AT400033B - Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben - Google Patents

Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Info

Publication number
AT400033B
AT400033B AT0047292A AT47292A AT400033B AT 400033 B AT400033 B AT 400033B AT 0047292 A AT0047292 A AT 0047292A AT 47292 A AT47292 A AT 47292A AT 400033 B AT400033 B AT 400033B
Authority
AT
Austria
Prior art keywords
isolating
new method
clavulanic acid
compatible salts
pharmacologically compatible
Prior art date
Application number
AT0047292A
Other languages
English (en)
Other versions
ATA47292A (de
Inventor
Franz Dr Krenmueller
Harald Dr Summer
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to AT0047292A priority Critical patent/AT400033B/de
Priority to CH670/93A priority patent/CH685054A5/de
Priority to SE9300758A priority patent/SE508043C2/sv
Priority to NO930829A priority patent/NO301372B1/no
Priority to GB9304704A priority patent/GB2264944B/en
Priority to JP5046691A priority patent/JP2817563B2/ja
Priority to DK026093A priority patent/DK26093A/da
Priority to CN93102897A priority patent/CN1045604C/zh
Priority to AU34070/93A priority patent/AU659282B2/en
Priority to IE930172A priority patent/IE70926B1/en
Priority to FR9302720A priority patent/FR2688506B1/fr
Priority to FI931032A priority patent/FI101965B/fi
Priority to DE4307422A priority patent/DE4307422B4/de
Priority to GR930100090A priority patent/GR1002329B/el
Priority to NL9300430A priority patent/NL9300430A/nl
Priority to ES09300483A priority patent/ES2058029B1/es
Priority to ITRM930147A priority patent/IT1261213B/it
Priority to TW082103491A priority patent/TW364907B/zh
Publication of ATA47292A publication Critical patent/ATA47292A/de
Application granted granted Critical
Publication of AT400033B publication Critical patent/AT400033B/de
Priority to HK42696A priority patent/HK42696A/xx
Priority to CN96108276A priority patent/CN1145906A/zh
Priority to CN96108278A priority patent/CN1150153A/zh
Priority to JP9218732A priority patent/JPH1067785A/ja
Priority to CY199597A priority patent/CY1995A/en
Priority to US09/892,179 priority patent/US20010036940A1/en
Priority to US10/071,364 priority patent/US20020072513A1/en
Priority to US10/251,948 priority patent/US20030022882A1/en
Priority to US10/437,097 priority patent/USH2158H1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
AT0047292A 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben AT400033B (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
CH670/93A CH685054A5 (de) 1992-03-10 1993-03-05 Verfahren zur Herstellung von Clavulansäuresalzen.
NO930829A NO301372B1 (no) 1992-03-10 1993-03-08 Fremgangsmåte for fremstilling av et farmasöytisk tålbart salt av klavulansyre
GB9304704A GB2264944B (en) 1992-03-10 1993-03-08 Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid
JP5046691A JP2817563B2 (ja) 1992-03-10 1993-03-08 クラブラン酸塩の製造方法
SE9300758A SE508043C2 (sv) 1992-03-10 1993-03-08 Förfarande för framställning och användning av 2-amino-2,4,4- trimetylpentansaltet av klavulansyra som mellanprodukt vid framställning av farmaceutiskt godtagbara salter av klavulansyra
GR930100090A GR1002329B (el) 1992-03-10 1993-03-09 Μεθοδος για την παραγωγη αλατων κλαβουλανικου οξεος.
AU34070/93A AU659282B2 (en) 1992-03-10 1993-03-09 Process for the production of pharmaceutically acceptable salts of clavulanic acid
IE930172A IE70926B1 (en) 1992-03-10 1993-03-09 Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid
FR9302720A FR2688506B1 (fr) 1992-03-10 1993-03-09 Procede de preparation de sels de l'acide clavulanique.
FI931032A FI101965B (fi) 1992-03-10 1993-03-09 Klavulaanihapon 2-amino-2,4,4-trimetyylipentaanisuolan käyttö klavulaa nihapon alkali- tai maa-alkalimetallisuolojen valmistuksessa
DE4307422A DE4307422B4 (de) 1992-03-10 1993-03-09 Verfahren zur Herstellung von Clavulansäuresalzen
DK026093A DK26093A (da) 1992-03-10 1993-03-09 Fremgangsmaade til fremstilling af clavulansyresalte
CN93102897A CN1045604C (zh) 1992-03-10 1993-03-09 棒酸盐的制备方法
ITRM930147A IT1261213B (it) 1992-03-10 1993-03-10 Procedimento per la preparazione di sali dell'acido clavulanico.
ES09300483A ES2058029B1 (es) 1992-03-10 1993-03-10 Proceso para la produccion de sales del acido clavulanico.
NL9300430A NL9300430A (nl) 1992-03-10 1993-03-10 Werkwijze voor het bereiden van zouten van clavulaanzuur.
TW082103491A TW364907B (en) 1992-03-10 1993-05-04 Process for the production of the potassium salt of clavulanic acid via the 2-amino-2,4,4-trimethylpentane salt thereof
HK42696A HK42696A (en) 1992-03-10 1996-03-14 Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid
CN96108278A CN1150153A (zh) 1992-03-10 1996-06-29 2-氨基-2，4，4-三甲基戊烷棒酸盐的应用
CN96108276A CN1145906A (zh) 1992-03-10 1996-06-29 药用棒酸盐的制造方法
JP9218732A JPH1067785A (ja) 1992-03-10 1997-08-13 クラブラン酸の２−アミノ−２，４，４−トリメチルペンタン塩
CY199597A CY1995A (en) 1992-03-10 1997-09-05 Use of 2-amino-2,4,4-trimethylpentane salt of clavulanic acid in producing pharmaceutically acceptable salts of clavulanic acid
US09/892,179 US20010036940A1 (en) 1992-03-10 2001-06-26 Process for the production of clavulanic acid salts
US10/071,364 US20020072513A1 (en) 1992-03-10 2002-02-08 Process for the production of clavulanic acid salts
US10/251,948 US20030022882A1 (en) 1992-03-10 2002-09-20 Process for the production of clavulanic acid salts
US10/437,097 USH2158H1 (en) 1992-03-10 2003-05-13 Process for the production of clavulanic acid salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Publications (2)

