DE69119216D1 - Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate - Google Patents

Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate

Info

Publication number
DE69119216D1
DE69119216D1 DE69119216T DE69119216T DE69119216D1 DE 69119216 D1 DE69119216 D1 DE 69119216D1 DE 69119216 T DE69119216 T DE 69119216T DE 69119216 T DE69119216 T DE 69119216T DE 69119216 D1 DE69119216 D1 DE 69119216D1
Authority
DE
Germany
Prior art keywords
derivatives
production
enzymatic process
aminocephalosporic acid
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69119216T
Other languages
English (en)
Other versions
DE69119216T2 (de
Inventor
Stefano Cambiaghi
Sergio Tomaselli
Roberto Verga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olon SpA
Original Assignee
Antibioticos SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SpA filed Critical Antibioticos SpA
Application granted granted Critical
Publication of DE69119216D1 publication Critical patent/DE69119216D1/de
Publication of DE69119216T2 publication Critical patent/DE69119216T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
DE69119216T 1990-12-21 1991-12-18 Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate Expired - Fee Related DE69119216T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02251490A IT1252308B (it) 1990-12-21 1990-12-21 Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Publications (2)

Publication Number Publication Date
DE69119216D1 true DE69119216D1 (de) 1996-06-05
DE69119216T2 DE69119216T2 (de) 1996-09-05

Family

ID=11197293

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69119216T Expired - Fee Related DE69119216T2 (de) 1990-12-21 1991-12-18 Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate

Country Status (10)

