IT1252308B - Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati - Google Patents

Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Info

Publication number
IT1252308B
IT1252308B IT02251490A IT2251490A IT1252308B IT 1252308 B IT1252308 B IT 1252308B IT 02251490 A IT02251490 A IT 02251490A IT 2251490 A IT2251490 A IT 2251490A IT 1252308 B IT1252308 B IT 1252308B
Authority
IT
Italy
Prior art keywords
derivatives
production
aminocephalosporanic acid
enzymatic procedure
enzymatic
Prior art date
Application number
IT02251490A
Other languages
English (en)
Other versions
IT9022514A0 (it
IT9022514A1 (it
Inventor
Stefano Cambiaghi
Sergio Tomaselli
Roberto Verga
Original Assignee
Antibioticos Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antibioticos Spa filed Critical Antibioticos Spa
Publication of IT9022514A0 publication Critical patent/IT9022514A0/it
Priority to IT02251490A priority Critical patent/IT1252308B/it
Priority to ES91121677T priority patent/ES2086470T3/es
Priority to AT91121677T priority patent/ATE137535T1/de
Priority to EP91121677A priority patent/EP0496993B1/en
Priority to DE69119216T priority patent/DE69119216T2/de
Priority to IE446291A priority patent/IE75201B1/en
Priority to CA002058216A priority patent/CA2058216C/en
Priority to JP3354448A priority patent/JP2851021B2/ja
Priority to KR1019910023834A priority patent/KR0180934B1/ko
Publication of IT9022514A1 publication Critical patent/IT9022514A1/it
Priority to US08/176,520 priority patent/US5424196A/en
Application granted granted Critical
Publication of IT1252308B publication Critical patent/IT1252308B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
IT02251490A 1990-12-21 1990-12-21 Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati IT1252308B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT02251490A IT1252308B (it) 1990-12-21 1990-12-21 Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
DE69119216T DE69119216T2 (de) 1990-12-21 1991-12-18 Enzymatisches Verfahren zur Herstellung von 7-Aminocephalosporinsäure und Derivate
AT91121677T ATE137535T1 (de) 1990-12-21 1991-12-18 Enzymatisches verfahren zur herstellung von 7- aminocephalosporinsäure und derivate
EP91121677A EP0496993B1 (en) 1990-12-21 1991-12-18 Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
ES91121677T ES2086470T3 (es) 1990-12-21 1991-12-18 Procedimiento enzimatico para preparar acido 7-aminocefalosporanicos y sus derivados.
IE446291A IE75201B1 (en) 1990-12-21 1991-12-19 Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
CA002058216A CA2058216C (en) 1990-12-21 1991-12-20 Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives
JP3354448A JP2851021B2 (ja) 1990-12-21 1991-12-20 ７−アミノセファロスポラン酸及び誘導体の酵素調製法
KR1019910023834A KR0180934B1 (ko) 1990-12-21 1991-12-21 7-아미노세팔로스포란 산 및 이의 유도체를 제조하는 효소적 방법
US08/176,520 US5424196A (en) 1990-12-21 1994-01-03 Enzymatic process for preparing 7-aminocephalosporanic acid and derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02251490A IT1252308B (it) 1990-12-21 1990-12-21 Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Publications (3)

Publication Number Publication Date
IT9022514A0 IT9022514A0 (it) 1990-12-21
IT9022514A1 IT9022514A1 (it) 1992-06-21
IT1252308B true IT1252308B (it) 1995-06-08

Family

ID=11197293

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02251490A IT1252308B (it) 1990-12-21 1990-12-21 Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati

Country Status (10)

