ES2075154T3 - Un inhibidor de fosfolipasa a2, metodo para producirlo y formulaciones farmaceuticas o veterinarias que comprenden dicho inhibidor. - Google Patents

Un inhibidor de fosfolipasa a2, metodo para producirlo y formulaciones farmaceuticas o veterinarias que comprenden dicho inhibidor.

Info

Publication number
ES2075154T3
ES2075154T3 ES90304552T ES90304552T ES2075154T3 ES 2075154 T3 ES2075154 T3 ES 2075154T3 ES 90304552 T ES90304552 T ES 90304552T ES 90304552 T ES90304552 T ES 90304552T ES 2075154 T3 ES2075154 T3 ES 2075154T3
Authority
ES
Spain
Prior art keywords
inhibitor
compound
producing
pharmaceutical
phosfolipase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90304552T
Other languages
English (en)
Inventor
Tadasi Yoshida
Hitoshi Arita
Jun Ichi Shoji
Keizo Inoue
Shigeru Matsutani
Yoshimi Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of ES2075154T3 publication Critical patent/ES2075154T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Botany (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

COMPUESTO DE LA FORMULA: EN DONDE LA LINEA DE LAS ONDAS SIGNIFICA UN ENLACE (ALFA) O (BETA), CUYO COMPUESTO RESULTA DE GRAN UTILIDAD COMO INIHIBIDOR DE FOSFOLIPASA A2. TAMBIEN SE REVELA EL PROCESO PARA LA PRODUCCION DEL COMPUESTO, COMPOSICION FARMACEUTICA QUE LO CONTIENE Y CULTIVO DE CELULAS DE UN MICROORGANISMO "THIELAVIA TERRICOLA" RF-143 QUE PRODUCE EL COMPUESTO.
ES90304552T 1989-04-28 1990-04-26 Un inhibidor de fosfolipasa a2, metodo para producirlo y formulaciones farmaceuticas o veterinarias que comprenden dicho inhibidor. Expired - Lifetime ES2075154T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1109939A JP2842613B2 (ja) 1989-04-28 1989-04-28 フォスフォリパーゼａ▲下２▼阻害物質

Publications (1)

Publication Number Publication Date
ES2075154T3 true ES2075154T3 (es) 1995-10-01

Family

ID=14522941

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90304552T Expired - Lifetime ES2075154T3 (es) 1989-04-28 1990-04-26 Un inhibidor de fosfolipasa a2, metodo para producirlo y formulaciones farmaceuticas o veterinarias que comprenden dicho inhibidor.

Country Status (7)

Country Link
US (1) US5011952A (es)
EP (1) EP0395418B1 (es)
JP (1) JP2842613B2 (es)
AT (1) ATE123028T1 (es)
DE (1) DE69019591T2 (es)
DK (1) DK0395418T3 (es)
ES (1) ES2075154T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2090434A1 (en) * 1991-07-03 1993-01-04 Mitsuaki Ohtani Phospholipase a2 inhibitor
CA2100640A1 (en) * 1992-07-23 1994-01-24 Shigeru Matsutani Substitute benzoate derivatives
GB9226724D0 (en) * 1992-12-22 1993-02-17 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
JP2842613B2 (ja) 1999-01-06
DE69019591T2 (de) 1996-01-25
EP0395418B1 (en) 1995-05-24
EP0395418A1 (en) 1990-10-31
DK0395418T3 (da) 1995-08-07
US5011952A (en) 1991-04-30
ATE123028T1 (de) 1995-06-15
JPH02286088A (ja) 1990-11-26
DE69019591D1 (de) 1995-06-29

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