ES2093555B1 - Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c. - Google Patents

Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.

Info

Publication number
ES2093555B1
ES2093555B1 ES09500369A ES9500369A ES2093555B1 ES 2093555 B1 ES2093555 B1 ES 2093555B1 ES 09500369 A ES09500369 A ES 09500369A ES 9500369 A ES9500369 A ES 9500369A ES 2093555 B1 ES2093555 B1 ES 2093555B1
Authority
ES
Spain
Prior art keywords
derivatives
amino
procedure
acilasas
aca
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES09500369A
Other languages
English (en)
Other versions
ES2093555A1 (es
Inventor
Seijas Jose Manuel Guisan
Rodriguez Veronica Rodriguez
Lafuente Roberto Fernandez
Codina M Agatha Bastida
Rodrguez M Del Carmen Ceinos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antibioticos SA
Original Assignee
Antibioticos SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos SA filed Critical Antibioticos SA
Priority to ES09500369A priority Critical patent/ES2093555B1/es
Publication of ES2093555A1 publication Critical patent/ES2093555A1/es
Application granted granted Critical
Publication of ES2093555B1 publication Critical patent/ES2093555B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Abstract

PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE D-AMINO ACIDO OXIDASAS Y GLUTARIL ACILASAS ALTAMENTE ESTABILIZADOS PARA SU USO COMO CATALIZADORES PARA LA PRODUCCION DE ACIDO 7-AMINO CEFALOSPORANICO (7-ACA) A PARTIR DE CEFALOSPORINA C. ESTE PROCEDIMIENTO ESTA BASADO EN EL DESARROLLO DE NUEVAS ESTRATEGIAS DE INMOVILIZACION DE ENZIMAS. DE ESTE MODO LOGRAMOS CONTROLAR LA ORIENTACION CON LA QUE LA ENZIMA SE INMOVILIZA SOBRE EL SOPORTE, LOGRAMOS CONTROLAR EL GRADO DE INMOVILIZACION MULTIPUNTUAL Y LOGRAMOS DESARROLLAR MODIFICACIONES QUIMICAS ADICIONALES DE LAS MOLECULAS DE ENZIMA YA INMOVILIZADAS. LOS DERIVADOS ENZIMATICOS ASI CONSEGUIDOS ERAN MUCHO MAS ESTABLES QUE LAS CORRESPONDIENTES ENZIMAS NATIVAS FRENTE A LOS EFECTOS INACTIVANTES DEL CALOR, PH DEL MEDIO Y DE LA PRESENCIA DE CONCENTRACIONES MODERADAS DE PEROXIDO DE HIDROGENO. DE ESTE MODO ESTA ESTABILIDAD MEJORADA DE ESTAS ENZIMAS NOS PERMITE UTILIZAR ESTOS DERIVADOS ENZIMATICOS PARA OPTIMIZAR EL DESARROLLO DE UN PROCESO DE ENORME INTERES EN LAINDUSTRIA FARMACEUTICA: LA OBTENCION DE 7-ACA, INTERMEDIO CLAVE PARA LA OBTENCION DE CEFALOSPORINAS SEMISINTETICAS.
ES09500369A 1995-02-24 1995-02-24 Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c. Expired - Fee Related ES2093555B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES09500369A ES2093555B1 (es) 1995-02-24 1995-02-24 Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09500369A ES2093555B1 (es) 1995-02-24 1995-02-24 Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.

Publications (2)

Publication Number Publication Date
ES2093555A1 ES2093555A1 (es) 1996-12-16
ES2093555B1 true ES2093555B1 (es) 1997-07-01

Family

ID=8289576

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09500369A Expired - Fee Related ES2093555B1 (es) 1995-02-24 1995-02-24 Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.

Country Status (1)

Country Link
ES (1) ES2093555B1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924632B4 (de) * 1999-05-28 2006-04-13 Sanofi-Aventis Deutschland Gmbh Verfahren zur Verzögerung der Desaktivierung von Glutarylamidase während einer Enzymkatalyse

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Also Published As

Publication number Publication date
ES2093555A1 (es) 1996-12-16

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