ES2073529T3 - Inhibidor de fosfolipasa a2, microorganismos que producen este inhibidor y procedimiento para su produccion. - Google Patents
Inhibidor de fosfolipasa a2, microorganismos que producen este inhibidor y procedimiento para su produccion.Info
- Publication number
- ES2073529T3 ES2073529T3 ES90306872T ES90306872T ES2073529T3 ES 2073529 T3 ES2073529 T3 ES 2073529T3 ES 90306872 T ES90306872 T ES 90306872T ES 90306872 T ES90306872 T ES 90306872T ES 2073529 T3 ES2073529 T3 ES 2073529T3
- Authority
- ES
- Spain
- Prior art keywords
- inhibitor
- phospholipase
- production
- coor
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
SE PRESENTA UN COMPUESTO DE LA FORMULA (I) EN EL CUAL R1, R2 Y R3 SON -COOR4, -COOR5, Y -COOR6, RESPECTIVAMENTE; R4, R5 Y R6 SON CADA UNA HIDROGENO, ALQUIL INFERIOR, O METAL ALCALI; W ES HIDROXIL; X, Y Y Z SON CADA UNA HIDROGENO O HIDROXIL; LA LINEA PUNTEADA INDICA LA PRESENCIA O AUSENCIA DE UN ENLACE SIMPLE; Y EN LA QUE W/R3, X/R1, Y / O Z/R3 PUEDEN SER COMBINADAS JUNTAS, PARA FORMAR UNA LACTONA. DICHO COMPUESTO ES UTIL COMO UN INHIBIDOR DE LA FOSFOLIPASA A2. TAMBIEN SE PRESENTA UN PROCESO PARA LA PREPARACION DEL COMPOUESTO DE LA FORMULA (I), UN CULTIVO DE UN MICROORGANISMO "CIRCINOTRICHUM FALCATISPORUM" RF-641 PRODUCTOR DE DICHO COMPUESTO Y LAS COMPOSICIONES FARMACEUTICAS QUE LO CONTIENEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17039689 | 1989-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2073529T3 true ES2073529T3 (es) | 1995-08-16 |
Family
ID=15904154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90306872T Expired - Lifetime ES2073529T3 (es) | 1989-06-30 | 1990-06-22 | Inhibidor de fosfolipasa a2, microorganismos que producen este inhibidor y procedimiento para su produccion. |
Country Status (8)
Country | Link |
---|---|
US (2) | US5099034A (es) |
EP (1) | EP0405864B1 (es) |
JP (1) | JPH03108490A (es) |
KR (1) | KR910001037A (es) |
AT (1) | ATE121091T1 (es) |
DE (1) | DE69018529T2 (es) |
DK (1) | DK0405864T3 (es) |
ES (1) | ES2073529T3 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5096923A (en) * | 1990-03-21 | 1992-03-17 | Merck & Co., Inc. | Novel squalene synthetase inhibitors |
US5132320A (en) * | 1990-03-21 | 1992-07-21 | Merck & Co., Inc. | Squalene synthetase inhibitors |
US5278064A (en) * | 1991-08-01 | 1994-01-11 | Eli Lilly And Company | Amycolatopsis mediterranei strains useful to prepare A87689 compounds |
US5350579A (en) * | 1991-08-01 | 1994-09-27 | Eli Lilly And Company | A87689 compounds employed as a phospholipase A2 (PLA2) inhibitor to treat inflammatory diseases |
US5254727A (en) * | 1992-10-19 | 1993-10-19 | Merck & Co., Inc. | Acyclic tricarboxylic acid compounds |
GB9226724D0 (en) * | 1992-12-22 | 1993-02-17 | Xenova Ltd | Pharmaceutical compounds |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
WO2000063703A1 (en) * | 1999-04-16 | 2000-10-26 | Schering Corporation | Use of azetidinone compounds |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
DE60221798T2 (de) * | 2001-01-26 | 2008-06-05 | Schering Corp. | Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen |
RU2756946C2 (ru) * | 2001-01-26 | 2021-10-07 | Мерк Шарп И Доум Корп. | Применение замещенных азетидинонов для лечения ситостеролемии |
PT1353694E (pt) * | 2001-01-26 | 2008-03-12 | Schering Corp | Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares |
ES2286233T3 (es) * | 2001-01-26 | 2007-12-01 | Schering Corporation | Combinaciones de inhibidor(es) de la absorcion de esteroles con agente(s) cardiovascular(es) para el tratamiento de afecciones vasculares. |
US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
MXPA03006727A (es) * | 2001-01-26 | 2003-10-24 | Schering Corp | Combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y tratamiento para indicaciones vasculares. |