Country Link
US (1) US5424196A (de)
EP (1) EP0496993B1 (de)
JP (1) JP2851021B2 (de)
KR (1) KR0180934B1 (de)
AT (1) ATE137535T1 (de)
CA (1) CA2058216C (de)
DE (1) DE69119216T2 (de)
ES (1) ES2086470T3 (de)
IE (1) IE75201B1 (de)
IT (1) IT1252308B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
TW198064B (de) * 1990-12-24 1993-01-11 Hoechst Ag
IT1250698B (it) * 1991-07-24 1995-04-21 Mini Ricerca Scient Tecnolog Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici.
GB2275925B (en) * 1993-03-08 1996-08-14 Asahi Chemical Ind A process for converting cephalosporin C to glutaryl-7-aminocephalosporanic acid
DE4342770A1 (de) * 1993-12-15 1995-07-06 Boehringer Mannheim Gmbh Trägerfixierte Enzyme
KR100345994B1 (ko) * 1994-06-22 2002-12-16 제일제당주식회사 7-아미노세팔로스포란산의효소적제조방법
EP0720611A1 (de) * 1994-07-22 1996-07-10 Antibioticos S.P.A. Glutaryl-7-aca-derivate und verfahren zu ihrem erhalt
KR100345847B1 (ko) * 1994-08-13 2002-12-16 제일제당주식회사 고정화효소에의한세파졸린의제조방법
CN1065278C (zh) * 1994-08-27 2001-05-02 中国科学院上海植物生理研究所 一步两酶法制造7－氨基头孢烷酸
ES2093555B1 (es) * 1995-02-24 1997-07-01 Antibioticos Sa Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.
IT1275909B1 (it) * 1995-03-07 1997-10-24 Mirella Pilone Frammento di dna codificante d-amminoacido ossidasi
KR0174117B1 (ko) * 1995-12-28 1999-02-01 윤원영 새로운 세팔로스포린 유도체 및 그 제조방법
ES2109194B1 (es) * 1996-04-22 1998-07-16 Antibioticos Sa Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.
WO1998004565A1 (en) * 1996-07-29 1998-02-05 Bristol-Myers Squibb Company Solvent extraction of 3-hydroxymethylcephalosporins
US5877013A (en) * 1997-07-31 1999-03-02 Food Industry Research And Development Institute Rhodosporidium D-amino acid oxidase
GB9718740D0 (en) 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
AU9742398A (en) 1997-09-09 1999-03-29 Biochemie Gesellschaft Mbh Esterase free enzymes
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
IT1312567B1 (it) * 1999-05-21 2002-04-22 Antibioticos Spa Processo per la sintesi di derivati beta-lattamici.
US20030050464A1 (en) * 2000-07-28 2003-03-13 Yi Hu Novel human proteases and polynucleotides encoding the same
CA2423161A1 (en) * 2000-09-22 2002-03-28 Bristol-Myers Squibb Company Glutaryl cephalosporin amidase from pseudomonas diminuta bs-203
AU2002310863A1 (en) 2001-04-19 2002-11-05 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives
US7985574B2 (en) * 2004-02-17 2011-07-26 American Air Liquide, Inc. Oxygen-assisted fermentation process
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
CN102505035B (zh) * 2011-10-25 2014-07-09 石药集团中诺药业（石家庄）有限公司 一种3-去乙酰基-7-氨基头孢烷酸的制备工艺
CN104364376B (zh) 2012-01-10 2017-06-13 幽兰化学医药有限公司 突变的头孢菌素羟化酶及其在脱乙酰基头孢菌烷酸合成中的应用
CN105543332A (zh) * 2016-01-06 2016-05-04 南阳师范学院 一种基于dab显色的cpc乙酰化酶高通量筛选的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
CA1041447A (en) * 1974-01-23 1978-10-31 Tadashiro Fujii Production of 7-amino-cephem compounds by comamonas and pseudomonas
JPS5417032B2 (de) * 1974-01-23 1979-06-27
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
GB1576103A (en) * 1976-02-19 1980-10-01 Glaxo Lab Ltd Transcarbamoylase enzyme and its use in producing 3-carbamoyloxymethyl cephalosporin antibiotics
JPS5467091A (en) * 1977-11-05 1979-05-30 Sumitomo Chem Co Ltd Carrier for immobilized enzyme and its preparation
JPS5548392A (en) * 1978-02-17 1980-04-07 Toyo Jozo Co Ltd Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support
JPS54154592A (en) * 1978-05-23 1979-12-05 Yamanouchi Pharmaceut Co Ltd Production of enzyme-fixed mold cells
SE8005266L (sv) * 1979-07-19 1981-01-20 Glaxo Group Ltd Framstellning av en cefalosporin genom jesning
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
DE3447023A1 (de) * 1984-12-22 1986-06-26 Hoechst Ag, 6230 Frankfurt Neue d-aminosaeure-transaminase und ihre verwendung
JPH0829114B2 (ja) * 1986-09-18 1996-03-27 旭化成工業株式会社 ７−アミノセフアロスポラン酸およびその誘導体の製造法
EP0275901B1 (de) * 1987-01-17 1993-06-09 Hoechst Aktiengesellschaft Verwendung von Gamma-Glutamyl-Transpeptidase
EP0322032A3 (de) * 1987-12-21 1991-01-30 Merck & Co. Inc. Enzymatische Umwandlung von Cephalosporin C und Derivaten in 7-Aminocephalosporinsäure und Derivate in einem Schritt
DE69019967T2 (de) * 1989-04-04 1996-02-22 Biopure Corp Enzymatisches verfahren zur herstellung von 7-aminocephalosporansäure.
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme

Also Published As

Publication number Publication date
EP0496993A1 (de) 1992-08-05
JP2851021B2 (ja) 1999-01-27
ES2086470T3 (es) 1996-07-01
KR0180934B1 (ko) 1999-04-01
EP0496993B1 (de) 1996-05-01
DE69119216T2 (de) 1996-09-05
US5424196A (en) 1995-06-13
JPH05211890A (ja) 1993-08-24
IE914462A1 (en) 1992-07-01
KR920012454A (ko) 1992-07-27
CA2058216C (en) 1999-12-14
IT9022514A0 (it) 1990-12-21
IE75201B1 (en) 1997-08-27
CA2058216A1 (en) 1992-06-22
ATE137535T1 (de) 1996-05-15
IT9022514A1 (it) 1992-06-21
IT1252308B (it) 1995-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee