DE69324163D1 - Verfahren zur herstellung von clavulansäure - Google Patents

Verfahren zur herstellung von clavulansäure

Info

Publication number
DE69324163D1
DE69324163D1 DE69324163T DE69324163T DE69324163D1 DE 69324163 D1 DE69324163 D1 DE 69324163D1 DE 69324163 T DE69324163 T DE 69324163T DE 69324163 T DE69324163 T DE 69324163T DE 69324163 D1 DE69324163 D1 DE 69324163D1
Authority
DE
Germany
Prior art keywords
clavulanic acid
producing clavulanic
producing
acid
clavulanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69324163T
Other languages
English (en)
Other versions
DE69324163T2 (de
Inventor
Keith Howard Baggaley
Neville Hubert Nicholson
Stephen William Elson
Jeffrey Edwards
Alison Jane Earl
William Henry Holms
David Michael Mousdale
Jack Edward Baldwin
Christopher Schofield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929225151A external-priority patent/GB9225151D0/en
Priority claimed from GB929225152A external-priority patent/GB9225152D0/en
Priority claimed from GB939304761A external-priority patent/GB9304761D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE69324163D1 publication Critical patent/DE69324163D1/de
Publication of DE69324163T2 publication Critical patent/DE69324163T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69324163T 1992-12-02 1993-11-26 Verfahren zur herstellung von clavulansäure Expired - Lifetime DE69324163T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929225151A GB9225151D0 (en) 1992-12-02 1992-12-02 Novel compounds
GB929225152A GB9225152D0 (en) 1992-12-02 1992-12-02 Novel compounds
GB939304761A GB9304761D0 (en) 1993-03-09 1993-03-09 Novel compounds
PCT/GB1993/002442 WO1994012654A1 (en) 1992-12-02 1993-11-26 Process for preparing clavulanic acid

Publications (2)

Publication Number Publication Date
DE69324163D1 true DE69324163D1 (de) 1999-04-29
DE69324163T2 DE69324163T2 (de) 1999-09-23

Family

ID=27266492

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69324163T Expired - Lifetime DE69324163T2 (de) 1992-12-02 1993-11-26 Verfahren zur herstellung von clavulansäure

Country Status (7)

Country Link
US (1) US5869299A (de)
EP (1) EP0673432B1 (de)
JP (3) JP3558295B2 (de)
AU (1) AU5570194A (de)
DE (1) DE69324163T2 (de)
ES (1) ES2130392T3 (de)
WO (1) WO1994012654A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9424950D0 (en) * 1994-12-10 1995-02-08 Smithkline Beecham Plc Novel process
GB9815666D0 (en) * 1998-07-17 1998-09-16 Smithkline Beecham Plc Novel compounds
EP1026236A1 (de) * 1999-02-04 2000-08-09 Dsm N.V. Auxotrophe Stämme zur Sekundärstoffwechselprodukt-Biosynthese
WO2001019959A1 (en) * 1999-09-16 2001-03-22 The Johns Hopkins University Improvement of clavulanic acid production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8521516D0 (en) * 1985-08-29 1985-10-02 Beecham Group Plc Compounds
GB8813055D0 (en) * 1988-06-02 1988-07-06 Beecham Group Plc Novel substance
US5118617A (en) * 1989-05-19 1992-06-02 Applied Research Systems Ars Holding N.V. Saf polypeptide, gene coding therefor, saf promoter and expression methods for expressing foreign dna sequences in streptomyces

Also Published As

Publication number Publication date
DE69324163T2 (de) 1999-09-23
JP2004002420A (ja) 2004-01-08
JP2004166714A (ja) 2004-06-17
JP3507067B2 (ja) 2004-03-15
AU5570194A (en) 1994-06-22
EP0673432A1 (de) 1995-09-27
JP3558295B2 (ja) 2004-08-25
WO1994012654A1 (en) 1994-06-09
JPH08504579A (ja) 1996-05-21
US5869299A (en) 1999-02-09
EP0673432B1 (de) 1999-03-24
ES2130392T3 (es) 1999-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition