 (de) |
AT (1) | ATE147103T1 (de) |
DE (1) | DE69029527T3 (de) |
DK (1) | DK0387178T4 (de) |
ES (1) | ES2010143A6 (de) |
GR (1) | GR3022981T3 (de) |
PT (1) | PT93313B (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2010143A6 (es) † | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
AT400033B (de) * | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
AT399155B (de) * | 1992-03-26 | 1995-03-27 | Lek Tovarna Farmacevtskih | Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung |
AT1447U1 (de) * | 1992-06-11 | 1997-05-26 | Smithkline Beecham Plc | Neue salze von clavulansäure |
SI9300296B (sl) * | 1992-06-11 | 1998-06-30 | Smithkline Beecham P.L.C. | Postopek in intermedianti za pripravo klavulanske kisline |
GB2282810B (en) * | 1992-06-11 | 1997-02-26 | Smithkline Beecham Plc | Preparation or purification of clavulanic acid |
AT475U1 (de) * | 1992-06-11 | 1995-11-27 | Smithkline Beecham Plc | Verfahren zur herstellung von clavulansaeure |
AT1446U1 (de) * | 1992-10-31 | 1997-05-26 | Smithkline Beecham Plc | Verfahren zur herstellung und/oder reinigung von clavulansäure |
GB9305565D0 (en) * | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds and processes |
HUT69372A (en) * | 1993-03-26 | 1995-09-28 | Gist Brocades Nv | Diamine salts of clarulanic acid, pharmaceutical compositions containing the same and process for their production |
US5741903A (en) * | 1993-03-26 | 1998-04-21 | Gist-Brocades N.V. | Diamine salts for purification of clavulanic acid |
US5760218A (en) * | 1993-03-26 | 1998-06-02 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
US5821364A (en) * | 1993-03-26 | 1998-10-13 | Gist-Brocades N.V. | Diamine salts of clavulanic acid |
DE4318916A1 (de) * | 1993-06-07 | 1994-12-08 | Bayer Ag | Cyclobutylazole |
SI9400107A (en) * | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9426261D0 (en) | 1994-12-24 | 1995-02-22 | Spurcourt Ltd | Clavulanic acid salts |
DE69618045D1 (de) * | 1995-02-25 | 2002-01-31 | Spurcourt Ltd | Clavulansäure Salz |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
AT404728B (de) * | 1996-11-27 | 1999-02-25 | Biochemie Gmbh | Verfahren zur herstellung von clavulansäure-aminsalzen |
CN1312814A (zh) * | 1998-07-16 | 2001-09-12 | Dsm公司 | 制备棒酸盐类及其酯类的改进方法 |
CN105384758B (zh) * | 2015-12-01 | 2018-05-01 | 国药集团威奇达药业有限公司 | 克拉维酸胺盐的制备方法 |
CN108546269B (zh) * | 2018-05-22 | 2019-10-11 | 国药集团威奇达药业有限公司 | 从结晶母液中回收克拉维酸叔丁胺盐的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4140764A (en) * | 1974-12-18 | 1979-02-20 | Beecham Group Limited | β-Lactamase inhibitors and process for their preparation |
GB1543563A (en) † | 1975-02-07 | 1979-04-04 | Glaxo Lab Ltd | Beta-lactam antibiotic in purified form |
DE3063683D1 (en) † | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
NZ213963A (en) * | 1984-10-27 | 1989-01-06 | Antibioticos Sa | Production of clavulanic acid |
ES2010143A6 (es) † | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
-
1989
- 1989-03-01 ES ES8900748A patent/ES2010143A6/es not_active Expired
-
1990
- 1990-02-28 DE DE69029527T patent/DE69029527T3/de not_active Expired - Lifetime
- 1990-02-28 DK DK90500023T patent/DK0387178T4/da active
- 1990-02-28 EP EP90500023A patent/EP0387178B9/de not_active Expired - Lifetime
- 1990-02-28 AT AT90500023T patent/ATE147103T1/de not_active IP Right Cessation
- 1990-03-01 PT PT93313A patent/PT93313B/pt not_active IP Right Cessation
-
1997
- 1997-03-31 GR GR970400657T patent/GR3022981T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69029527T3 (de) | 2001-11-08 |
EP0387178B2 (de) | 2001-04-18 |
EP0387178B1 (de) | 1997-01-02 |
EP0387178B9 (de) | 2002-09-25 |
DE69029527T2 (de) | 1997-07-24 |
DK0387178T4 (da) | 2001-07-30 |
DE69029527D1 (de) | 1997-02-13 |
ES2010143A6 (es) | 1989-10-16 |
GR3022981T3 (en) | 1997-06-30 |
PT93313B (pt) | 1998-06-30 |
DK0387178T3 (da) | 1997-06-16 |
EP0387178A1 (de) | 1990-09-12 |
PT93313A (pt) | 1990-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |