ES2130392T3 - Procedimiento para la preparacion de acido clavulanico. - Google Patents
Procedimiento para la preparacion de acido clavulanico.Info
- Publication number
- ES2130392T3 ES2130392T3 ES94900928T ES94900928T ES2130392T3 ES 2130392 T3 ES2130392 T3 ES 2130392T3 ES 94900928 T ES94900928 T ES 94900928T ES 94900928 T ES94900928 T ES 94900928T ES 2130392 T3 ES2130392 T3 ES 2130392T3
- Authority
- ES
- Spain
- Prior art keywords
- clavulanic acid
- procedure
- preparation
- compounds
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
UN PROCESO PARA PREPARAR ACIDO CLAVULANICO Y OTROS DERIVADOS DEL CLAVANO DESDE CUALQUIERA DE LAS S-ARGININA, COMPUESTOS DE FORMULA (I), DONDE R1 ES (A) O (B), DONDE R2 =H O C1-6ALQUILO; COMPUESTOS DE LA FORMULA (II), DONDE R1 ES (C) O (D), DONDE R2=H O C1-6ALQUILO O COMPUESTOS DE LA FORMULA (III), DONDE R ES H O OH Y DONDE R1 ES (E) 0 (F), DONDE R2 = H O C1-6ALQUILO, UTILIZANDO UN SISTEMA DE ENZIMA DE STREPTOMYCES, PREFERIBLEMENTE 3S.CLAVULIGERUS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929225152A GB9225152D0 (en) | 1992-12-02 | 1992-12-02 | Novel compounds |
GB929225151A GB9225151D0 (en) | 1992-12-02 | 1992-12-02 | Novel compounds |
GB939304761A GB9304761D0 (en) | 1993-03-09 | 1993-03-09 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2130392T3 true ES2130392T3 (es) | 1999-07-01 |
Family
ID=27266492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94900928T Expired - Lifetime ES2130392T3 (es) | 1992-12-02 | 1993-11-26 | Procedimiento para la preparacion de acido clavulanico. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5869299A (es) |
EP (1) | EP0673432B1 (es) |
JP (3) | JP3558295B2 (es) |
AU (1) | AU5570194A (es) |
DE (1) | DE69324163T2 (es) |
ES (1) | ES2130392T3 (es) |
WO (1) | WO1994012654A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9424950D0 (en) * | 1994-12-10 | 1995-02-08 | Smithkline Beecham Plc | Novel process |
GB9815666D0 (en) | 1998-07-17 | 1998-09-16 | Smithkline Beecham Plc | Novel compounds |
EP1026236A1 (en) * | 1999-02-04 | 2000-08-09 | Dsm N.V. | Auxotrophic strains for secondary metabolite biosynthesis |
EP1218486A4 (en) * | 1999-09-16 | 2002-11-04 | Univ Johns Hopkins | IMPROVEMENT OF CLAVULIC ACID PRODUCTION |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8521516D0 (en) * | 1985-08-29 | 1985-10-02 | Beecham Group Plc | Compounds |
GB8813055D0 (en) * | 1988-06-02 | 1988-07-06 | Beecham Group Plc | Novel substance |
US5118617A (en) * | 1989-05-19 | 1992-06-02 | Applied Research Systems Ars Holding N.V. | Saf polypeptide, gene coding therefor, saf promoter and expression methods for expressing foreign dna sequences in streptomyces |
-
1993
- 1993-11-26 WO PCT/GB1993/002442 patent/WO1994012654A1/en active IP Right Grant
- 1993-11-26 DE DE69324163T patent/DE69324163T2/de not_active Expired - Lifetime
- 1993-11-26 EP EP94900928A patent/EP0673432B1/en not_active Expired - Lifetime
- 1993-11-26 US US08/446,806 patent/US5869299A/en not_active Expired - Lifetime
- 1993-11-26 JP JP51292594A patent/JP3558295B2/ja not_active Expired - Fee Related
- 1993-11-26 AU AU55701/94A patent/AU5570194A/en not_active Abandoned
- 1993-11-26 ES ES94900928T patent/ES2130392T3/es not_active Expired - Lifetime
-
2003
- 2003-05-19 JP JP2003140429A patent/JP3507067B2/ja not_active Expired - Fee Related