Publication Number Publication Date
ATA47292A ATA47292A (de) 1995-01-15
AT400033B true AT400033B (de) 1995-09-25

Family

ID=3491521

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0047292A AT400033B (de) 1992-03-10 1992-03-10 Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben

Country Status (21)

Country Link
US (4) US20010036940A1 (de)
JP (2) JP2817563B2 (de)
CN (3) CN1045604C (de)
AT (1) AT400033B (de)
AU (1) AU659282B2 (de)
CH (1) CH685054A5 (de)
CY (1) CY1995A (de)
DE (1) DE4307422B4 (de)
DK (1) DK26093A (de)
ES (1) ES2058029B1 (de)
FI (1) FI101965B (de)
FR (1) FR2688506B1 (de)
GB (1) GB2264944B (de)
GR (1) GR1002329B (de)
HK (1) HK42696A (de)
IE (1) IE70926B1 (de)
IT (1) IT1261213B (de)
NL (1) NL9300430A (de)
NO (1) NO301372B1 (de)
SE (1) SE508043C2 (de)
TW (1) TW364907B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
EP0658558B1 (de) 1993-11-17 2001-01-24 Biochemie Gesellschaft M.B.H. Trennung von Cephalosporinisomeren
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (de) * 1995-02-25 2001-12-19 Spurcourt Limited Clavulansäure Salz
KR100200242B1 (ko) * 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
CA2337072A1 (en) * 1998-07-16 2000-01-27 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid
DE60008508T9 (de) * 1999-04-01 2012-06-14 Dsm Ip Assets B.V. Agglomerate durch kristallisation
DK1284978T4 (da) * 2000-05-13 2009-01-05 Smithkline Beecham Plc Fremgangsmåde til oprensning af et salt af clavulansyre
WO2007030668A2 (en) * 2005-09-07 2007-03-15 Jennerex Biotherapeutics Ulc Systemic treatment of metastatic and/or systemically-disseminated cancers using gm-csf-expressing poxviruses
JP7028064B2 (ja) 2018-05-30 2022-03-02 横河電機株式会社 機器保全装置、機器保全方法、機器保全プログラム及び記録媒体
CN115768544A (zh) 2020-07-10 2023-03-07 碳清洁解决方案有限公司 用低品位热从溶剂去除二氧化碳的方法和系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens

Family Cites Families (33)

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Publication number Priority date Publication date Assignee Title
US3288800A (en) 1962-05-29 1966-11-29 Squibb & Sons Inc Schiff's bases of 6-amino-penicillanic acid and purification of 6-aminopenicillanic acid by the use thereof
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41109B1 (en) 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1543563A (en) 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1561395A (en) 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB2003863B (en) 1977-09-01 1982-03-31 Beecham Group Ltd Chemical process
EP0002312B1 (de) 1977-11-26 1982-02-03 Beecham Group Plc Clavulansäure-derivate sowie sie enthaltende pharmazeutische Zusammensetzungen
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
AU600655B2 (en) 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
GB8618888D0 (en) 1986-08-01 1986-09-10 Davy Mckee Ltd Process
DE3853962T2 (de) 1987-01-29 1996-02-08 Beecham Group Plc Verfahren zur Kristallisation von Kalium-Clavulanat.
US5679789A (en) 1987-01-29 1997-10-21 Beecham Group, P.L.C. Pharmaceutical compositions comprising potassium clavulanate and methods of using them
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
US5210296A (en) 1990-11-19 1993-05-11 E. I. Du Pont De Nemours And Company Recovery of lactate esters and lactic acid from fermentation broth
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
EP0729961B1 (de) 1995-02-25 2001-12-19 Spurcourt Limited Clavulansäure Salz
GB2298201B (en) 1995-02-25 1997-05-28 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
KR100200242B1 (ko) 1995-05-16 1999-06-15 김충환 클라불란산염의 제조 방법
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ZA975198B (en) 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
CN1238776A (zh) 1996-11-11 1999-12-15 吉斯特-布罗卡迪斯有限公司 制备棒酸盐和酯的方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE862211A (fr) * 1977-12-22 1978-06-22 Beecham Group Ltd Agents antibacteriens

Also Published As

Publication number Publication date
USH2158H1 (en) 2006-06-06
JPH0641143A (ja) 1994-02-15
NO301372B1 (no) 1997-10-20
AU659282B2 (en) 1995-05-11
GR1002329B (el) 1996-05-15
DE4307422B4 (de) 2004-11-25
SE508043C2 (sv) 1998-08-17
GR930100090A (el) 1993-11-30
ITRM930147A0 (it) 1993-03-10
JPH1067785A (ja) 1998-03-10
HK42696A (en) 1996-03-22
ATA47292A (de) 1995-01-15
SE9300758D0 (sv) 1993-03-08
US20010036940A1 (en) 2001-11-01
AU3407093A (en) 1993-09-16
FR2688506B1 (fr) 1995-06-23
GB2264944A (en) 1993-09-15
JP2817563B2 (ja) 1998-10-30
FI101965B1 (fi) 1998-09-30
DK26093D0 (da) 1993-03-09
IE930172A1 (en) 1993-09-22
NO930829L (no) 1993-09-13
FI931032A0 (fi) 1993-03-09
IT1261213B (it) 1996-05-09
NO930829D0 (no) 1993-03-08
FI101965B (fi) 1998-09-30
US20030203886A1 (en) 2003-10-30
CN1079743A (zh) 1993-12-22
CN1045604C (zh) 1999-10-13
GB9304704D0 (en) 1993-04-28
IE70926B1 (en) 1997-01-15
US20020072513A1 (en) 2002-06-13
CH685054A5 (de) 1995-03-15
CN1145906A (zh) 1997-03-26
DE4307422A1 (de) 1993-09-30
ITRM930147A1 (it) 1994-09-10
SE9300758L (sv) 1993-09-11
US20030022882A1 (en) 2003-01-30
FR2688506A1 (fr) 1993-09-17
FI931032L (fi) 1993-09-11
ES2058029A1 (es) 1994-10-16
NL9300430A (nl) 1993-10-01
DK26093A (da) 1993-09-11
TW364907B (en) 1999-07-21
CY1995A (en) 1997-09-05
CN1150153A (zh) 1997-05-21
ES2058029B1 (es) 1995-05-01
GB2264944B (en) 1995-09-06

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