Country Link
US (1) US5424196A (it)
EP (1) EP0496993B1 (it)
JP (1) JP2851021B2 (it)
KR (1) KR0180934B1 (it)
AT (1) ATE137535T1 (it)
CA (1) CA2058216C (it)
DE (1) DE69119216T2 (it)
ES (1) ES2086470T3 (it)
IE (1) IE75201B1 (it)
IT (1) IT1252308B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
TW198064B (it) * 1990-12-24 1993-01-11 Hoechst Ag
IT1250698B (it) * 1991-07-24 1995-04-21 Mini Ricerca Scient Tecnolog Processo per la preparazione enzimatica di acidi 7-ammino-cefalosporanici.
ES2097080B1 (es) * 1993-03-08 1997-11-16 Asahi Chemical Ind Procedimiento para la conversion de cefalosporina c en acido glutaril-7-aminocefalosporanico.
DE4342770A1 (de) * 1993-12-15 1995-07-06 Boehringer Mannheim Gmbh Trägerfixierte Enzyme
KR100345994B1 (ko) * 1994-06-22 2002-12-16 제일제당주식회사 7-아미노세팔로스포란산의효소적제조방법
KR960704897A (ko) * 1994-07-22 1996-10-09 에밀리오 마우리 글루타릴 7-아미노세팔로스포란산 유도체 및 이의 제조 방법 (Glutaryl 7-ACA derivatives and processes for obtaining them)
KR100345847B1 (ko) * 1994-08-13 2002-12-16 제일제당주식회사 고정화효소에의한세파졸린의제조방법
CN1065278C (zh) * 1994-08-27 2001-05-02 中国科学院上海植物生理研究所 一步两酶法制造7－氨基头孢烷酸
ES2093555B1 (es) * 1995-02-24 1997-07-01 Antibioticos Sa Procedimiento de preparacion de derivados de d-amino acido oxidasas y glutaril acilasas altamente estabilizados para su uso como catalizadores para la produccion de acido 7-amino cefalosporanico (7-aca) a partir de cefalosporina c.
IT1275909B1 (it) * 1995-03-07 1997-10-24 Mirella Pilone Frammento di dna codificante d-amminoacido ossidasi
KR0174117B1 (ko) * 1995-12-28 1999-02-01 윤원영 새로운 세팔로스포린 유도체 및 그 제조방법
ES2109194B1 (es) * 1996-04-22 1998-07-16 Antibioticos Sa Un procedimiento para producir la enzima d-aminoacido oxidasa de rhodotorula gracilis en celulas hospedantes.
WO1998004565A1 (en) * 1996-07-29 1998-02-05 Bristol-Myers Squibb Company Solvent extraction of 3-hydroxymethylcephalosporins
US5877013A (en) * 1997-07-31 1999-03-02 Food Industry Research And Development Institute Rhodosporidium D-amino acid oxidase
GB9718740D0 (en) 1997-09-05 1997-11-12 Advanced Phytonics Ltd Improvements in or relating to the preparation of a compound
CN1174096C (zh) 1997-09-09 2004-11-03 生物化学有限公司 来自具有酶活性的微生物的球形颗粒,其制备方法及应用
FR2780416B1 (fr) * 1998-06-10 2002-12-20 Rhone Poulenc Nutrition Animal Procede industriel de production de proteines heterologues chez e. coli et souches utiles pour le procede
IT1312567B1 (it) * 1999-05-21 2002-04-22 Antibioticos Spa Processo per la sintesi di derivati beta-lattamici.
US20030050464A1 (en) * 2000-07-28 2003-03-13 Yi Hu Novel human proteases and polynucleotides encoding the same
ES2252302T3 (es) 2000-09-22 2006-05-16 Bristol-Myers Squibb Company Amidasa de glutaril cefalosporina a partir de pseudomonas diminuta bs-203.
EP1379531A2 (en) * 2001-04-19 2004-01-14 Bioferma Murcia, S.A. Enzymatic process for preparing cephalosporanic acid derivatives using alpha-ketoacid derivatives
US7985574B2 (en) * 2004-02-17 2011-07-26 American Air Liquide, Inc. Oxygen-assisted fermentation process
JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
CN102505035B (zh) * 2011-10-25 2014-07-09 石药集团中诺药业（石家庄）有限公司 一种3-去乙酰基-7-氨基头孢烷酸的制备工艺
WO2013105030A1 (en) 2012-01-10 2013-07-18 Orchid Chemicals And Pharmaceuticals Limited Mutated cephalosporin hydroxylase and its application in deacetylcephalosporanic acid synthesis
CN105543332A (zh) * 2016-01-06 2016-05-04 南阳师范学院 一种基于dab显色的cpc乙酰化酶高通量筛选的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1272769A (en) * 1968-08-02 1972-05-03 Glaxo Lab Ltd Improvements in or relating to cephalosporin derivatives
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
DK158316C (da) * 1974-01-23 1990-10-08 Toyo Jozo Kk Fremgangsmaade til fremstilling af 3-substituerede 7-amino-3-cephem-4-carboxylsyrederivater
JPS5417032B2 (it) * 1974-01-23 1979-06-27
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
GB1576103A (en) * 1976-02-19 1980-10-01 Glaxo Lab Ltd Transcarbamoylase enzyme and its use in producing 3-carbamoyloxymethyl cephalosporin antibiotics
JPS5467091A (en) * 1977-11-05 1979-05-30 Sumitomo Chem Co Ltd Carrier for immobilized enzyme and its preparation
JPS5548392A (en) * 1978-02-17 1980-04-07 Toyo Jozo Co Ltd Novel immobilizing material combined with biologically active substance, its preparation, device comprising it, method, and preparation of support
JPS54154592A (en) * 1978-05-23 1979-12-05 Yamanouchi Pharmaceut Co Ltd Production of enzyme-fixed mold cells
DK310880A (da) * 1979-07-19 1981-01-20 Glaxo Group Ltd Fremgangsmaade til fremstilling af en cephalosporinforbindelse ved gaering
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C
US4693977A (en) * 1982-08-23 1987-09-15 Queen's University At Kingston Enzyme immobilization for producing cephalosporin antibiotics
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
DE3447023A1 (de) * 1984-12-22 1986-06-26 Hoechst Ag, 6230 Frankfurt Neue d-aminosaeure-transaminase und ihre verwendung
JPH0829114B2 (ja) * 1986-09-18 1996-03-27 旭化成工業株式会社 ７−アミノセフアロスポラン酸およびその誘導体の製造法
EP0275901B1 (de) * 1987-01-17 1993-06-09 Hoechst Aktiengesellschaft Verwendung von Gamma-Glutamyl-Transpeptidase
EP0322032A3 (en) * 1987-12-21 1991-01-30 Merck & Co. Inc. One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives
ATE123533T1 (de) * 1989-04-04 1995-06-15 Biopure Corp Enzymatisches verfahren zur herstellung von 7- aminocephalosporansäure.
US5104800A (en) * 1989-06-27 1992-04-14 Merck & Co., Inc. One-step cephalosporin c amidase enzyme

Also Published As

Publication number Publication date
DE69119216T2 (de) 1996-09-05
CA2058216C (en) 1999-12-14
IE914462A1 (en) 1992-07-01
IT9022514A0 (it) 1990-12-21
JPH05211890A (ja) 1993-08-24
IE75201B1 (en) 1997-08-27
DE69119216D1 (de) 1996-06-05
EP0496993A1 (en) 1992-08-05
CA2058216A1 (en) 1992-06-22
IT9022514A1 (it) 1992-06-21
KR920012454A (ko) 1992-07-27
ATE137535T1 (de) 1996-05-15
ES2086470T3 (es) 1996-07-01
EP0496993B1 (en) 1996-05-01
KR0180934B1 (ko) 1999-04-01
JP2851021B2 (ja) 1999-01-27
US5424196A (en) 1995-06-13

Similar Documents

Publication Publication Date Title
IT1252308B (it) Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
ATE86665T1 (de) Verfahren zur herstellung der 2-keto-lgulons|ure.
SE9600797L (sv) Nya salter
DK0625571T3 (da) Mikroorganismer, deres anvendelse samt fremgangsmåde til fremstilling af L-alfa-aminosyrer
DK0409521T3 (da) Forbedret enzymatisk oxidation af Ceph C til glutaryl-7-aminocephalosporansyre
KR890016184A (ko) 베타-락탐(lactams)의 효소학적 제조방법
IT1240833B (it) Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
ES2177529T3 (es) Proceso enzimatico para la produccion de cefonicida.
ATE85814T1 (de) Verbessertes verfahren zur enzymatischen herstellung von l-2-amino-4-methylphosphinobutters|ure.
BR9301627A (pt) Processo para preparar cefalosporinas
PT89282A (pt) Processo para a hidrolise enzimatica de monoaminocompostos de alfa-aminoadipinilo
ES2042549T3 (es) Procedimiento enzimatico para obtencion de cefalosporinas 3-sustituidas.
ES2092730T3 (es) Procedimiento microbiologico para la preparacion de acido 5-hidroxi-2-pirazina-carboxilico.
IT1252307B (it) Procedimento enzimatico per la produzione di acido 7b- (4carbossibutanamido) cefalosporanici.
BG50560A1 (en) Method for cephasoline production
AU553682B2 (en) Cephalosporins
ITMI931954A0 (it) Metodo per produrre acido 7-amminocefalosporanico per bioconversione diretta mediante enzimi liberi recuperati per ultrafiltrazione e reimpiegati della soluzione permeata dall'ultrafiltrazione di brodocoltura harvest di cefalosporina c.
FI863678A (fi) Foerfarande foer submers odling av pseudomonas aeruginosa-bakteriestammar.
BR1100229A (pt) Microrganismo e processo para a produção de ácido glutâmico.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961230