-
2004
- 2004-03-05 JP JP2004062209A patent/JP2004166714A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2004166714A (ja) | 2004-06-17 |
EP0673432B1 (en) | 1999-03-24 |
AU5570194A (en) | 1994-06-22 |
US5869299A (en) | 1999-02-09 |
JP2004002420A (ja) | 2004-01-08 |
DE69324163T2 (de) | 1999-09-23 |
DE69324163D1 (de) | 1999-04-29 |
JP3558295B2 (ja) | 2004-08-25 |
WO1994012654A1 (en) | 1994-06-09 |
JP3507067B2 (ja) | 2004-03-15 |
EP0673432A1 (en) | 1995-09-27 |
JPH08504579A (ja) | 1996-05-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU643489B2 (en) | Antibacterial agents - II | |
SE8002292L (sv) | 4-amino-3-kinolinkarboxylsyror och estrar som antisekretoriska anti-ulcerosa foreningar | |
DE3466538D1 (de) | Hexadecanoic acid and hexadecadienoic-acid derivatives | |
NO180719C (no) | Analogifremgangsmåte for fremstilling av terapeutisk aktive A-nor-steroid-3-carboxylsyrederivater | |
FI931855A (fi) | Farmaceutisk sammansaettning som innehaoller kinolin- och kinazolinderivat samt nya foereningar daerfoer | |
FI905748A0 (fi) | Foerfarande foer framstaellning av 4-o -fosfater av dopamin och dopaminderivat. | |
GR1002573B (el) | Μικροβιακη μεθοδος παρασκευης μεβινολινης. | |
ES2130392T3 (es) | Procedimiento para la preparacion de acido clavulanico. | |
AU6466990A (en) | New intermediates of pyridone, process and intermediates of preparation,their application as medicaments and compositions containing them | |
JPS55111463A (en) | Beta-lactam compound and its preparation | |
EP0453574A4 (en) | Cephalosporin derivative | |
ES2001410A6 (es) | Un procedimiento para la preparacion de nuevos derivados de clavam, utiles para la preparacion de acido clavulanico, e intermedios de los mismos. | |
PT92270A (pt) | Processo para a preparacao de solvatos de um antibiotico beta-lactamico | |
FR2581641B1 (fr) | Procede de preparation d'acides 6-alkoxy(inferieur)-1-naphtoiques et des esters correspondants et utilisation de ce procede pour la preparation d'acides 6-alkoxy(inferieur)-5-halo-1-naphtoiques et des esters correspondants | |
ES509782A0 (es) | Un procedimiento para la preparacion de nuevos bis-esteres de metanodiol y etanodiol. | |
HU910108D0 (en) | Process for the production of macrolide compounds | |
ES2060854T3 (es) | Procedimiento para la preparacion de acido 2-mercapto-4-metil-1,3-tiazol-5-il-acetico y sus esteres. | |
PT82401B (pt) | Processo para a preparacao de derivados do acido 6-(1-acil-1-hidroximetil)penicilanico | |
PT90509A (pt) | Processo para a preparacao de derivados de cefalosporina e de composicoes farmaceuticas que os contem | |
AU7500187A (en) | Substituted isoquinoline derivatives and anti-ulcer agents | |
ES2075154T3 (es) | Un inhibidor de fosfolipasa a2, metodo para producirlo y formulaciones farmaceuticas o veterinarias que comprenden dicho inhibidor. | |
CA2193310A1 (fr) | Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui les contiennent | |
ES2194871T3 (es) | Deshidrogenasa del acido clavulanico, preparacion y uso para la produccion de acido clavulanico. | |
DE2966347D1 (en) | Clavulanic acid derivatives and process for their preparation | |
JPS5452068A (en) | 2-azetidinone derivative and its preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 673432 Country of ref document: ES |