DK1353696T3 (da) * | 2001-01-26 | 2007-04-10 | Schering Corp | Kombinationer af peroxisomproliferatoraktiveret receptor (PPAR)-aktivator(er) og sterolabsorptionsinhibitor(er) og behandlinger til vaskulære indikationer |
CA2447884A1 (en) * | 2001-05-25 | 2002-12-05 | Schering Corporation | Use of azetidinone substituted derivatives in the treatment of alzheimer's disease |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
PT1427409E (pt) * | 2001-09-21 | 2008-11-27 | Schering Corp | Métodos para tratar ou para impedir a inflamação vascular utilizando inibidor(es) de absorção de esteróis |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
EP1429756B1 (en) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
US20040018533A1 (en) * | 2002-06-04 | 2004-01-29 | Adam Gail Isabel Reid | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
US20050014158A1 (en) * | 2002-06-27 | 2005-01-20 | Adam Gail Isabel Reid | Therapeutic methods for reducing fat deposition and treating associated conditions |
WO2004043456A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
CA2517573C (en) | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
ES2318274T3 (es) | 2003-03-07 | 2009-05-01 | Schering Corporation | Compuestos de azetidinona sustituida, formulaciones y uso de los mismos para el tratamiento de hipercolesterolemia. |
EP1601668B1 (en) * | 2003-03-07 | 2008-08-27 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
CA2544309A1 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
JP4606209B2 (ja) * | 2005-03-10 | 2011-01-05 | ダイセル化学工業株式会社 | ラクトン化合物及びラクトン化合物の製造法 |
US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
US7897800B2 (en) * | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
ES2328214B1 (es) | 2008-05-06 | 2010-07-23 | Consejo Superior De Investigaciones Cientificas | Procedimiento de obtencion de las cinatrinas c3 y c1. |
CA2750636C (en) | 2009-01-23 | 2017-07-25 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
JP2013249293A (ja) * | 2012-06-04 | 2013-12-12 | Kao Corp | リパーゼ活性阻害剤、抗真菌剤、及びフケ抑制剤 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3943165A (en) * | 1972-07-14 | 1976-03-09 | Lever Brothers Company | Esters of carboxymethyloxysuccinic acid and derivatives thereof |
US4145437A (en) * | 1975-08-21 | 1979-03-20 | Imperial Chemical Industries Limited | Hydroxy acids |
GB8401149D0 (en) * | 1984-01-17 | 1984-02-22 | Fujisawa Pharmaceutical Co | Furanone derivatives |
IT1213330B (it) * | 1986-08-28 | 1989-12-20 | Rol Spa | Tensioattivi derivati da idrossiacidi bi- o tri-carbossilici. |
DE3830068A1 (de) * | 1988-09-03 | 1990-04-05 | Hoechst Ag | Amidoamin-salze von alkenylbernsteinsaeurederivaten, verfahren zu deren herstellung und deren verwendung als korrosionsinhibitoren |
-
1990
- 1990-06-06 JP JP2148007A patent/JPH03108490A/ja active Pending
- 1990-06-22 AT AT90306872T patent/ATE121091T1/de active
- 1990-06-22 EP EP90306872A patent/EP0405864B1/en not_active Expired - Lifetime
- 1990-06-22 ES ES90306872T patent/ES2073529T3/es not_active Expired - Lifetime
- 1990-06-22 DK DK90306872.4T patent/DK0405864T3/da active
- 1990-06-22 DE DE69018529T patent/DE69018529T2/de not_active Expired - Fee Related
- 1990-06-27 US US07/544,673 patent/US5099034A/en not_active Expired - Fee Related
- 1990-06-30 KR KR1019900009839A patent/KR910001037A/ko not_active Application Discontinuation
- 1990-11-26 US US07/617,882 patent/US5120647A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5120647A (en) | 1992-06-09 |
DE69018529D1 (de) | 1995-05-18 |
US5099034A (en) | 1992-03-24 |
JPH03108490A (ja) | 1991-05-08 |
DE69018529T2 (de) | 1996-03-21 |
KR910001037A (ko) | 1991-01-30 |
EP0405864A3 (en) | 1992-01-08 |
EP0405864B1 (en) | 1995-04-12 |
ATE121091T1 (de) | 1995-04-15 |
DK0405864T3 (da) | 1995-07-03 |
EP0405864A2 (en) | 1991-01-02 |
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